Inhibitors of aspartic proteases in human diseases: Molecular modeling comes of age

Pharmazie

Volumn 54, Issue 5, 1999, Pages 319-329

  Hoegl, L ^b   Korting, Hans C ^a   Klebe, G ^b  

^a LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

4 CYCLOHEXYL 2 HYDROXY 3 [N [3 (MORPHOLINOCARBONYL) 2 (1 NAPHTHYLMETHYL)PROPIONYL]HISTIDYLAMINO]BUTYRIC ACID ISOPROPYL ESTER; A 74273; AMPRENAVIR; ASPARTIC PROTEINASE INHIBITOR; CGP 38560; DITEKIREN; ENALKIREN; FK 906; GR 70982; INDINAVIR; KNI 227; L 687; L 908; N [3 MORPHOLINOCARBONYL 2 (1 NAPHTHYLMETHYL)PROPIONYL] 3 (4 THIAZOLYL)ALANYLCYCLOSTATINE N (2 MORPHOLINOETHYL)AMIDE; N MORPHOLINOACETYL[3 (1 NAPHTHYL)ALANYL][3 (4 THIAZOLYL)ALANYL] 4 AMINO 5 CYCLOHEXYL 3 HYDROXYPENTANOIC ACID HEXYLAMIDE; NELFINAVIR; NORSTATINE; PD 132002; PD 134672; PROTEINASE INHIBITOR; REMIKIREN; RENIN INHIBITOR; RITONAVIR; SAQUINAVIR; SR 43385; SR 43845; STATINE; TERLAKIREN; U 81749; UNCLASSIFIED DRUG; UNINDEXED DRUG; ZANKIREN;

ANTIBIOTIC RESISTANCE; ANTIHYPERTENSIVE ACTIVITY; ANTIMICROBIAL ACTIVITY; CANDIDA ALBICANS; DOSE RESPONSE; DRUG DESIGN; DRUG DISPOSITION; DRUG INDUCED DISEASE; DRUG MECHANISM; DRUG POTENCY; DRUG PROTEIN BINDING; DRUG SPECIFICITY; DRUG STRUCTURE; DRUG TOLERABILITY; ENZYME CONFORMATION; HUMAN; MOLECULAR MODEL; NONHUMAN; QUANTITATIVE STRUCTURE ACTIVITY RELATION; REVIEW; SPECIES DIFFERENCE; STRUCTURE ANALYSIS;

ASPARTIC ENDOPEPTIDASES; HUMANS; MODELS, MOLECULAR; PROTEASE INHIBITORS;

EID: 0032933051     PISSN: 00317144     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

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