The relaxing effect of α-defensin 1 on the adrenergic responses of rat bladder

Korean Journal of Physiology and Pharmacology

Volumn 15, Issue 3, 2011, Pages 143-147

  Lee, Shin Young ^a   Kim, Don Kyu ^a   Kim, Kyung Do ^a   Myung, Soon Chul ^a   Lee, Moo Yeol ^a  

^a Chung Ang University   (South Korea)

Author keywords

defensin; Adrenergic system; Detrusor smooth muscle; NF B

Indexed keywords

4 (1 AMINOETHYL) N (4 PYRIDYL)CYCLOHEXANECARBOXAMIDE; ALPHA DEFENSIN; ALPHA DEFENSIN 1; BETHANECHOL; CALPHOSTIN C; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; PHENYLEPHRINE; PHORBOL DIBUTYRATE; PYRROLIDINE DITHIOCARBAMATE; SALAZOSULFAPYRIDINE; UNCLASSIFIED DRUG;

ADRENERGIC SYSTEM; ANIMAL TISSUE; ARTICLE; BLADDER; DETRUSOR MUSCLE; DRUG EFFECT; DRUG MECHANISM; MUSCLE CONTRACTION; MUSCLE RELAXATION; NONHUMAN; RAT; SIGNAL TRANSDUCTION;

EID: 79960650115     PISSN: 12264512     EISSN: None     Source Type: Journal    
DOI: 10.4196/kjpp.2011.15.3.143     Document Type: Article

References (23)

1. Ganz T. Defensins: antimicrobial peptides of innate immunity. Nat Rev Immunol. 2003;3:710-720. (Pubitemid 41070812)
2. Selsted ME, Ouellette AJ. Mammalian defensins in the antimicrobial immune response. Nat Immunol. 2005;6:551-557. (Pubitemid 41710724)
3. Nassar T, Akkawi S, Bar-Shavit R, Haj-Yehia A, Bdeir K, Al-Mehdi AB, Tarshis M, Higazi AA. Human alpha-defensin regulates smooth muscle cell contraction: a role for low-density lipoprotein receptor-related protein/alpha 2-macroglobulin receptor. Blood. 2002;100:4026-4032. (Pubitemid 35396869)
4. Kougias P, Chai H, Lin PH, Yao Q, Lumsden AB, Chen C. Neutrophil antimicrobial peptide alpha-defensin causes endothelial dysfunction in porcine coronary arteries. J Vasc Surg. 2006;43:357-363. (Pubitemid 43221934)
5. Durlu-Kandilci NT, Brading AF. Involvement of Rho kinase and protein kinase C in carbachol-induced calcium sensitization in beta-escin skinned rat and guinea-pig bladders. Br J Pharmacol. 2006;148:376-384. (Pubitemid 43801184)
6. Meyer-Siegler KL, Iczkowski KA, Vera PL. Macrophage migration inhibitory factor is increased in the urine of patients with urinary tract infection: macrophage migration inhibitory factor-protein complexes in human urine. J Urol. 2006;175:1523-1528.
7. Chang S, Hypolite JA, Mohanan S, Zderic SA, Wein AJ, Chacko S. Alteration of the PKC-mediated signaling pathway for smooth muscle contraction in obstruction-induced hypertrophy of the urinary bladder. Lab Invest. 2009;89:823-832.
8. Kim JK, Han WH, Lee MY, Myung SC, Kim SC, Kim MK. Testosterone relaxes rabbit seminal vesicle by calcium channel inhibition. Korean J Physiol Pharmacol. 2008;12:73-77. (Pubitemid 351736662)
9. Raj PA, Dentino AR. Current status of defensins and their role in innate and adaptive immunity. FEMS Microbiol Lett. 2002;206:9-18. (Pubitemid 34084931)
10. Selsted ME, Ouellette AJ. Mammalian defensins in the antimicrobial immune response. Nat Immunol. 2005;6:551-557. (Pubitemid 41710724)
11. Lehrer RI. Multispecific myeloid defensins. Curr Opin Hematol. 2007;14:16-21. (Pubitemid 44885607)
12. Ganz T. Extracellular release of antimicrobial defensins by human polymorphonuclear leukocytes. Infect Immun. 1987;55:568-571. (Pubitemid 17021942)
13. Harwig SS, Ganz T, Lehrer RI. Neutrophil defensins: purification, characterization, and antimicrobial testing. Methods Enzymol. 1994;236:160-172. (Pubitemid 24283612)
14. Weichhart T, Haidinger M, Hörl WH, Säemann MD. Current concepts of molecular defence mechanisms operative during urinary tract infection. Eur J Clin Invest. 2008;38 Suppl 2:29-38.
15. Kougias P, Chai H, Lin PH, Yao Q, Lumsden AB, Chen C. Neutrophil antimicrobial peptide alpha-defensin causes endothelial dysfunction in porcine coronary arteries. J Vasc Surg. 2006;43:357-363. (Pubitemid 43221934)
16. Moore KH, Simons A, Mukerjee C, Lynch W. The relative incidence of detrusor instability and bacterial cystitis detected on the urodynamic-test day. BJU Int. 2000;85:786-792. (Pubitemid 30242778)
17. Sibley GN. A comparison of spontaneous and nerve-mediated activity in bladder muscle from man, pig and rabbit. J Physiol. 1984;354:431-443. (Pubitemid 14066377)
18. Stein PC, Pham H, Ito T, Parsons CL. Bladder injury model induced in rats by exposure to protamine sulfate followed by bacterial endotoxin. J Urol. 1996;155:1133-1138. (Pubitemid 26052730)
19. Meyer-Siegler KL, Ordorica RC, Vera PL. Macrophage migration inhibitory factor is upregulated in an endotoxin-induced model of bladder inflammation in rats. J Interferon Cytokine Res. 2004;24:55-63. (Pubitemid 38147267)
20. Taylor JA 3rd, Kuchel GA. Detrusor underactivity: clinical features and pathogenesis of an underdiagnosed geriatric condition. J Am Geriatr Soc. 2006;54:1920-1932. (Pubitemid 44915838)
21. Taylor JA, Zhu Q, Irwin B, Maghaydah Y, Tsimikas J, Pilbeam C, Leng L, Bucala R, Kuchel GA. Null mutation in macrophage migration inhibitory factor prevents muscle cell loss and fibrosis in partial bladder outlet obstruction. Am J Physiol Renal Physiol. 2006;291:F1343-1353.
22. Wang XC, Saban R, Kaysen JH, Saban MR, Allen PL, Benes EN, Hammond TG. Nuclear factor kappa B mediates lipopolysaccharide-induced inflammation in the urinary bladder. J Urol. 2000;163:993-998. (Pubitemid 30091676)
23. 2+ channels and its reversal by NF-kappaB inhibitors in Crohn's colitis model. Am J Physiol Gastrointest Liver Physiol. 2003;285:G483-493.