Escitalopram oxalate, a selective serotonin reuptake inhibitor, exhibits cytotoxic and apoptotic effects in glioma C6 cells

Acta Neuropsychiatrica

Volumn 23, Issue 4, 2011, Pages 173-178

  Dikmen, Miriş ^a   Cantürk, Zerrin ^a   Öztürk, Yusuf ^a  

^a ANADOLU UNIVERSITY   (Turkey)

Author keywords

C6 glioma; escitalopram oxalate; flow cytometry; NIH3T3

Indexed keywords

3 (4,5 DIMETHYL 2 THIAZOLYL) 2,5 DIPHENYLTETRAZOLIUM BROMIDE; ESCITALOPRAM; LIPOCORTIN 5; PROPIDIUM IODIDE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CELL PROLIFERATION; CELL STRAIN 3T3; CONTROLLED STUDY; CYTOTOXICITY; DRUG EFFICACY; FLOW CYTOMETRY; GLIOMA CELL; IN VITRO STUDY; INCUBATION TIME; NONHUMAN; RAT;

EID: 79960565712     PISSN: 09242708     EISSN: 16015215     Source Type: Journal    
DOI: 10.1111/j.1601-5215.2011.00550.x     Document Type: Article

References (33)

1. Chang SM, Prados MD., Chemotherapy for gliomas. Curr Opin Oncol 1995; 7: 207-213.
2. Newton HB., Primary brain tumors, review of etiology, diagnosis and treatment. Am Fam Physician 1994; 49: 787-797. (Pubitemid 24085070)
3. Lieberman A., Depression in Parkinson's disease. Acta Neurol Scand 2006; 113: 1-8.
4. Tutton PJM, Barkla DH., Influence of inhibitors of serotonin uptake on intestinal epithelium and colorectal carcinomas. Br J Cancer 1982; 46: 260-265. (Pubitemid 12053078)
5. Tsuruo T, Lida H, Nojiri M, Tsukagoshi S, Sakurai Y., Potentiation of chemotherapeutic effect of vincristine in vincristine resistant tumor bearing mice by calmodulin inhibitor clomipramine. J Pharmacobiodyn 1983; 6: 145-147. (Pubitemid 13107953)
6. Sauter C., Cytostatic activity of commonly used tricyclic antidepressants. Oncology 1989; 46: 155-157. (Pubitemid 19117307)
7. Merry S, Hamilton TG, Flanigan P, Freshney RI, Kaye SB., Circumvention of pleiotropic drug resistance in subcutaneous tumors in vivo with verapamil and clomipramine. Eur J Cancer 1991; 27: 31-34.
8. Pommerenke EW, Volm M., Reversal of doxorubicin-resistance in solid tumors by clomipramine. In Vivo 1995; 9: 99-102.
9. Stafford RS, MacDonald EA, Finkelstein SN., National patterns of medication treatment for depression. Prim Care Companion J Clin Psychiatry 2001; 3: 232-235. (Pubitemid 33807565)
10. Wyllie AH., Glucocorticoid-induced thymocyte apoptosis is associated with endogenous endonuclease activation. Nature 1980; 284: 555-556. (Pubitemid 10070336)
11. Thompson CB., Apoptosis in the pathogenesis and treatment of disease. Science 1995; 267: 1456-1462.
12. Chiou SH, Chen SJ, Peng CH, et al., Fluoxetine up-regulation expression of cellular FLICE-inhibitory protein and inhibits LPS-induced apoptosis in hippocampus-derived stem cell. Biochem Biophys Res Commun 2006; 343: 391-400.
13. Kolla N, Wei Z, Richardson JS, Li XM., Amitriptyline and fluoxetine protects PC12 cells from cell death induced by hydrogen peroxide. J Psychiatry Neurosci 2005; 30: 196-201. (Pubitemid 40942458)
14. Youdim MBH, Bakhle YS., Monoamine oxidase: isoforms and inhibitors in Parkinson's disease and depressive illness. Br J Pharmacol 2006; 147: 287-296.
15. Murphy DL, Mitchell PB, Potter WZ., Novel pharmacological approaches to the treatment of depression. In:, Bloom FE, Kupfer DL, eds. Psychophamacology: the fourth generation of progress. New York: Raven Press, 1995: 1143-1153.
16. Naoi M, Maruyama W, Akao Y, Yi H, Yamaoka Y., Involvement of type A monoamine oxidase in neurodegeneration: regulation of mitochondrial signaling leading to cell death or neuroprotection. J Neural Transm 2006; 71: 67-77. (Pubitemid 351412108)
17. Levkovitz Y, Gil-Ad I, Zeldich E, Dayag M, Weizman A., Differential induction of apoptosis by antidepressants in glioma and neuroblastoma cell lines: evidence for p-c-Jun, cytochrome c, and caspase-3 involvement. J Mol Neurosci 2005; 27: 29-42. (Pubitemid 41112377)
18. Abdul M, Logothetis CJ, Hoosein NM., Growth inhibitory effects of serotonin uptake inhibitors on human prostate carcinoma cell lines. J Urol 1995; 154: 247-250.
19. Xia Z, Bergstrand A, DePierre JW, Nassberger L., The antidepressants imipramine, clomipramine, and citalopram induce apoptosis in human acute myeloid leukemia HL-60 cells via caspase-3 activation. J Biochem Mol Toxicol 1999; 13: 338-347. (Pubitemid 129705411)
20. Serafeim A, Holder MJ, Grafton G, et al., Selective serotonin reuptake inhibitors directly signal for apoptosis in biopsy-like Burkitt lymphoma cells. Blood 2003; 101: 3212-3219. (Pubitemid 36858017)
21. Serafeim A, Grafton G, Chamba A, et al., 5-Hydroxytryptamine drives apoptosis in biopsylike Burkitt lymphoma cells: reversal by selective serotonin reuptake inhibitors. Blood 2002; 99: 2545-2553. (Pubitemid 34525444)
22. Meredith EJ, Holder MJ, Chamba A, et al., The serotonin transporter (SLC6A4) is present in B-cell clones of diverse malignant origin: probing a potential antitumor target for psychotropics. FASEB J 2005; 19: 1187-1189. (Pubitemid 40946460)
23. Fotakis G, Timbrell JA., In vitro cytotoxicity assays: comparison of LDH, neutral red, MTT and protein assay in hepatoma cell lines following exposure to cadmium chloride. Toxicol Lett 2006; 160: 171-177. (Pubitemid 41578961)
24. Mosmann T., Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J Immunol Methods 1983; 65: 55-63. (Pubitemid 14203433)
25. Belkaid A, Copland IB, Massillon D, Annabi B., Silencing of the human microsomal glucose-6-phosphate translocase induces glioblastoma cells death: potential new target for the anticancer curcumin. FEBS Lett 2006; 580: 3746-3752. (Pubitemid 43902814)
26. Atsumi T, Tonosaki K, Fujisawa S., Induction of early apoptosis and ROS-generation activity in human gingival fibroblasts (HGF) and human submandibular gland carcinoma (HSG) cells treated with curcumin. Arch Oral Biol 2006; 51: 913-921. (Pubitemid 44373839)
27. Levkovitz Y, Gil-Ad I, Zeldich E, Dayag M, Weizman A., Differential induction of apoptosis by antidepressants in glioma and neuroblastoma cell lines. J Mol Neurosci 2005; 27: 29-42.
28. Arimochi H, Morita K., Characterization of cytotoxic actions of tricyclic antidepressants on human HT29 colon carcinoma cells. Eur J Pharmacol 2006; 541: 17-23. (Pubitemid 43903472)
29. Volpe DA, Ellison CD, Parchment RE, Grieshaber CK, Faustino PJ., Effects of amitriptyline and fluoxetine upon the in vitro proliferation of tumor cell lines. J Exp Ther Oncol 2003; 3: 169-184. (Pubitemid 37214795)
30. Peer D, Margalit R., Fluoxetine and reversal of multidrug resistance. Cancer Lett 2006; 237: 180-187. (Pubitemid 43777079)
31. Parker KA, Pilkington GJ., Apoptosis of human malignant glioma-derived cell cultures treated with clomipramine hydrochloride, as detected by Annexin-V assay. Radiol Oncol 2006; 40: 87-93. (Pubitemid 44147428)
32. Xia Z, DePierre JW, Nassberger L., Modulation of apoptosis induced by tricyclic antidepressants in human peripheral lymphocytes. J Biochem Mol Toxicol 1998; 12: 115-123. (Pubitemid 128480784)
33. Xia Z, Lundgren B, Bergstrand A, DePierre JW, Nässberger L., Changes in the generation of reactive oxygen species and in mitochondrial membrane potential during apoptosis induced by the antidepressants imipramine, clomipramine, and citalopram and the effects on these changes by Bcl-2 and Bcl-X(L). Biochem Pharmacol 1999; 57: 1199-1208. (Pubitemid 29171696)