Low expression of progesterone receptor a in intermediate trophoblast of miscarriages

Histology and Histopathology

Volumn 26, Issue 5, 2011, Pages 609-614

  Papamitsou, Theodora ^a   Chatzistamatiou, Maria ^a   Grammatikopoulou, Danai ^a   Papadopoulou, Kyriaki ^a   Lakis, Sotirios ^a   Economou, Zinon ^a   Papadopoulou, Chrisi ^a   Sioga, Antonia ^a  

^a ARISTOTLE UNIVERSITY OF THESSALONIKI   (Greece)

Author keywords

Estrogen receptor A; Intermediate trophoblast; Miscarriage; Progesterone receptor A

Indexed keywords

CYTOKERATIN 7; ESTROGEN RECEPTOR ALPHA; PROGESTERONE RECEPTOR; PROGESTERONE RECEPTOR A; PROLACTIN;

ADULT; ARTICLE; BIOLOGICAL MODEL; BIOSYNTHESIS; CELL NUCLEUS; FEMALE; GENE EXPRESSION REGULATION; HUMAN; IMMUNOHISTOCHEMISTRY; METABOLISM; METHODOLOGY; MIDDLE AGED; PREGNANCY; SPONTANEOUS ABORTION; TROPHOBLAST;

ABORTION, SPONTANEOUS; ADULT; CELL NUCLEUS; ESTROGEN RECEPTOR ALPHA; FEMALE; GENE EXPRESSION REGULATION, DEVELOPMENTAL; HUMANS; IMMUNOHISTOCHEMISTRY; KERATIN-7; MIDDLE AGED; MODELS, BIOLOGICAL; PREGNANCY; PROLACTIN; RECEPTORS, PROGESTERONE; TROPHOBLASTS;

EID: 79960639032     PISSN: 02133911     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (21)

1. Ali S.H., O'Donnell A.L., Balu D., Pohl M.B., Seyler M.J., Mohamed S., Mousa S. and Dandona P. (2000). Estrogen receptor-a in the inhibition of cancer growth and angiogenesis. Cancer Res. 60, 7094-7098.
2. Bukovsky A., Caudle M.R., Cekanova M., Fernando R.I., Wimalasena J., Foster J.S., Henley D.C. and Elder R.F. (2003). Placental expression of estrogen receptor ß and its hormone binding variantcomparison with estrogen receptor a and a role for estrogen receptors in asymmetric division and differentiation of estrogendependent cells. Reprod. Biol. Endocrinol. 1, 36-56.
3. Bukovsky A., Cekanova M., Caudle M.R., Wimalasena J., Foster J.S., Henley D.C. and Elder R.F. (2003). Expression and localization of estrogen receptor-alpha protein in normal and abnormal term placentae and stimulation of trophoblast differentiation by estradiol. Reprod. Biol. Endocrinol. 1, 13.
4. Cartwright J.E., Kenny L.C., Dash P.R., Crocker I.P., Aplin J.D., Baker P.N. and Whitley G.S. (2002). Trophoblast invasion of spiral arteries: A novel in vitro model. Placenta 23, 232-235.
5. Conneely O.M., Mulac-Jericevic B. and Lydon J.P. (2003). Progesterone-dependent regulation of female reproductive activity by two distinct progesterone receptor isoforms. Steroids 68, 771-778.
6. Dey S.K., Lim H., Das S.K., Reese J., Paria B.C., Daikoku T. and Wang H. (2004). Molecular Cues to Implantation. Endocr. Rev. 25, 341-373.
7. De Vivo I., Huggins G.S., Hankinson S.E., Lescault P.J., Boezen M., Colditz G.A. and Hunter D.J. (2002). A functional polymorphism in the promoter of the progesterone receptor gene associated with endometrial cancer risk. Proc. Natl. Acad. Sci. USA 99, 12263-12268.
8. Graham J.D. and Clarke C.L. (1997). Physiological action of progesterone in target tissues. Endocr. Rev. 18, 502-519.
9. Hickman T.N., Shih L.M., Zacur H.A., Kurman R.J., Diener-West M. and Gearhart J.D. (2002). Decreased progesterone receptor expression in the intermediate trophoblastic cells of spontaneous abortions. Fertil. Steril. 77, 1001-1005.
10. Ito K., Utsunomiya H., Yaegashi N. and Sasano H. (2007). Biological roles of estrogen and progesterone in human endometrial carcinoma-new developments in potential endocrine therapy for endometrial cancer. Endocr. J. 54, 667-679.
11. Kastner P., Krust A., Turcotte B., Stropp U., Tora L., Gronemeyer H. and Chambon P. (1990). Two distinct estrogen-regulated promoters generate transcripts encoding the two functionally different human progesterone receptor forms A and B. EMBO J. 9, 1603-1614.
12. Koehler K.F., Helguero L.A., Haldosen L.A., Warner M. and Gustafsson J.A. (2005). Reflections on the discovery and significance of estrogen receptor ß. Endocr. Rev. 26, 465-447.
13. Macklon N.S., Stouffer R.L., Giudice L.C. and Fauser B.C. (2006). The science behind 25 years of ovarian stimulation for in vitro fertilization. Endocr. Rev. 27, 170-207.
14. Matthews J. and Gustafsson J.A. (2003). Estrogen signaling: a subtle balance between ERa and ERß. Mol. Interv. 3, 281-292.
15. Ogle T.F., Dai D., George P. and Mahesh V.B. (1998). Regulation of the progesterone receptor and estrogen receptor in decidua basalis by progesterone and estradiol during pregnancy. Biol. Reprod. 58, 1188-1198.
16. Paige L.A., Christensen D.J., Gron H., Norris J.D., Gottlin E.B., Padilla K.M., Chang C.Y., Ballas L.M., Hamilton P.T., McDonnell D.P. and Fowlkes D.M. (1999). Estrogen receptor (ER) modulators each induce distinct conformational changes in ERa and ERß. Proc. Natl. Acad. Sci. USA 96, 3999-4004.
17. Schiessl B., Mylonas I., Hantschmann P., Kuhn C., Schulze S., Kunze S., Friese K. and Jeschke U. (2005). Expression of endothelial NO synthase, inducible NO synthase, and estrogen receptors alpha and beta in placental tissue of normal, preeclamptic, and intrauterine growth-restricted pregnancies. J. Histochem. Cytochem. 53, 1441-1449.
18. Shao R., Markstrom E., Friberg P.A., Johansson M. and Billig H. (2003). Expression of progesterone receptor (PR) A and B isoforms in mouse granulosa cells: stage dependent PRmediated regulation of apoptosis and cell proliferation. Biol. Reprod. 68, 914-921.
19. Tibbetts T.A., DeMayo F., Rich S., Conneely O.M. and O'Malley B.W. (1999). Progesterone receptors in the thymus are required for thymic involution during pregnancy and for normal fertility. Proc. Natl. Acad. Sci. USA 96, 12021-12026.
20. Vazquez F., Rodriguez-Manzaneque J.C., Lydon J.P., Edwards D.P., O'Malley B.W. and Iruela-Arispe M.L. (1999). Progesterone regulates proliferation of endothelial cells. J. Biol. Chem. 274, 2185-2192
21. Zhao C., Dahlman-Wright K. and Gustafsson J.A. (2008). Estrogen receptor beta: an overview and update. Nucl. Recept. Signal. 6, e003.