Repeat Stool Testing to Diagnose Clostridium difficile Infection Using Enzyme Immunoassay Does Not Increase Diagnostic Yield

Clinical Gastroenterology and Hepatology

Volumn 9, Issue 8, 2011, Pages

  Deshpande, Abhishek ^a   Pasupuleti, Vinay ^a   Patel, Preethi ^a   Ajani, Gati ^a   Hall, Geraldine ^a   Hu, Bo ^a   Jain, Anil ^a   Rolston, David D K ^b  

^a LERNER RESEARCH INSTITUTE   (United States)

^b GEISINGER MEDICAL CENTER   (United States)

Author keywords

Bacteria; Diagnostic Utility; Hospital Acquired Infection; Sensitivity

Indexed keywords

CLOSTRIDIUM DIFFICILE TOXIN A; CLOSTRIDIUM DIFFICILE TOXIN B;

ADULT; ARTICLE; CLOSTRIDIUM DIFFICILE; CLOSTRIDIUM DIFFICILE INFECTION; DIAGNOSTIC ACCURACY; DIAGNOSTIC VALUE; DIARRHEA; ENZYME IMMUNOASSAY; FALSE NEGATIVE RESULT; FECES ANALYSIS; FEMALE; HUMAN; MAJOR CLINICAL STUDY; MALE; PRACTICE GUIDELINE; PREDICTIVE VALUE; REPEAT PROCEDURE; SENSITIVITY AND SPECIFICITY;

EID: 79960557102     PISSN: 15423565     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cgh.2011.04.030     Document Type: Article

References (29)

1. Gerding D.N., Johnson S., Peterson L.R., et al. Clostridium difficile-associated diarrhea and colitis. Infect Control Hosp Epidemiol 1995, 16:459-477.
2. Deshpande A., Pant C., Jain A., et al. Do fluoroquinolones predispose patients to Clostridium difficile associated disease?. A review of the evidence. Curr Med Res Opin 2008, 24:329-333.
3. Jarvis W.R., Schlosser J., Jarvis A.A., et al. National point prevalence of Clostridium difficile in US health care facility inpatients. Am J Infect Control 2008, 2009:263-270.
4. Planche T., Aghaizu A., Holliman R., et al. Diagnosis of Clostridium difficile infection by toxin detection kits: a systematic review. Lancet Infect Dis 2008, 8:777-784.
5. Loo V.G., Poirier L., Miller M.A., et al. A predominantly clonal multi-institutional outbreak of Clostridium difficile-associated diarrhea with high morbidity and mortality. N Engl J Med 2005, 353:2442-2449.
6. Luo R.F., Banaei N. Is repeat PCR needed for diagnosis of Clostridium difficile infection?. J Clin Microbiol 2010, 48:3738-3741.
7. Nemat H., Khan R., Ashraf M.S., et al. Diagnostic value of repeated enzyme immunoassays in Clostridium difficile infection. Am J Gastroenterol 2009, 104:2035-2041.
8. Blossom D.B., McDonald L.C. The challenges posed by reemerging Clostridium difficile infection. Clin Infect Dis 2007, 45:222-227.
9. Snell H., Ramos M., Longo S., et al. Performance of the TechLab C. DIFF CHEK-60 enzyme immunoassay (EIA) in combination with the C. difficile Tox A/B II EIA kit, the Triage C. difficile panel immunoassay, and a cytotoxin assay for diagnosis of Clostridium difficile-associated diarrhea. J Clin Microbiol 2004, 42:4863-4865.
10. Manabe Y.C., Vinetz J.M., Moore R.D., et al. Clostridium difficile colitis: an efficient clinical approach to diagnosis. Ann Intern Med 1995, 123:835-840.
11. Bartlett J.G. Clinical practice. Antibiotic-associated diarrhea. N Engl J Med 2002, 346:334-339.
12. Debast S.B., van Kregten E., Oskam K.M., et al. Effect on diagnostic yield of repeated stool testing during outbreaks of Clostridium difficile-associated disease. Clin Microbiol Infect 2008, 14:622-624.
13. Arabi Z., Boxwalla A. Repeated stool toxin testing for diagnosing difficile colitis is still valid. South Med J 2009, 102:993-994.
14. Mohan S.S., McDermott B.P., Parchuri S., et al. Lack of value of repeat stool testing for Clostridium difficile toxin. Am J Med 2006, 119:e7-e8.
15. Cardona D.M., Rand K.H. Evaluation of repeat Clostridium difficile enzyme immunoassay testing. J Clin Microbiol 2008, 46:3686-3689.
16. Drees M., Snydman D.R., O'Sullivan C.E. Repeated enzyme immunoassays have limited utility in diagnosing Clostridium difficile. Eur J Clin Microbiol Infect Dis 2008, 27:397-399.
17. Gade R., Turett G. The utility of repeated stool toxin testing for diagnosing Clostridium difficile colitis. South Med J 2009, 102:1007-1009.
18. Morelli M.S., Rouster S.D., Giannella R.A., et al. Clinical application of polymerase chain reaction to diagnose Clostridium difficile in hospitalized patients with diarrhea. Clin Gastroenterol Hepatol 2004, 2:669-674.
19. Aichinger E., Schleck C.D., Harmsen W.S., et al. Nonutility of repeat laboratory testing for detection of Clostridium difficile by use of PCR or enzyme immunoassay. J Clin Microbiol 2008, 46:3795-3797.
20. Bélanger S.D., Boissinot M., Clairoux N., et al. Rapid detection of Clostridium difficile in feces by real-time PCR. J Clin Microbiol 2003, 41:730-734.
21. Guilbault C., Labbé A.C., Poirier L., et al. Development and evaluation of a PCR method for detection of the Clostridium difficile toxin B gene in stool specimens. J Clin Microbiol 2002, 40:2288-2290.
22. Sloan L.M., Duresko B.J., Gustafson D.R., et al. Comparison of real-time PCR for detection of the tcdC gene with four toxin immunoassays and culture in diagnosis of Clostridium difficile infection. J Clin Microbiol 2008, 46:1996-2001.
23. van den Berg R.J., Kuijper E.J., van Coppenraet L.E., et al. Rapid diagnosis of toxinogenic Clostridium difficile in faecal samples with internally controlled real-time PCR. Clin Microbiol Infect 2006, 12:184-186.
24. Deshpande A., Pasupuleti V., Pant C., et al. Potential value of repeat stool testing for Clostridium difficile stool toxin using enzyme immunoassay?. Curr Med Res Opin 2010, 26:2635-2641.
25. Cohen S.H., Gerding D.N., Johnson S., et al. Clinical practice guidelines for Clostridium difficile infection in adults: 2010 update by the Society for Healthcare Epidemiology of America (SHEA) and the infectious diseases society of America (IDSA). Infect Control Hosp Epidemiol 2010, 31:431-455.
26. Rolny P., Järnerot G., Möllby R. Occurrence of Clostridium difficile toxin in inflammatory bowel disease. Scand J Gastroenterol 1983, 18:61-64.
27. Jodorkovsky D., Young Y., Abreu M.T. Clinical outcomes of patients with ulcerative colitis and co-existing Clostridium difficile infection. Dig Dis Sci 2010, 55:415-420.
28. Subramanian V. Clostridium difficile and inflammatory bowel disease: implications for current clinical practice. F1000 Med Rep 2009, 1:pii25.
29. Gerding D.N., Muto C.A., Owens R.C. Treatment of Clostridium difficile infection. Clin Infect Dis 2008, 46:S32-S42.