Deposition and cellular interaction of cancer-inducing particles in the human respiratory tract: Theoretical approaches and experimental data

Thoracic Cancer

Volumn 1, Issue 4, 2010, Pages 141-152

  Sturm, Robert ^a  

^a UNIVERSITY OF SALZBURG   (Austria)

Author keywords

Carcinogenicity; Lung tumor; Particle clearance; Particle deposition; Particle lung interaction

Indexed keywords

ASBESTOS FIBER; CARCINOGEN; NANOPARTICLE; REACTIVE NITROGEN SPECIES; REACTIVE OXYGEN METABOLITE;

AIRWAY; CARCINOGENESIS; CARCINOGENICITY; CELL INTERACTION; CELL PROLIFERATION; GENOTOXICITY; GEOMETRY; HUMAN; LUNG DISEASE; LUNG MODEL; PARTICLE SIZE; PARTICULATE MATTER; PRIORITY JOURNAL; RESPIRATORY SYSTEM; REVIEW; THEORETICAL MODEL;

EID: 79960646494     PISSN: 17597706     EISSN: 17597714     Source Type: Journal    
DOI: 10.1111/j.1759-7714.2010.00027.x     Document Type: Review

References (71)

1. Knaapen M, Borm PJA, Albrecht C, Schins RPF. Inhaled particles and lung cancer. Part A: mechanisms. Int J Cancer 2004; 109: 799-809.
2. Abbey DE, Nishino N, Mc Donnell WF etal. Long-term inhalable particles and other air pollutants related to mortality in nonsmokers. Am J Respir Crit Care Med 1999; 159: 373-82.
3. Pope CA, Burnett RT, Thun MJ etal. Lung cancer, cardiopulmonary mortality, and long-term exposure to fine particulate air pollution. JAMA 2002; 287: 1132-41.
4. Schins RPF. Mechanisms of genotoxicity of particles and fibres. Inhal Toxicol 2002; 14: 57-78.
5. International Commission on Radiological Protection (ICRP). Human Respiratory Tract Model for Radiological Protection, Publication 66. Pergamon Press, Oxford 1994.
6. Salvi S, Holgate ST. Mechanisms of particulate matter toxicity. Clin Exp Allergy 1999; 29: 1187-94.
7. Donaldson K, Brown D, Clouter A etal. The pulmonary toxicology of ultrafine particles. J Aerosol Med 2002; 15: 213-20.
8. Oberdörster G. Pulomonary effects of inhaled ultrafine particles. Int Arch Occup Environ Health 2001; 74: 1-8.
9. Nikula KJ, Snipes MB, Barr EB, Griffith WC, Henderson RF, Mauderly JL. Comparative pulmonary toxicicties and carcinogenicities of chronically inhaled diesel exhaust. Fundam Appl Toxicol 1995; 37: 37-53.
10. Malakoff D. Nanotechnology research. Congress wants studies of nanotech's "dark side". Science 2003; 301: 27.
11. Borm PJA, Kreyling W. Toxicological hazards of inhaled nanoparticles - potential implications for drug delivery. J Nanosci Nanotech 2004; 4: 521-31.
12. Unfried K, Schürkes C, Abel J. Distinct spectrum of mutations induced by crocidolite asbestos: clue for 8-hydroxydeoguanosine dependent mutagenesis in vivo. Cancer Res 2002; 62: 99-104.
13. Xu A, Zhou H, Yu DZ, Hei TK. Mechanisms of the genotoxicity of crocidolite asbestos in mammalian cells: implication from mutation patterns induced by reactive oxygen species. Env Health Persp 2002; 110: 1003-8.
14. Fubini B, Hubbard A. Reactive oxygen species (ROS) and reactive nitrogen species (RNS) generation by silica in inflammation and fibrosis. Free Radic Biol Med 2003; 34: 1507-16.
15. Deshpande A, Narayanan PK, Lehnert BE. Silica-induced generation of extracellular factor(s) increases reactive oxygen species in human bronchial epithelial cells. Toxicol Sci 2002; 67: 275-83.
16. Dellinger B, Pryor WA, Cueto R, Squadrito GL, Hedge V, Deutsch WA. Role of free radiclas in the toxicity of airborne fine particulate matter. Chem Res Toxicol 2001; 14: 1371-7.
17. Voelkel K, Krug HF, Diabate S. Formation of reactive oxygen species in rat epithelial cells upon stimulation with fly ash. J Biosci 2003; 28: 51-5.
18. Carter JD, Driscoll KE. The role of inflammation, oxidative stress, and proliferation in silica-induced lung disease: a species comparison. J Env Pathol Toxicol Oncol 2001; 20: 33-43.
19. Horsfield K, Dart G, Olson DE, Filley GF, Cumming G. Models of the human bronchial tree. J Appl Physiol 1971; 31: 207-17.
20. Weibel ER. Morphometry of the Human Lung. Springer, Berlin 1963.
21. Yeh HC, Schum GM. Models of the human lung airways and their aplication to inhaled particle deposition. Bull Math Biol 1980; 42: 461-80.
22. Taulbee DB, Yu CP. A theory of aerosol deposition in the human respiratory tract. J Appl Physiol 1975; 38: 77-85.
23. Soong TT, Nicolaides P, Yu CP, Soong SC. A statistical description of the human tracheobronchial tree geometry. Respir Physiol 1979; 37: 161-72.
24. 220Rn. Health Phys 1986; 50: 345-67.
25. Yu CP, Nicolaides P, Soong TT. Effect of random airway sizes on aerosol deposition. Am Ind Hyg Assoc J 1979; 40: 999-1005.
26. Koblinger L, Hofmann W. Analysis of human lung morphometric data for stochastic aerosol deposition calculations. Phys Med Biol 1985; 30: 541-56.
27. Koblinger L, Hofmann W. Monte Carlo modeling of aerosol deposition in human lungs. Part I: simulation of particle transport in a stochastic lung structure. J Aerosol Sci 1990; 21: 661-74.
28. Hofmann W, Koblinger L. Monte Carlo modeling of aerosol deposition in human lungs. Part II: deposition fractions and their sensitivity to parameter variations. J Aerosol Sci 1990; 21: 675-88.
29. Hofmann W, Koblinger L. Monte Carlo modeling of aerosol deposition in human lungs. Part III: comparison with experimental data. J Aerosol Sci 1992; 23: 51-63.
30. Heistracher T, Hofmann W. Flow and deposition patterns in successive airway bifurcations. Ann Occup Hyg 1997; 41: 537-42.
31. Kim CS, Fisher DM. Deposition of aerosol particles in successively bifurcating airway models. Aerosol Sci Technol 1999; 31: 198-220.
32. Kim CS, Iglesias AJ. Deposition of inhaled particles in bifurcating airway models: I. Inspiratory deposition. J Aerosol Med 1989; 2: 1-14.
33. Kim CS, Garcia L. Particle deposition in cyclic bifurcating tube flow. Aerosol Sci Technol 1991; 14: 302-15.
34. Hofmann W, Asgharian B, Winkler-Heil R. Modeling intersubject variability of particle deposition in human lungs. J Aerosol Sci 2002; 33: 219-35.
35. Baláshazy I, Hofmann W. Deposition of aerosols in asymmetric airway bifurcations. J Aerosol Sci 1995; 26: 273-92.
36. Heistracher T, Hofmann W. Physiologically realistic models of bronchial airway bifurcations. J Aerosol Sci 1995; 26: 497-509.
37. Baláshazy I, Heistracher T, Hofmann W. Deposition enhancement factors for inhaled radon decay products in bronchial airway bifurcations. J Aerosol Sci 1997; 28: S597-8.
38. Lippmann M, Albert RE. The effect of particle size on the regional deposition of inhaled aerosols in the human respiratory tract. Am Ind Hyg Assoc J 1969; 30: 257-75.
39. Lippmann M, Yeates DB, Albert RE. Deposition, retention, and clearance of inhaled particles. Br J Ind Med 1980; 37: 337-62.
40. Brain JD, Proctor DF, Reid LM. Respiratory Defense Mechanisms. Marcel Dekker Inc., New York 1977.
41. Gehr P, Heyder J. Particle-Lung Interactions. Marcel Dekker Inc., New York, Basel 2000.
42. Geiser M, Cruz-Orive L, Im Hof V, Gehr P. Assessment of particle retention in the conducting airways of hamster lungs. J Aerosol Med 1990; 3: 131-45.
43. Lee PS, Gerrity TR, Hass FJ, Lourenco RV. A model for tracheobronchial clearance of inhaled particles in man and a comparison with data. IEEE Trans Biomed Eng 1979; 26: 624-30.
44. Yeates D, Gerrity TR, Garrard CS. Particle deposition and clearance in the bronchial tree. Ann Biomed Eng 1981; 9: 577-92.
45. Sackner MA, Yergin BM, Brito M, Januuszkiewicz A. Effect of adrenergic agonists on tracheal mucous velocity. Bull Eur Physiopath Respir 1979; 15: 505-11.
46. Toomes H, Vogt-Moykopf I, Heller WD, Ostertag H. Measurement of mucociliary clearance in smokers and nonsmokers using a bronchoscopic video-technical method. Lung 1981; 159: 27-34.
47. Yeates DB, Gerrity TR, Garrard CS. Characteristics of tracheobronchial deposition and clearance in man. Ann Occup Hyg 1982; 26: 245-57.
48. Asgharian B, Hofmann W, Miller FJ. Mucociliary clearance of insoluble particles from the tracheobronchial airways of the human lung. J Aerosol Sci 2001; 32: 817-32.
49. Sturm R, Hofmann W, Scheuch G, Sommer K, Camner P, Svartengren M. Particle clearance in human bronchial airways: comparison of stochastic model predictions with experimental data. Ann Occup Hyg 2002; 46: S329-33.
50. Hofmann W, Sturm R. Stochastic model of particle clearance in human bronchial airways. J Aerosol Med 2004; 17: 73-89.
51. Sturm R, Hofmann W. A multicompartment model for bronchial clearance of insoluble particles in the human lung. Rad Prot Dosim 2006; 118: 384-94.
52. Stöber W, McClellan RO. Pulmonary retention and clearance of inhaled biopersistent aerosol particles: data-reducing interpolation models and models of physically based systems. Crit Rev Toxicol 1997; 27: 539-98.
53. Stöber W, Morrow PE, Koch W, Morawietz G. Alveolar clearance and retention of inhaled insoluble particles in rats simulated by a model inferring macrophage particle load distributions. J Aerosol Sci 1994; 25: 975-1002.
54. Sturm R, Hofmann W. Mechanistic interpretation of the slow bronchial clearance phase. Rad Prot Dosim 2003; 105: 101-4.
55. Stahlhofen W, Scheuch G, Bailey MR. Measurements of tracheobronchial clearance of particles after aerosol bolus inhalation. Ann Occup Hyg 1994; 38: 189-96.
56. Scheuch G, Stahlhofen W, Heyder J. An approach to deposition and clearance measurements in human airways. J Aerosol Med 1996; 9: 34-41.
57. Hamsen AG, Muggenburg BA, Snipes MB, Bice DE. The role of macrophages in particle translocation from lungs to lymph nodes. Science 1985; 230: 1277-80.
58. Snipes MB, Clem M. Retention of microspheres in the rat lung after intratracheal instillation. Environ Res 1982; 24: 33-41.
59. Sturm R. A computer model for the clearance of insoluble particles from the tracheobronchial tree of the human lung. Comp Biol Med 2007; 37: 680-7.
60. Sturm R, Hofmann W. A theoretical approach to the deposition and clearance of fibers with variable size in the human respiratory tract. J Hazard Mat 2009; 170: 210-21.
61. Rogak SN, Flagan RC, Nguyen HF. The mobility and structure of aerosol agglomerates. Aerosol Sci Technol 1993; 18: 25-47.
62. Davies CN. Particle-fluid interaction. J Aerosol Sci 1979; 10: 477-513.
63. Dahneke B. Slip correction factors for nonspherical bodies - I Introduction and continuum flow. J Aerosol Sci 1973; 4: 139-45.
64. Dahneke B. Slip correction factors for nonspherical bodies - II Free molecular flow. J Aerosol Sci 1973; 4: 147-61.
65. Kasper G. Dynamics and measurement of smokes. I Size characterization of nonspherical particles. Aerosol Sci Technol 1982; 1: 187-99.
66. Kasper G. Dynamics and measurement of smokes. II The aerodynamic diameter of chain aggregates in the transition regime. Aerosol Sci Technol 1982; 1: 201-15.
67. De Carlo PF, Slowik JG, Worsnop DR, Davidovits P, Jimenez JL. Particle morphology and density characterization by combined mobility and aerodynamic diameter measurements. Part 1: theory. Aerosol Sci Technol 2004; 38: 1185-205.
68. Slowik J etal. Particle morphology and density characterization by combined mobility and aerodynamic diameter measurements. Part 2: application to combustion generated soot particles as a function of fuel equivalence ratio. Aerosol Sci Technol 2004; 38: 1206-22.
69. Kops JAMM, Dibbets G, Hermans L, Van de Vate JF. The aerodynamic diameter of branched chain-like aggregates. J Aerosol Sci 1975; 6: 329-30.
70. Oberdörster G. Lung clearance of inhaled insoluble and soluble particles. J Aerosol Med 1988; 1: 289-330.
71. Heyder J, Gebhart J, Rudolf G, Schiller CF, Stahlhofen W. Deposition of particles in the human respiratory tract in the size range 0.005-15μm. J Aerosol Sci 1986; 17: 811-25.