Candidate tumour suppressor Fau regulates apoptosis in human cells: An essential role for Bcl-G

Biochimica et Biophysica Acta - Molecular Basis of Disease

Volumn 1812, Issue 9, 2011, Pages 1146-1153

  Pickard, Mark R ^a   Mourtada Maarabouni, Mirna ^a   Williams, Gwyn T ^a  

^a KEELE UNIVERSITY   (United Kingdom)

Author keywords

Apoptosis; Bcl 2 family; BCL L14; FUBI; Oncogenesis; Tumour suppressor

Indexed keywords

FAU PROTEIN; MESSENGER RNA; PROTEIN BCL G; SMALL INTERFERING RNA; TUMOR SUPPRESSOR PROTEIN; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; BREAST TUMOR; CONTROLLED STUDY; COVALENT BOND; DOWN REGULATION; GENE EXPRESSION; GENE SILENCING; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROGNOSIS; PROSTATE TUMOR; REGULATORY MECHANISM; RNA INTERFERENCE; T LYMPHOCYTE; ULTRAVIOLET C RADIATION;

APOPTOSIS; GENE KNOCKDOWN TECHNIQUES; GENE SILENCING; HEK293 CELLS; HUMANS; JURKAT CELLS; PROTO-ONCOGENE PROTEINS C-BCL-2; RIBOSOMAL PROTEINS; TUMOR SUPPRESSOR PROTEINS; ULTRAVIOLET RAYS;

EID: 79960563678     PISSN: 09254439     EISSN: 1879260X     Source Type: Journal    
DOI: 10.1016/j.bbadis.2011.04.009     Document Type: Article

References (28)

1. Michiels L., Vanderrauwelaert E., Vanhasselt F., Kas K., Merregaert J. Fau cDNA encodes a ubiquitin-like-S30 fusion protein and is expressed as an antisense sequence in the Finkel-Biskis-Reilly murine sarcoma-virus. Oncogene 1993, 8:2537-2546.
2. Rossman T.G., Wang Z.L. Expression cloning for arsenite-resistance resulted in isolation of tumor-suppressor fau cDNA: possible involvement of the ubiquitin system in arsenic carcinogenesis. Carcinogenesis 1999, 20:311-316.
3. Rossman T.G., Visalli M.A., Komissarova E.V. Fau and its ubiquitin-like domain (FUBI) transforms human osteogenic sarcoma (HOS) cells to anchorage-independence. Oncogene 2003, 22:1817-1821.
4. Kas K., Michiels L., Merregaert J. Genomic structure and expression of the human Fau gene - encoding the ribosomal-pProtein S30 Fused to a ubiquitin-like protein. Biochem. Biophys. Res. Commun. 1992, 187:927-933.
5. Nakamura M., Tsunematsu T., Tanigawa Y. TCR-alpha chain-like molecule is involved in the mechanism of antigen-non-specific suppression of a ubiquitin-like protein. Immunology 1998, 94:142-148.
6. Nakamura M., Tanigawa Y. Noncovalent interaction of MNSFbeta, a ubiquitin-like protein, with histone 2A. Comp. Biochem. Physiol. B Biochem. Mol. Biol. 2005, 140:207-210.
7. Nakamura M., Tanigawa Y. Characterization of ubiquitin-like polypeptide acceptor protein, a novel pro-apoptotic member of the Bcl2 family. Eur. J. Biochem. 2003, 270:4052-4058.
8. Nakamura M., Yamaguchi S. The ubiquitin-like protein MNSF beta regulates ERK-MAPK cascade. J. Biol. Chem. 2006, 281:16861-16869.
9. Guo B., Godzik A., Reed J.C. Bcl-G, a novel pro-apoptotic member of the Bcl-2 family. J. Biol. Chem. 2001, 276:2780-2785.
10. Mourtada-Maarabouni M., Kirkham L., Farzaneh F., Williams G.T. Regulation of apoptosis by Fau revealed by functional expression cloning and antisense expression. Oncogene 2004, 23:9419-9426.
11. Williams G.T. Programmed cell-death - apoptosis and oncogenesis. Cell 1991, 65:1097-1098.
12. Cory S., Huang D.C.S., Adams J.M. The Bcl-2 family: roles in cell survival and oncogenesis. Oncogene 2003, 22:8590-8607.
13. Pickard M.R., Green A.R., Ellis I.O., Caldas C., Hedge V.L., Mourtada-Maarabouni M., Williams G.T. Dysregulated expression of Fau and MELK is associated with poor prognosis in breast cancer. Breast Cancer Res. 2009, 11:R60.
14. Pickard M.R., Edwards S.E., Cooper C.S., Williams G.T. Apoptosis regulators Fau and Bcl-G are down-regulated in prostate cancer. Prostate 2010, 70:1513-1523.
15. Moss E.L., Mourtada-Maarabouni M., Pickard M.R., Redman C.W., Williams G.T. FAU regulates carboplatin resistance in ovarian cancer. Genes Chromosomes Cancer 2010, 49:70-77.
16. Williams G.T., Critchlow M.R., Hedge V.L., O'Hare K.B. Molecular failure of apoptosis: inappropriate cell survival and mutagenesis?. Toxicol. Lett. 1998, 103:485-489.
17. Mourtada-Maarabouni M., Hedge V.L., Kirkham L., Farzaneh F., Williams G.T. Growth arrest in human T-cells is controlled by the non-coding RNA growth-arrest-specific transcript 5 (GAS5). J. Cell Sci. 2008, 121:939-946.
18. Kerscher O., Felberbaum R., Hochstrasser M. Modification of proteins by ubiquitin and ubiquitin-like proteins. Annu. Rev. Cell Dev. Biol. 2006, 22:159-180.
19. Thompson S.J., Loftus L.T., Ashley M.D., Meller R. Ubiquitin-proteasome system as a modulator of cell fate. Curr. Opin. Pharmacol. 2008, 8:90-95.
20. Bader M., Steller H. Regulation of cell death by the ubiquitin-proteasome system. Curr. Opin. Cell Biol. 2009, 21:878-884.
21. Broemer M., Meier P. Ubiquitin-mediated regulation of apoptosis. Trends Cell Biol. 2009, 19:130-140.
22. Miled C., Pontoglio M., Garbay S., Yaniv M., Weitzman J.B. A genomic map of p53 binding sites identifies novel p53 targets involved in an apoptotic network. Cancer Res. 2005, 65:5096-5104.
23. Wojcik C. Proteasomes in apoptosis: villains or guardians?. Cell. Mol. Life Sci. 1999, 56:908-917.
24. Raasi S., Schmidtke G., Groettrup M. The ubiquitin-like protein FAT10 forms covalent conjugates and induces apoptosis. J. Biol. Chem. 2001, 276:35334-35343.
25. Ross M.J., Wosnitzer M.S., Ross M.D., Granelli B., Gusella G.L., Husain M., Kaufman L., Vasievich M., D'Agati V.D., Wilson P.D., Klotman M.E., Klotman P.E. Role of ubiquitin-like protein FAT10 in epithelial apoptosis in renal disease. J. Am. Soc. Nephrol. 2006, 17:996-1004.
26. Snyder A., Alsauskas Z., Gong P., Rosenstiel P.E., Klotman M.E., Klotman P.E., Ross M.J. FAT10: a novel mediator of Vpr-induced apoptosis in human immunodeficiency virus-associated nephropathy. J. Virol. 2009, 83:11983-11988.
27. Welchman R.L., Gordon C., Mayer R.J. Ubiquitin and ubiquitin-like proteins as multifunctional signals. Nat. Rev. Mol. Cell Biol. 2005, 6:599-609.
28. Sun Y.-F., Yu L.-Y., Saarma M., Timmusk T., Arumae U. Neuron-specific Bcl-2 homology 3 domain-only splice variant of Bak is anti-apoptotic in neurons, but pro-apoptotic in non-neuronal cells. J. Biol. Chem. 2001, 276:16240-16247.