Adding aripiprazole to clozapine worsened delusions and hallucinations: A case report

Journal of Clinical Psychopharmacology

Volumn 31, Issue 4, 2011, Pages 528-531

  Avari, Jimmy ^a   Mahgoub, Nahla ^a   Alexopoulos, George S ^a  

^a WEILL CORNELL MEDICAL COLLEGE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARIPIPRAZOLE; CLOZAPINE; NEUROLEPTIC AGENT; THIORIDAZINE;

ADULT; BLEPHAROSPASM; CASE REPORT; DELUSION; DISEASE EXACERBATION; DRUG MEGADOSE; DRUG WITHDRAWAL; FEMALE; HALLUCINATION; HUMAN; LETTER; PARANOID SCHIZOPHRENIA; PRIORITY JOURNAL; PSYCHOTHERAPY;

CLOZAPINE; DELUSIONS; DRUG THERAPY, COMBINATION; FEMALE; HALLUCINATIONS; HUMANS; MIDDLE AGED; PIPERAZINES; QUINOLONES; SCHIZOPHRENIA, PARANOID;

EID: 79960607294     PISSN: 02710749     EISSN: 1533712X     Source Type: Journal    
DOI: 10.1097/JCP.0b013e3182223b13     Document Type: Letter

References (14)

1. Chan J, Sweeting M. Review: combination therapy with non-clozapine atypical antipsychotic medication: a review of current evidence. J Psychopharmacol. 2007;21(6):657-664. (Pubitemid 47472722)
2. Crismon ML, DeLeon A, Miller AL. Aripiprazole: does partial dopaminergic agonism translate into clinical benefits? Ann Pharmacother. 2003;37:738-740. (Pubitemid 36523072)
3. Chang JS, Ahn YM, Park HJ, et al. Aripiprazole augmentation in clozapine-treated patients with refractory schizophrenia: an 8 week, randomized, double-blind, placebo-controlled trial. J Clin Psychiatry. 2008;69(5): 720-731. (Pubitemid 351838681)
4. Clarke LA, Lindenmayer JP, Kaushik S. Clozapine augmentation with aripiprazole for negative symptoms. J Clin Psychiatry. 2006;67(4):675-676. (Pubitemid 43764249)
5. Abu-Tair F, Kopitz J, Bergemann N. Clozapine augmented with aripiprazole in 5 patients with schizophrenia. J Clin Psychopharmacol. 2006;26(6):669-671. (Pubitemid 44772751)
6. Chiu YH, Chen CH, Lu ML. Worsening psychosis after adding aripiprazole to clozapine. Prog Neuropsychopharmacol Biol Psychiatry. 2011;35:291-292.
7. DeQuardo JR. Worsened agitation with aripiprazole: adverse effect of dopamine partial agonism? J Clin Psychiatry. 2004;65(1):132-133.
8. Reeves RR, Mack JE. Worsening schizoaffective disorder with aripiprazole. Am J Psychiatry. 2004;161(7):1308.
9. Ahuja N, Lloyd AJ. Aripiprazole and worsening of psychosis: a case report. J Clin Psychiatry. 2007;68(5): 805-806. (Pubitemid 46841875)
10. Ramaswamy S, Vijad D, William M, et al. Aripiprazole possibly worsens psychosis. Int Clin Psychopharmacol. 2004;19(1):45-48. (Pubitemid 38114625)
11. Adan-Manes J, Garcia-Parajua P. Aripiprazole in combination with other antipsychotic drugs may worsen psychosis. J Clin Pharm Ther. 2009;34(2):245-246.
12. Kane JM, Correll CU, Goff DC, et al. A multicenter, randomized, double-blind, placebo-controlled, 16-week study of adjunctive aripiprazole for schizophrenia or schizoaffective disorder inadequately treated with quetiapine or risperidone monotherapy. J Clin Psychiatry. 2009;70(10):1348-1357.
13. Fleischhacker WW, Heikkinen ME, Olié JP, et al. Effects of adjunctive treatment with aripiprazole on body weight and clinical efficacy in schizophrenia patients treated with clozapine: a randomized, double-blind, placebo-controlled trial. Int J Neuropsychopharmacol. 2010;13(8):1115-1125.
14. Gurevich EV, Bordelon Y, Shapiro RM, et al. Mesolimbic dopamine D3 receptors and use of antipsychotics in patients with schizophrenia: a postmortem study. Arch Gen Psychiatry. 1997;54(3): 225-232. (Pubitemid 27132051)