DNA methylation plays an important role in promoter choice and protein production at the mouse Dnmt3L locus

Developmental Biology

Volumn 356, Issue 2, 2011, Pages 411-420

  O'Doherty, Alan M ^a,c   Rutledge, Charlotte E ^a   Sato, Shun ^b   Thakur, Avinash ^a   Lees Murdock, Diane J ^a   Hata, Kenichiro ^b   Walsh, Colum P ^a  

^a UNIVERSITY OF ULSTER   (United Kingdom)

^b NATIONAL RESEARCH INSTITUTE FOR CHILD HEALTH AND DEVELOPMENT   (Japan)

^c UNIVERSITY COLLEGE DUBLIN   (Ireland)

Author keywords

DNA methylation; Imprinting; Mouse; Oocytes; Sperm

Indexed keywords

DNA METHYLTRANSFERASE 3 LIKE PROTEIN; UNCLASSIFIED DRUG;

AIRE GENE; ANIMAL CELL; ARTICLE; CELL DIFFERENTIATION; CONTROLLED STUDY; CPG ISLAND; DNA METHYLATION; FEMALE; GENE; GENE LOCUS; GENE REPRESSION; GENE SILENCING; GENOME IMPRINTING; GERM CELL; INTRON; MOUSE; NONHUMAN; OOCYTE; OOCYTE DEVELOPMENT; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN PROCESSING; PROTEIN SYNTHESIS; STEM CELL; TESTIS;

MUS;

EID: 79960563172     PISSN: 00121606     EISSN: 1095564X     Source Type: Journal    
DOI: 10.1016/j.ydbio.2011.05.665     Document Type: Article

References (35)

1. Aapola U., Maenpaa K., Kaipia A., Peterson P. Epigenetic modifications affect Dnmt3L expression. Biochem. J. 2004, 380:705-713.
2. Beard C., Li E., Jaenisch R. Loss of methylation activates Xist in somatic but not in embryonic cells. Genes Dev. 1995, 9:2325-2334.
3. Borgel J., Guibert S., Li Y., Chiba H., Schubeler D., Sasaki H., Forne T., Weber M. Targets and dynamics of promoter DNA methylation during early mouse development. Nat. Genet. 2010, 42:1093-1100.
4. Bourc'his D., Bestor T.H. Meiotic catastrophe and retrotransposon reactivation in male germ cells lacking Dnmt3L. Nature 2004, 431:96-99.
5. Bourc'his D., Xu G.L., Lin C.S., Bollman B., Bestor T.H. Dnmt3L and the establishment of maternal genomic imprints. Science 2001, 294:2536-2539.
6. Bustin S.A. Absolute quantification of mRNA using real-time reverse transcription polymerase chain reaction assays. J. Mol. Endocrinol. 2000, 25:169-193.
7. Chedin F., Lieber M.R., Hsieh C.L. The DNA methyltransferase-like protein DNMT3L stimulates de novo methylation by Dnmt3a. Proc. Natl Acad. Sci. U. S. A. 2002, 99:16916-16921.
8. Chotalia M., Smallwood S.A., Ruf N., Dawson C., Lucifero D., Frontera M., James K., Dean W., Kelsey G. Transcription is required for establishment of germline methylation marks at imprinted genes. Genes Dev. 2009, 23:105-117.
9. Ciccone D.N., Su H., Hevi S., Gay F., Lei H., Bajko J., Xu G., Li E., Chen T. KDM1B is a histone H3K4 demethylase required to establish maternal genomic imprints. Nature 2009, 461:415-418.
10. Davis T.L., Trasler J.M., Moss S.B., Yang G.J., Bartolomei M.S. Acquisition of the H19 methylation imprint occurs differentially on the parental alleles during spermatogenesis. Genomics 1999, 58:18-28.
11. Davis T.L., Yang G.J., McCarrey J.R., Bartolomei M.S. The H19 methylation imprint is erased and re-established differentially on the parental alleles during male germ cell development. Hum. Mol. Genet. 2000, 9:2885-2894.
12. Dobbin E., Corrigan P.M., Walsh C.P., Welham M.J., Freeburn R.W., Wheadon H. Tel/PDGFRbeta inhibits self-renewal and directs myelomonocytic differentiation of ES cells. Leuk. Res. 2008, 32:1554-1564.
13. Hata K., Okano M., Lei H., Li E. Dnmt3L cooperates with the Dnmt3 family of de novo DNA methyltransferases to establish maternal imprints in mice. Development 2002, 129:1983-1993.
14. Hata K., Kusumi M., Yokomine T., Li E., Sasaki H. Meiotic and epigenetic aberrations in Dnmt3L-deficient male germ cells. Mol. Reprod. Dev. 2006, 73:116-122.
15. Hu Y.G., Hirasawa R., Hu J.L., Hata K., Li C.L., Jin Y., Chen T., Li E., Rigolet M., Viegas-Pequignot E., Sasaki H., Xu G.L. Regulation of DNA methylation activity through Dnmt3L promoter methylation by Dnmt3 enzymes in embryonic development. Hum. Mol. Genet. 2008, 17:2654-2664.
16. Hu J.L., Zhang R.R., Zhang K.L., Zhou J.Q., Xu G.L. The N-terminus of histone H3 is required for de novo DNA methylation in chromatin. Proc. Natl. Acad. Sci. U.S.A. 2009, 106:22187-22192.
17. Hukkanen J., Vaisanen T., Lassila A., Piipari R., Anttila S., Pelkonen O., Raunio H., Hakkola J. Regulation of CYP3A5 by glucocorticoids and cigarette smoke in human lung-derived cells. J. Pharmacol. Exp. Ther. 2003, 304:745-752.
18. Illingworth R.S., Gruenewald-Schneider U., Webb S., Kerr A.R., James K.D., Turner D.J., Smith C., Harrison D.J., Andrews R., Bird A.P. Orphan CpG islands identify numerous conserved promoters in the mammalian genome. PLoS Genet. 2010, 6:e1001134.
19. Jia D., Jurkowska R.Z., Zhang X., Jeltsch A., Cheng X. Structure of Dnmt3a bound to Dnmt3L suggests a model for de novo DNA methylation. Nature 2007, 449:248-251.
20. Lees-Murdock D.J., Walsh C.P. DNA methylation reprogramming in the germ line. Epigenetics 2008, 3:5-13.
21. Lees-Murdock D.J., Lau H.T., Castrillon D.H., De Felici M., Walsh C.P. DNA methyltransferase loading, but not de novo methylation, is an oocyte-autonomous process stimulated by SCF signalling. Dev. Biol. 2008, 321:238-250.
22. Li E., Beard C., Jaenisch R. Role for DNA methylation in genomic imprinting. Nature 1993, 366:362-365.
23. Li J.Y., Lees-Murdock D.J., Xu G.L., Walsh C.P. Timing of establishment of paternal methylation imprints in the mouse. Genomics 2004, 84:952-960.
24. Lucifero D., Mertineit C., Clarke H.J., Bestor T.H., Trasler J.M. Methylation dynamics of imprinted genes in mouse germ cells. Genomics 2002, 79:530-538.
25. Maatouk D.M., Kellam L.D., Mann M.R., Lei H., Li E., Bartolomei M.S., Resnick J.L. DNA methylation is a primary mechanism for silencing postmigratory primordial germ cell genes in both germ cell and somatic cell lineages. Development 2006, 133:3411-3418.
26. Maunakea A.K., Nagarajan R.P., Bilenky M., Ballinger T.J., D'Souza C., Fouse S.D., Johnson B.E., Hong C., Nielsen C., Zhao Y., Turecki G., Delaney A., Varhol R., Thiessen N., Shchors K., Heine V.M., Rowitch D.H., Xing X., Fiore C., Schillebeeckx M., Jones S.J., Haussler D., Marra M.A., Hirst M., Wang T., Costello J.F. Conserved role of intragenic DNA methylation in regulating alternative promoters. Nature 2010, 466:253-257.
27. Meissner A., Mikkelsen T.S., Gu H., Wernig M., Hanna J., Sivachenko A., Zhang X., Bernstein B.E., Nusbaum C., Jaffe D.B., Gnirke A., Jaenisch R., Lander E.S. Genome-scale DNA methylation maps of pluripotent and differentiated cells. Nature 2008, 454:766-770.
28. Mertineit C., Yoder J.A., Taketo T., Laird D.W., Trasler J.M., Bestor T.H. Sex-specific exons control DNA methyltransferase in mammalian germ cells. Development 1998, 125:889-897.
29. Ooi S.K., Qiu C., Bernstein E., Li K., Jia D., Yang Z., Erdjument-Bromage H., Tempst P., Lin S.P., Allis C.D., Cheng X., Bestor T.H. DNMT3L connects unmethylated lysine 4 of histone H3 to de novo methylation of DNA. Nature 2007, 448:714-717.
30. Shovlin T.C., Bourc'his D., La Salle S., O'Doherty A., Trasler J.M., Bestor T.H., Walsh C.P. Sex-specific promoters regulate Dnmt3L expression in mouse germ cells. Hum. Reprod. 2007, 22:457-467.
31. Sunnotel O., Hiripi L., Lagan K., McDaid J.R., De Leon J.M., Miyagawa Y., Crowe H., Kaluskar S., Ward M., Scullion C., Campbell A., Downes C.S., Hirst D., Barton D., Mocanu E., Tsujimura A., Cox M.B., Robson T., Walsh C.P. Alterations in the steroid hormone receptor co-chaperone FKBPL are associated with male infertility: A case-control study. Reprod. Biol. Endocrinol. 2010, 8:22.
32. Walsh C.P., Bestor T.H. Cytosine methylation and mammalian development. Genes Dev. 1999, 13:26-34.
33. Walsh C.P., Chaillet J.R., Bestor T.H. Transcription of IAP endogenous retroviruses is constrained by cytosine methylation. Nat. Genet. 1998, 20:116-117.
34. Weber M., Hellmann I., Stadler M.B., Ramos L., Paabo S., Rebhan M., Schubeler D. Distribution, silencing potential and evolutionary impact of promoter DNA methylation in the human genome. Nat. Genet. 2007, 39:457-466.
35. Webster K.E., O'Bryan M.K., Fletcher S., Crewther P.E., Aapola U., Craig J., Harrison D.K., Aung H., Phutikanit N., Lyle R., Meachem S.J., Antonarakis S.E., de Kretser D.M., Hedger M.P., Peterson P., Carroll B.J., Scott H.S. Meiotic and epigenetic defects in Dnmt3L-knockout mouse spermatogenesis. Proc. Natl Acad. Sci. U. S. A. 2005, 102:4068-4073.