Synthesis of 9-(heteroarylmethylidene)amino derivatives of homocamptothecin with biological activities

Chemistry and Biodiversity

Volumn 8, Issue 7, 2011, Pages 1266-1273

  Guo, Wei ^a   Miao, Zhenyuan ^a   Sheng, Chunquan ^a   Yao, Jianzhong ^a   Liu, Wenfeng ^a   Zhu, Lingjian ^a   Zhang, Yongqiang ^a   Cheng, Pengfei ^a   Dong, Guoqiang ^a   Zhuang, Chunlin ^a   Zhang, Wannian ^a  

^a SECOND MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

Antitumor activity; Cytotoxic activity; Homocamptothecin derivatives; Inhibitors; Topoisomerase I inhibiton

Indexed keywords

9 (2 PYRIDYLMETHYLIDENE)AMINOHOMOCAMPTOTHECIN; 9 (3 PYRIDYLMETHYLIDENE)AMINOHOMOCAMPTOTHECIN; 9 (4 PYRIDYLMETHYLIDENE)AMINOHOMOCAMPTOTHECIN; 9 (FURYLMETHYLIDENE)AMINOHOMOCAMPTOTHECIN; 9 (PHENYLMETHYLIDENE)AMINOHOMOCAMPTOTHECIN; 9 (THIENYLMETHYLIDENE)AMINOHOMOCAMPTOTHECIN; ANTINEOPLASTIC AGENT; CAMPTOTHECIN DERIVATIVE; DNA TOPOISOMERASE; ENZYME INHIBITOR; TOPOTECAN; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; BIOLOGICAL ACTIVITY; CONTROLLED STUDY; CYTOTOXICITY; DNA CLEAVAGE; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; HUMAN; HUMAN CELL; LUNG CANCER; MOLECULAR DOCKING; SPECTROSCOPY; TUMOR CELL LINE;

ANTINEOPLASTIC AGENTS; CAMPTOTHECIN; CELL LINE, TUMOR; CELL PROLIFERATION; DNA TOPOISOMERASES, TYPE I; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; NEOPLASMS; TOPOISOMERASE I INHIBITORS;

EID: 79960575547     PISSN: 16121872     EISSN: 16121880     Source Type: Journal    
DOI: 10.1002/cbdv.201000271     Document Type: Article

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