WHO absolute fracture risk models (FRAX): Do clinical risk factors improve fracture prediction in older women without osteoporosis?

Journal of Bone and Mineral Research

Volumn 26, Issue 8, 2011, Pages 1774-1782

  Hillier, Teresa A ^a   Cauley, Jane A ^b   Rizzo, Joanne H ^a   Pedula, Kathryn L ^a   Ensrud, Kristine E ^c,d   Bauer, Douglas C ^e   Lui, Li Yung ^e   Vesco, Kimberly K ^a   Black, Dennis M ^e   Donaldson, Meghan G ^e   Leblanc, Erin S ^a   Cummings, Steven R ^e  

^a CENTER FOR HEALTH RESEARCH   (United States)

^b UNIVERSITY OF PITTSBURGH GRADUATE SCHOOL OF PUBLIC HEALTH   (United States)

^c VETERANS AFFAIRS MEDICAL CENTER   (United States)

^d UNIVERSITY OF MINNESOTA MEDICAL SCHOOL   (United States)

^e UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

fracture; osteopenia; osteoporosis; prediction; risk

Indexed keywords

AGED; ARTICLE; BONE DENSITY; BONE MASS; FEMALE; FRAGILITY FRACTURE; HIP FRACTURE; HUMAN; MAJOR CLINICAL STUDY; OSTEOPOROSIS; PREDICTION; PRIMARY PREVENTION; RISK ASSESSMENT; RISK FACTOR; STATISTICAL MODEL;

BONE AND BONES; BONE DENSITY; COHORT STUDIES; FEMALE; FOLLOW-UP STUDIES; FRACTURES, BONE; HUMANS; MODELS, BIOLOGICAL; ORGAN SIZE; OSTEOPOROSIS; PROGNOSIS; RISK FACTORS; WORLD HEALTH ORGANIZATION;

EID: 79960621438     PISSN: 08840431     EISSN: 15234681     Source Type: Journal    
DOI: 10.1002/jbmr.372     Document Type: Article

References (28)

1. Cummings SR, Nevitt MC, Browner WS, et al. Risk factors for hip fracture in white women. Study of Osteoporotic Fractures Research Group. N Engl J Med. 1995; 332: 767-773.
2. Hillier TA, Stone KL, Bauer DC, et al. Evaluating the value of repeat bone mineral density measurement and prediction of fractures in older women: the Study of Osteoporotic Fractures. Arch Intern Med. 2007; 167: 155-160. (Pubitemid 46148062)
3. Siris ES, Chen YT, Abbott TA, et al. Bone mineral density thresholds for pharmacological intervention to prevent fractures. Arch Intern Med. 2004; 164: 1108-1112. (Pubitemid 38668990)
4. Kanis JA, Oden A, Johnell O, et al. The use of clinical risk factors enhances the performance of BMD in the prediction of hip and osteoporotic fractures in men and women. Osteoporos Int. 2007; 18: 1033-1046. (Pubitemid 47020000)
5. Kanis JA, McCloskey EV, Johansson H, Strom O, Borgstrom F, Oden A,. Case finding for the management of osteoporosis with FRAX: assessment and intervention thresholds for the UK. Osteoporos Int. 2008; 19: 1395-1408.
6. Kanis JA, Johnell O, Oden A, Johansson H, McCloskey E,. FRAX and the assessment of fracture probability in men and women from the UK. Osteoporos Int. 2008; 19: 385-397.
7. National Osteoporosis Foundation (NOF) Clinician's guide to prevention and treatment of osteoporosis. Internet [serial online] Available at:. Accessed June 16, 2010.
8. Ensrud KE, Lui LY, Taylor BC, et al. Study of Osteoporotic Fractures Research Group. A comparison of prediction models for fractures in older women: Is more better. Arch Intern Med. 2009; 169: 2087-2094.
9. Steiger P, Cummings SR, Black DM, Spencer NE, Genant HK,. Age-related decrements in bone mineral density in women over 65. J Bone Miner Res. 1992; 7: 625-632.
10. Looker AC, Johnston CC Jr, Wahner HW, et al. Prevalence of low femoral bone density in older U.S. women from NHANES III. J Bone Miner Res. 1995; 10: 796-802.
11. FRAX release notes available at. FRAX Website [serial online] Accessed November 14, 2009.
12. Ettinger B, Black DM, wson-Hughes B, Pressman AR, Melton LJ III., Updated fracture incidence rates for the US version of FRAX(R). Osteoporos Int. 2010; 21: 25-33.
13. DeLong ER, DeLong DM, Clarke-Pearson DL,. Comparing the areas under two or more correlated receiver operating characteristic curves: A nonparametric approach. Biometrics. 1988; 44: 837-845.
14. Rosner B,. Fundamentals of Biostatistics 2nd Edition. PWS Publishers (Duxbury Press), 1982.
15. Altman DG, Bland JM,. Diagnostic tests. 1: Sensitivity and specificity. BMJ. 1994; 308: 1552.
16. Colon-Emeric CS, Lyles KW,. Should there be a fracas over FRAX and other fracture prediction tools?: Comment on "A comparison of prediction models for fractures in older women ". Arch Intern Med. 2009; 169: 2094-2095.
17. Kauffman RP,. ACP Journal Club. Simple models predicted 10-year fracture risk in older women as accurately as more complex FRAX models. Ann Intern Med. 2010; 152: JC3-13.
18. Tremollieres FA, Pouilles JM, Drewniak N, Laparra J, Ribot Dargent-Molina P,. Fracture risk prediction using BMD and clinical risk factors in early postmenopausal women: sensitivity of the WHO FRAX tool. J Bone Miner Res. 2010; 25: 1002-1009.
19. Donaldson MG, Palermo L, Schousboe JT, Ensrud KE, Hochberg MC, Cummings SR,. FRAX and risk of vertebral fractures: the fracture intervention trial. J Bone Miner Res 2009; 24: 1793-1799.
20. MacLean C, Newberry S, Maglione M, et al. Systematic review: Comparative effectiveness of treatments to prevent fractures in men and women with low bone density or osteoporosis. Ann Intern Med. 2008; 148: 197-213. (Pubitemid 351665507)
21. Cauley JA, Robbins J, Chen Z, et al. Effects of estrogen plus progestin on risk of fracture and bone mineral density: The Women's Health Initiative randomized trial. JAMA. 2003; 290: 1729-1738. (Pubitemid 37430623)
22. McClung MR, Geusens P, Miller PD, et al. Effect of risedronate on the risk of hip fracture in elderly women. Hip Intervention Program Study Group. N Engl J Med. 2001; 344: 333-340. (Pubitemid 32107641)
23. Stevenson M, Lloyd Jones M, De Nigris E, Brewer N, Davis S, Oakley J,. A systematic review and economic evaluation of alendronate, etidronate, risedronate, raloxifene and teriparatide for the prevention and treatment of postmenopausal osteoporosis. Health Technol Assess. 2005; 9: 1-160.
24. Cummings SR, Black DM, Thompson DE, et al. Effect of alendronate on risk of fracture in women with low bone density but without vertebral fractures: results from the Fracture Intervention Trial. JAMA. 1998; 280: 2077-2082. (Pubitemid 29014065)
25. Wells GA, Cranney A, Peterson J, et al. Alendronate for the primary and secondary prevention of osteoporotic fractures in postmenopausal women. Cochrane Database Syst Rev. 2008; (1):CD001155.
26. McCloskey EV, Beneton M, Charlesworth D, et al. Clodronate reduces the incidence of fractures in community-dwelling elderly women unselected for osteoporosis: Results of a double-blind, placebo-controlled randomized study. J Bone Miner Res. 2007; 22: 135-141. (Pubitemid 46032606)
27. Donaldson M, Cawthon P, Lui L, et al. Estimates of the proportion of older white women who would be recommended for pharmacologic treatment by the new US National Osteoporosis Foundation guidelines. J Bone Miner Res. 2008; 24: 675-680.
28. Dawson-Hughes B, Tosteson AN, Melton LJ III, et al. Implications of absolute fracture risk assessment for osteoporosis practice guidelines in the USA. Osteoporos Int. 2008; 19: 449-458.