Toxoplasma gondii aspartic protease 1 is not essential in tachyzoites

Experimental Parasitology

Volumn 128, Issue 4, 2011, Pages 454-459

  Polonais, Valerie ^a   Shea, Michael ^b   Soldati Favre, Dominique ^a  

^a UNIVERSITY OF GENEVA   (Switzerland)

^b NATIONAL INSTITUTE FOR MEDICAL RESEARCH   (United Kingdom)

Author keywords

Aspartic protease; Plasmepsin; Toxoplasma gondii

Indexed keywords

ASPARTIC PROTEASE 1; ASPARTIC PROTEINASE; UNCLASSIFIED DRUG;

ARTICLE; ASPARTIC PROTEASE 1 GENE; BIOGENESIS; CELL MEMBRANE; CONTROLLED STUDY; GENE; GENE DELETION; GENE DISRUPTION; GENE SILENCING; HUMAN; HUMAN CELL; MEMBRANE FORMATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; TACHYZOITE; TOXOPLASMA GONDII;

ANIMALS; ASPARTIC ACID ENDOPEPTIDASES; CELLS, CULTURED; CERCOPITHECUS AETHIOPS; GENE DELETION; GENE KNOCKOUT TECHNIQUES; HUMANS; TOXOPLASMA; VERO CELLS;

COCCIDIA; TOXOPLASMA GONDII;

EID: 79960561149     PISSN: 00144894     EISSN: 10902449     Source Type: Journal    
DOI: 10.1016/j.exppara.2011.05.003     Document Type: Article

References (26)

1. Bermudes D., Dubremetz J.F., Achbarou A., Joiner K.A. Cloning of a cDNA encoding the dense granule protein GRA3 from Toxoplasma gondii. Molecular and Biochemical Parasitology 1994, 68:247-257.
2. Boddey J.A., Hodder A.N., Gunther S., Gilson P.R., Patsiouras H., Kapp E.A., Pearce J.A., de Koning-Ward T.F., Simpson R.J., Crabb B.S., Cowman A.F. An aspartyl protease directs malaria effector proteins to the host cell. Nature 2010, 463:627-631.
3. Bonilla J.A., Bonilla T.D., Yowell C.A., Fujioka H., Dame J.B. Critical roles for the digestive vacuole plasmepsins of Plasmodium falciparum in vacuolar function. Molecular Microbiology 2007, 65:64-75.
4. Boyle J.P., Radke J.R. A history of studies that examine the interactions of Toxoplasma with its host cell: emphasis on in vitro models. International Journal for Parasitology 2009, 39:903-914.
5. Brossier F., Starnes G.L., Beatty W.L., Sibley L.D. Microneme rhomboid protease TgROM1 is required for efficient intracellular growth of Toxoplasma gondii. Eukaryotic Cell 2008, 7:664-674.
6. Carruthers V.B. Proteolysis and Toxoplasma invasion. International Journal for Parasitology 2006, 36:595-600.
7. Donald R.G., Carter D., Ullman B., Roos D.S. Insertional tagging, cloning, and expression of the Toxoplasma gondii hypoxanthine-xanthine-guanine phosphoribosyltransferase gene. Use as a selectable marker for stable transformation. The Journal Biological Chemistry 1996, 271:14010-14019.
8. Drew M.E., Banerjee R., Uffman E.W., Gilbertson S., Rosenthal P.J., Goldberg D.E. Plasmodium food vacuole plasmepsins are activated by falcipains. The Journal Biological Chemistry 2008, 283:12870-12876.
9. Dubremetz J.F. Rhoptries are major players in Toxoplasma gondii invasion and host cell interaction. Cellular Microbiology 2007, 9:841-848.
10. Gilk S.D., Raviv Y., Hu K., Murray J.M., Beckers C.J., Ward G.E. Identification of PhIL1, a novel cytoskeletal protein of the Toxoplasma gondii pellicle, through photosensitized labeling with 5-[125I]iodonaphthalene-1-azide. Eukaryotic Cell 2006, 5:1622-1634.
11. Gubbels M.J., Vaishnava S., Boot N., Dubremetz J.F., Striepen B. A MORN-repeat protein is a dynamic component of the Toxoplasma gondii cell division apparatus. Journal of Cell Science 2006, 119:2236-2245.
12. Heaslip, A.T., Dzierszinski, F., Stein, B., Hu, K., 2010. TgMORN1 is a key organizer for the basal complex of Toxoplasma gondii. PLoS Pathogens 6, e1000754.
13. Hoegl L., Korting H.C., Klebe G. Inhibitors of aspartic proteases in human diseases: molecular modeling comes of age. Pharmazie 1999, 54:319-329.
14. Hu K., Johnson J., Florens L., Fraunholz M., Suravajjala S., DiLullo C., Yates J., Roos D.S., Murray J.M. Cytoskeletal components of an invasion machine - the apical complex of Toxoplasma gondii. PLoS Pathogens 2006, 2:e13.
15. Kim K., Soldati D., Boothroyd J.C. Gene replacement in Toxoplasma gondii with chloramphenicol acetyltransferase as selectable marker. Science 1993, 262:911-914.
16. Larson E.T., Parussini F., Huynh M.H., Giebel J.D., Kelley A.M., Zhang L., Bogyo M., Merritt E.A., Carruthers V.B. Toxoplasma gondii cathepsin L is the primary target of the invasion-inhibitory compound morpholinurea-leucyl-homophenyl-vinyl sulfone phenyl. The Journal of Biological Chemistry 2009, 284:26839-26850.
17. Le Bonniec S., Deregnaucourt C., Redeker V., Banerjee R., Grellier P., Goldberg D.E., Schrevel J. Plasmepsin II, an acidic hemoglobinase from the Plasmodium falciparum food vacuole, is active at neutral pH on the host erythrocyte membrane skeleton. The Journal of Biological Chemistry 1999, 274:14218-14223.
18. Li F., Patra K.P., Yowell C.A., Dame J.B., Chin K., Vinetz J.M. Apical surface expression of aspartic protease Plasmepsin 4, a potential transmission-blocking target of the Plasmodium ookinete. The Journal of Biological Chemistry 2010, 285:8076-8083.
19. Naglik J.R., Challacombe S.J., Hube B. Candida albicans secreted aspartyl proteinases in virulence and pathogenesis. Microbiology and Molecular Biology Reviews 2003, 67:400-428.
20. Nelson M.M., Jones A.R., Carmen J.C., Sinai A.P., Burchmore R., Wastling J.M. Modulation of the host cell proteome by the intracellular apicomplexan parasite Toxoplasma gondii. Infection and Immunity 2008, 76:828-844.
21. Pelletier L., Stern C.A., Pypaert M., Sheff D., Ngo H.M., Roper N., He C.Y., Hu K., Toomre D., Coppens I., Roos D.S., Joiner K.A., Warren G. Golgi biogenesis in Toxoplasma gondii. Nature 2002, 418:548-552.
22. Plattner F., Yarovinsky F., Romero S., Didry D., Carlier M.F., Sher A., Soldati-Favre D. Toxoplasma profilin is essential for host cell invasion and TLR11-dependent induction of an interleukin-12 response. Cell Host and Microbe 2008, 3:77-87.
23. Russo I., Babbitt S., Muralidharan V., Butler T., Oksman A., Goldberg D.E. Plasmepsin V licenses Plasmodium proteins for export into the host erythrocyte. Nature 2010, 463:632-636.
24. Shea M., Jakle U., Liu Q., Berry C., Joiner K.A., Soldati-Favre D. A family of aspartic proteases and a novel, dynamic and cell-cycle-dependent protease localization in the secretory pathway of Toxoplasma gondii. Traffic 2007, 8:1018-1034.
25. Soldati D., Boothroyd J.C. Transient transfection and expression in the obligate intracellular parasite Toxoplasma gondii. Science 1993, 260:349-352.
26. Wlodawer A., Vondrasek J. Inhibitors of HIV-1 protease: a major success of structure-assisted drug design. Annual Review of Biophysics and Biomolecular Structure 1998, 27:249-284.