Naegleria gruberi metabolism

International Journal for Parasitology

Volumn 41, Issue 9, 2011, Pages 915-924

  Opperdoes, Fred R ^a   De Jonckheere, Johan F ^a,b   Tielens, Aloysius G M ^c  

^a DE DUVE INSTITUTE   (Belgium)

^b SCIENTIFIC INSTITUTE OF PUBLIC HEALTH   (Belgium)

^c ERASMUS MEDICAL CENTER   (Netherlands)

Author keywords

Amino acids; Carbohydrate metabolism; Drugs; Hydrogenosome; Lipids; Mitochondrion; Purines; Pyrimidines

Indexed keywords

ACETIC ACID; ALCOHOL; AMINO ACID; AMPHOTERICIN B; BENZNIDAZOLE; CARBOHYDRATE; CARBON DIOXIDE; CYTOCHROME; DITHIOL DERIVATIVE; FLUCONAZOLE; IRON; IRON HYDROGENASE; ITRACONAZOLE; KETOCONAZOLE; LACTIC ACID; MICONAZOLE; NIFURTIMOX; NYSTATIN; OXYGEN; PENTOSE; PHOSPHATE; PURINE; PYRIMIDINE; PYRUVATE SYNTHASE; RIFAMPICIN; SALICYLHYDROXAMIC ACID; SUCCINIC ACID; SULFUR; UNINDEXED DRUG; VITAMIN;

AMINO ACID; CARBOHYDRATE; CARBON DIOXIDE; CYTOCHROME; DRUG; EUKARYOTE; GENOME; GENOMICS; LIPID; METABOLISM; MITOCHONDRION; PATHOGEN;

AFRICAN TRYPANOSOMIASIS; AMINO ACID METABOLISM; AMINO TERMINAL SEQUENCE; CARBOHYDRATE METABOLISM; CARBOXY TERMINAL SEQUENCE; CELL TRANSPORT; CHAGAS DISEASE; DRUG EFFICACY; DRUG TARGETING; ENERGY METABOLISM; GENOME; HUMAN; LIPID METABOLISM; MICROBIAL METABOLISM; MITOCHONDRION; NAEGLERIA GRUBERI; NONHUMAN; NUCLEOTIDE SEQUENCE; PEROXISOME; PHAGOCYTOSIS; PREDICTION; PRIMARY AMEBIC MENINGOENCEPHALITIS; REVIEW; TRYPANOSOMIASIS;

ANTIPROTOZOAL AGENTS; HUMANS; NAEGLERIA; PROTOZOAN INFECTIONS; PROTOZOAN PROTEINS;

NAEGLERIA; NAEGLERIA FOWLERI; NAEGLERIA GRUBERI;

EID: 79960557561     PISSN: 00207519     EISSN: 18790135     Source Type: Journal    
DOI: 10.1016/j.ijpara.2011.04.004     Document Type: Review

References (70)

1. Bot C., Hall B.S., Bashir N., Taylor M.C., Helsby N.A., Wilkinson S.R. Trypanocidal activity of aziridinyl nitrobenzamide prodrugs. Antimicrob. Agents Chemother. 2010, 54:4246-4252.
2. Bringaud F., Baltz D., Baltz T. Functional and molecular characterization of a glycosomal PPi-dependent enzyme in trypanosomatids: pyruvate, phosphate dikinase. Proc. Natl. Acad. Sci. USA 1998, 95:7963-7968.
3. Brandt U. Energy converting NADH:quinone oxidoreductase (complex I). Annu. Rev. Biochem. 2006, 75:69-92.
4. Cáceres A.J., Quiñones W., Gualdrón M., Cordeiro A., Avilán L., Michels P.A., Concepción J.L. Molecular and biochemical characterization of novel glucokinases from Trypanosoma cruzi and Leishmania spp. Mol. Biochem. Parasitol. 2007, 156:235-245.
5. Calvo S.E., Mootha V.K. The mitochondrial proteome and human disease. Annu. Rev. Genomics Hum. Genet. 2010, 11:25-44.
6. Davidson E.A., van der Giezen M., Horner D.S., Embley T.M., Howe C.J. An [Fe] hydrogenase from the anaerobic hydrogenosome-containing fungus Neocallimastix frontalis L2. Gene 2002, 296:45-52.
7. de Graaf R.M., Duarte I., van Alen T.A., Kuiper J.W., Schotanus K., Rosenberg J., Huynen M.A., Hackstein J.H. The hydrogenosomes of Psalteriomonas lanterna. BMC Evol. 2009, 9:287.
8. De Jonckheere J.F. A century of research on the amoeboflagellate genus Naegleria. Acta Protozool. 2002, 41:309-342.
9. De Jonckheere J.F. Molecular definition and the ubiquity of species in the genus Naegleria. Protist 2004, 155:89-103.
10. Elbein A.D., Pan Y.T., Pastuszak I., Carroll D. New insights on trehalose: a multifunctional molecule. Glycobiology 2003, 13:17R-27R.
11. Embley T.M., Martin W. Eukaryotic evolution, changes and challenges. Nature 2006, 440:623-630.
12. Fritz-Laylin L.K., Ginger M.L., Walsh C., Dawson S.C., Fulton C. The Naegleria genome: A free-living microbial eukaryote lends unique insights into core eukaryotic cell biology. Res. Microbiol. 2011, 5:1. Epub ahead of print.
13. Fritz-Laylin L.K., Prochnik S.E., Ginger M.L., Dacks J.B., Carpenter M.L., Field M.C., Kuo A., Paredez A., Chapman J., Pham J., Shu S., Neupane R., Cipriano M., Mancuso J., Tu H., Salamov A., Lindquist E., Shapiro H., Lucas S., Grigoriev I.V., Cande W.Z., Fulton C., Rokhsar D.S., Dawson S.C. The genome of Naegleria gruberi illuminates early eukaryotic versatility. Cell 2010, 140:631-642.
14. Fulton C. Amoeboflagellates as research partners: the laboratory biology of Naegleria and Tetramitus. Methods in Cell Physiology 1970, vol. 4:341-476. Academic Press, New York and London.
15. Fulton C., Webster C., Wu J.S. Chemically defined media for cultivation of Naegleria gruberi. Proc. Natl. Acad. Sci. USA 1984, 81:2406-2410.
16. Gabaldón T., Rainey D., Huynen M.A. Tracing the evolution of a large protein complex in the eukaryotes, NADH:ubiquinone oxidoreductase (complex I). J. Mol. Biol. 2005, 348:857-870.
17. Galland N., Michels P.A. Comparison of the peroxisomal matrix protein import system of different organisms. Exploration of possibilities for developing inhibitors of the import system of trypanosomatids for anti-parasite chemotherapy. Eur. J. Cell Biol. 2010, 89:621-637.
18. Ginger M.L., Fritz-Laylin L.K., Fulton C., Cande W.Z., Dawson S.C. Intermediary metabolism in protists: a sequence-based view of facultative anaerobic metabolism in evolutionarily diverse eukaryotes. Protist 2010, 161:642-671.
19. Gottschalk G. Bacterial Metabolism, second ed 1985, Springer Verlag, New York and Berlin, 359pp., 265-266.
20. Gray M.W. Origin and evolution of organelle genomes. Curr. Opin. Genet. Dev. 1993, 3:884-890.
21. Gray M.W., Lang B.F., Burger G. Mitochondria of protists. Annu. Rev. Genet. 2004, 38:477-524.
22. Hall B.S., Wu X., Hu L., Wilkinson S.R. Exploiting the drug-activating properties of a novel trypanosomal nitroreductase. Antimicrob. Agents Chemother. 2010, 54:1193-1199.
23. Hannaert V., Saavedra E., Duffieux F., Szikora J.P., Rigden D.J., Michels P.A., Opperdoes F.R. Plant-like traits associated with metabolism of Trypanosoma parasites. Proc. Natl. Acad. Sci. USA 2003, 100:1067-1071.
24. Henze K., Horner D.S., Suguri S., Moore D.V., Sánchez L.B., Müller M., Embley T.M. Unique phylogenetic relationships of glucokinase and glucose phosphate isomerase of the amitochondriate eukaryotes Giardia intestinalis, Spironucleus barkhanus and Trichomonas vaginalis. Gene 2001, 281:123-131.
25. Kofoid C.A. On the relative numbers of rhizopods and flagellates in the fauna of soils. Science 1915, 42:937-940.
26. Kurland C.G., Andersson S.G. Origin and evolution of the mitochondrial proteome. Microbiol. Mol. Biol. Rev. 2000, 64:786-820.
27. Lang B.F., Burger G., O'Kelly C.J., Cedergren R., Golding G.B., Lemieux C., Sankoff D., Turmel M., Gray M.W. An ancestral mitochondrial DNA resembling a eubacterial genome in miniature. Nature 1997, 387:493-497.
28. Laloi M. Plant mitochondrial carriers: an overview. Cell. Mol. Life Sci. 1999, 56:918-944.
29. Lill R. Function and biogenesis of iron-sulphur proteins. Nature 2009, 460:831-838.
30. Lill R., Mühlenhoff U. Maturation of iron-sulfur proteins in eukaryotes: mechanisms connected processes, and diseases. Annu. Rev. Biochem. 2008, 77:669-700.
31. Lu Q., McAlister-Henn L. Peroxisomal localization and function of NADP+ -specific isocitrate dehydrogenases in yeast. Arch. Biochem. Biophys. 2009, 493:125-134.
32. Mertens E., De Jonckheere J., Van Schaftingen E. Pyrophosphate-dependent phosphofructokinase from the amoeba Naegleria fowleri, an AMP-sensitive enzyme. Biochem. J. 1993, 292:797-803.
33. Nara T., Hshimoto T., Aoki T. Evolutionary implications of the mosaic pyrimidine-biosynthetic pathway in eukaryotes. Gene 2000, 257:209-222.
34. Nerad T.A., Visvesvara G., Daggett P.M. Chemically defined media for the cultivation of Naegleria: pathogenic and high temperature tolerant species. J. Protozool. 1983, 30:383-387.
35. Ondarza R.N., Hurtado G., Tamayo E., Iturbe A., Hernández E. Naegleria fowleri: a free-living highly pathogenic amoeba contains trypanothione/trypanothione reductase and glutathione/glutathione reductase systems. Exp. Parasitol. 2006, 114:141-146.
36. Opperdoes F.R., Aarsen P.N., van der Meer C., Borst P. Trypanosoma brucei: an evaluation of salicylhydroxamic acid as a trypanocidal drug. Exp. Parasitol. 1976, 40:198-205.
37. Opperdoes F.R., Michels P.A.M. Horizontal gene transfer in trypanosomatids. Trends Parasitol. 2007, 23:470-476.
38. Opperdoes F.R., Michels P.A.M. Complex I of Trypanosomatidae: does it exist?. Trends Parasitol. 2008, 24:310-317.
39. Opperdoes F.R., Szikora J.P. In silico prediction of the glycosomal enzymes of Leishmania major and trypanosomes. Mol. Biochem. Parasitol. 2006, 147:193-206.
40. Oza S.L., Tetaud E., Ariyanayagam M.R., Warnon S.S., Fairlamb A.H. A single enzyme catalyses formation of Trypanothione from glutathione and spermidine in Trypanosoma cruzi. J. Biol. Chem. 2002, 277:35853-35861.
41. Palmieri L., Runswick M.J., Fiermonte G., Walker J.E., Palmieri F. Yeast mitochondrial carriers: bacterial expression, biochemical identification and metabolic significance. J. Bioenerg. Biomembr. 2000, 32:67-77.
42. Poungvarin N., Jariya P. The fifth nonlethal case of primary amoebic meningoencephalitis. J. Med. Assoc. Thai. 1991, 74:112-115.
43. Priya M., Haridas A., Manilal V.B. Anaerobic protozoa and their growth in biomethanation systems. Biodegradation 2008, 19:179-185.
44. Raederstorff D., Rohmer M. Sterol biosynthesis via cycloartenol and other biochemical features related to photosynthetic phyla in the amoeba Naegleria lovaniensis and Naegleria gruberi. Eur. J. Biochem. 1987, 164:427-434.
45. Rucktäschel R., Girzalsky W., Erdmann R. Protein import machineries of peroxisomes. Biochim. Biophys. Acta 2011, 1808:892-900.
46. Schuster F.L., Visvesvara G.S. Free-living amoebae as opportunistic and non-opportunistic pathogens of humans and animals. Int. J. Parasitol. 2004, 34:1001-1027.
47. Seidel J.S., Harmatz P., Visvesvara G.S., Cohen A., Edwards J., Turner J. Successful treatment of primary amebic meningoencephalitis. N. Engl. J. Med. 1982, 30:346-348.
48. Shiflett A.M., Johnson P.J. Mitochondrion-related organelles in eukaryotic protists. Annu. Rev. Microbiol. 2010, 64:409-429.
49. Silhavy T.J., Kahne D., Walker S. The bacterial cell envelope. Cold Spring Harb. Perspect. Biol. 2010, 2:a000414. (Epub 2010 Apr 14).
50. Stechmann A., Cavalier-Smith T. Rooting the eukaryote tree by using a derived gene fusion. Science 2002, 297:89-91.
51. Steinbüchel A., Müller M. Anaerobic pyruvate metabolism of Tritrichomonas foetus and Trichomonas vaginalis hydrogenosomes. Mol. Biochem. Parasitol. 1986, 20:57-65.
52. Tielens A.G.M., van den Heuvel J.M., van den Bergh S.G. Differences in intermediary energy metabolism between juvenile and adult Fasciola hepatica. Mol. Biochem. Parasitol. 1987, 24:273-281.
53. Tielens A.G.M., Rotte C., van Hellemond J.J., Martin W. Mitochondria as we don't know them. Trends Biochem. Sci. 2002, 27:564-572.
54. Tielens A.G.M., van Grinsven K.W., Henze K., van Hellemond J.J., Martin W. Acetate formation in the energy metabolism of parasitic helminths and protists. Int. J. Parasitol. 2010, 40:387-397.
55. Vargas-Zepeda J., Gomez-Alcala A.V., Vazques-Morales J.A., Licea-Amaya L., De Jonckheere J.F., Lares-Villa F. Succesful treatment of Naegleria fowleri meningoencephalitis by using intravenous Amphotericin B, Fluconazole and Rifampicin. Case report. Arch. Med. Res. 2005, 36:83-86.
56. Van den Berghe G., Bontemps F., Vincent M.F., Van den Bergh F. The purinenucleotide cycle and its molecular defects. Prog. Neurobiol. 1992, 39:547-561.
57. van Grinsven K.W., van Hellemond J.J., Tielens A.G.M. Acetate:succinate CoA-transferase in the anaerobic mitochondria of Fasciola hepatica. Mol. Biochem. Parasitol. 2009, 164:74-79.
58. van Hellemond J.J., van der Klei A., van Weelden S.W., Tielens A.G.M. Biochemical and evolutionary aspects of anaerobically functioning mitochondria. Philos. Trans. R. Soc. Lond. B Biol. Sci. 2003, 358:205-213.
59. Van Hellemond J.J., Opperdoes F.R., Tielens A.G.M. Trypanosomatidae produce acetate via a mitochondrial acetate:succinate CoA-transferase. Proc. Natl. Acad. Sci. USA 1998, 95:3036-3041.
60. Van Schaftingen E. Fructose 2,6-bisphosphate. Adv. Enzymol. Relat. Areas Mol. Biol. 1987, 59:315-395.
61. Varela-Gómez M., Moreno-Sánchez R., Pardo J.P., Perez-Montfort R. Kinetic mechanism and metabolic role of pyruvate phosphate dikinase from Entamoeba histolytica. J. Biol. Chem. 2004, 279:54124-54130.
62. Veiga-da-Cunha M., Sokolova T., Opperdoes F., Van Schaftingen E. Evolution of vertebrate glucokinase regulatory protein from a bacterial N-acetylmuramate 6-phosphate etherase. Biochem. J. 2009, 423:323-332.
63. Visvesvara G.S., Moura H., Schuster F.L. Pathogenic and opportunistic free-living amoebae: Acanthamoeba spp., Balamuthia mandrillaris, Naegleria fowleri, and Sappinia diploidea. FEMS Immunol. Med. Microbiol. 2007, 50:1-26.
64. Vollmer W., Blanot D., de Pedro M.A. Peptidoglycan structure and architecture. FEMS Microbiol. Rev. 2008, 32:149-167.
65. Weik R.R., John D.T. Cell and mitochondria respiration of Naegleria fowleri. J. Parasitol. 1979, 65:700-708.
66. Wilkinson S.R., Taylor M.C., Horn D., Kelly J.M., Cheeseman I. A mechanism for cross-resistance to nifurtimox and benznidazole in trypanosomes. Proc. Natl. Acad. Sci. USA 2008, 105:5022-5027.
67. Wu G., Henze K., Müller M. Evolutionary relationships of the glucokinase from the amitochondriate protist, Trichomonas vaginalis. Gene 2001, 264:265-271.
68. Wyllie S., Fairlamb A.H. Methylglyoxal metabolism in trypanosomes and leishmania. Semin. Cell. Dev. Biol. 2011, 22:271-277.
69. Yabu Y., Suzuki T., Nihei C., Minagawa N., Hosokawa T., Nagai K., Kita K., Ohta N. Chemotherapeutic efficacy of ascofuranone in Trypanosoma vivax-infected mice without glycerol. Parasitol. Int. 2006, 55:39-43.
70. Yoshihara T., Hamamoto T., Munakata R., Tajiri R., Ohsumi M., Yokota S. Localization of cytosolic NADP-dependent isocitrate dehydrogenase in the peroxisomes of rat liver cells: biochemical and immunocytochemical studies. J. Histochem. Cytochem. 2001, 49:1123-1131.