Idiopathic hirsutism: Local and peripheral expression of aromatase (CYP19A) and 5α-reductase genes (SRD5A1 and SRD5A2)

Fertility and Sterility

Volumn 96, Issue 2, 2011, Pages 479-482

  Caglayan, A Okay ^a   Dundar, Munis ^a   Tanriverdi, Fatih ^a   Baysal, Nuran A ^a   Unluhizarci, Kursad ^a   Ozkul, Yusuf ^a   Borlu, Murat ^a   Batukan, Cem ^a   Kelestimur, Fahrettin ^a  

^a ERCIYES UNIVERSITY   (Turkey)

Author keywords

5 reductase; aromatase; expression; idiopathic hirsutism

Indexed keywords

AROMATASE; MESSENGER RNA; STEROID 5ALPHA REDUCTASE 1; STEROID 5ALPHA REDUCTASE 2;

ADOLESCENT; ADULT; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; GENE EXPRESSION; HIRSUTISM; HUMAN; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; SKIN BIOPSY; UNIVERSITY HOSPITAL;

3-OXO-5-ALPHA-STEROID 4-DEHYDROGENASE; ADOLESCENT; ADULT; AROMATASE; BIOPSY; CASE-CONTROL STUDIES; CHI-SQUARE DISTRIBUTION; DERMIS; DOWN-REGULATION; FEMALE; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HIRSUTISM; HUMANS; LEUKOCYTES, MONONUCLEAR; MEMBRANE PROTEINS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; TURKEY; YOUNG ADULT;

EID: 79960636526     PISSN: 00150282     EISSN: 15565653     Source Type: Journal    
DOI: 10.1016/j.fertnstert.2011.05.040     Document Type: Article

References (20)

1. R. Azziz, E. Carmina, and M.E. Sawaya Idiopathic hirsutism Endocr Rev 21 2000 347 362 (Pubitemid 32279644)
2. M.A. Sawaya, and A.R. Salita Androgen receptor polymorphisms (CAG repeat lengths) in androgenetic alopecia, hirsutism and acne J Cutan Med Surg 3 1998 9 15
3. R.S. Legro, B. Shahbahrami, R.A. Lobo, and B.W. Kovacs Size polymorphisms of the androgen receptor among female Hispanics and correlation with androgen characteristics Obstet Gynecol 83 1994 701 706 (Pubitemid 24153462)
4. I. Faredin, and I. Toth Metabolism and concentration of androgenic steroids in the abdominal skin of women with idiopathic hirsutism Acta Med Hung 41 1984 19 34
5. K. Unluhizarci, Y. Karababa, F. Bayram, and F. Kelestimur The investigation of insulin resistance in patients with idiopathic hirsutism J Clin Endocrinol Metab 89 2004 2741 2744 (Pubitemid 38766359)
6. V.A. Randall, M.J. Thornton, K. Hamada, and A.G. Messenger Androgen action in cultured dermal papilla cells from human hair follicles Skin Pharmacol 7 1994 20 26 (Pubitemid 24086188)
7. K. Hamada, M.J. Thornton, I. Laing, A.G. Messenger, and V.A. Randall The metabolism of testosterone by dermal papilla cells cultured from human pubic and axillary hair follicles concurs with hair growth in 5α-reductase deficiency J Invest Dermatol 106 1996 1017 1022 (Pubitemid 26153505)
8. E. Carmina, and R.A. Lobo Polycystic ovaries in women with normal menses Am J Med 111 2001 602 606 (Pubitemid 34088069)
9. S.E. Bulun, S. Sebastian, K. Takayama, T. Suzuki, H. Sasano, and M. Shozu The human CYP19 (aromatase P450) gene: update on physiologic roles and genomic organization of promoters J Steroid Biochem Mol Biol 86 2003 219 224 (Pubitemid 37412560)
10. M.P. Philpott, M.R. Green, and T. Kealey Human hair growth in vitro J Cell Sci 97 1990 463 471 (Pubitemid 20374487)
11. P. Serafini, and R.A. Lobo Increased 5-α reductase in idiopathic hirsutism Fertil Steril 43 1985 74 78
12. C. Sultan, S. Lumbroso, F. Paris, C. Jeandel, B. Terouanne, C. Belon, and F. Audran Disorders of androgen action Semin Reprod Med 20 2002 217 228
13. I.O. Oliveira, C. Lhullier, I.S. Brum, and P.M. Spritzer The 5α-reductase type 1, but not type 2, gene is expressed in anagen hairs plucked from the vertex area of the scalp of hirsute women and normal individuals Braz J Med Biol Res 36 2003 1447 1454 (Pubitemid 37322277)
14. P. Skalba, A. Dabkowska-Huć, W. Kazimierczak, A. Samojedny, M.P. Samojedny, and Z. Chełmicki Content of 5-alpha-reductase (type 1 and type 2) mRNA in dermal papillae from the lower abdominal region in women with hirsutism Clin Exp Dermatol 31 2006 564 570 (Pubitemid 43806594)
15. M. Akiyama, L.T. Smith, and K.A. Holbrook Growth factor and growth factor receptor localization in the hair follicle bulge and associated tissue in human fetus J Invest Dermatol 106 1996 391 396 (Pubitemid 26117580)
16. D.M. Danilenko, B.D. Ring, and G.F. Pierce Growth factors and cytokines in hair follicle development and cycling: recent insights from animal models and the potentials for clinical therapy Mol Med Today 2 1996 460 467 (Pubitemid 126820722)
17. M.P. Philpott, D.A. Sanders, and T. Kealey Effects of insulin and insulin-like growth factors on cultured human hair follicle: IGF-I at physiologic concentrations is an important regulator of hair follicle growth in vitro J Invest Dermatol 102 1994 857 861 (Pubitemid 24210379)
18. R. Frajndlich, and P.M. Spritzer Association between ovarian volume and serum insulin levels in ovulatory patients with idiopathic hirsutism Fertil Steril 83 2005 1561 1564 (Pubitemid 40615843)
19. E. Carmina, R.A. Longo, G.B. Rini, and R.A. Lobo Phenotypic variation in hyperandrogenic women influences the finding of abnormal metabolic and cardiovascular risk parameters J Clin Endocrinol Metab 90 2005 2545 2549 (Pubitemid 40686289)
20. W. Chen, D. Thiboutot, and C.C. Zouboulis Cutaneous androgen metabolism: basic research and clinical perspectives J Invest Dermatol 119 2002 992 1007 (Pubitemid 35430476)