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Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

Volumn 879, Issue 23, 2011, Pages 2201-2205

A simple HPLC method for plasma level monitoring of mitotane and its two main metabolites in adrenocortical cancer patients

(3) Garg, Madhu B a,b Sakoff, Jennette A a,c,d Ackland, Stephen P a,b,d

a CALVARY MATER NEWCASTLE HOSPITAL (Australia)

b UNIVERSITY OF NEWCASTLE (Australia)

c UNIVERSITY OF NEWCASTLE (Australia)

d HUNTER MEDICAL RESEARCH INSTITUTE (Australia)

Author keywords

Adrenocortical cancer; HPLC; Metabolites; Mitotane

Indexed keywords

ADRENOCORTICAL CANCER; CANCER PATIENTS; ETHANOL EXTRACTION; EXTRACTION EFFICIENCIES; HPLC; HPLC METHOD; INTERNAL STANDARDS; ISOCRATIC ELUTION; LIMITS OF QUANTITATIONS; MITOTANE; MOBILE PHASE; PARENT COMPOUNDS; PHARMACOKINETICS AND PHARMACODYNAMICS; PLASMA LEVELS; REPRODUCIBILITIES; REVERSED PHASE; UV DETECTION;

ACETIC ACID; BIOMOLECULES; DISEASES; ETHANE; ETHANOL; ETHYLENE; EXTRACTION; METABOLISM; METABOLITES; PATIENT TREATMENT;

HIGH PERFORMANCE LIQUID CHROMATOGRAPHY;

2,4' 1,1 (2,4' DICHLORODIPHENYL)ACETIC ACID; 2,4' 1,1 DICHLORO 2 (4 CHLOROPHENYL) 2 (2 CHLOROPHENYL)ETHENE; 4,4' 1,1 (2,4' DICHLORODIPHENYL)ACETIC ACID; 4,4' 1,1 DICHLORO 2,2 BIS(4 CHLOROPHENYL)ETHANE; ALCOHOL; DRUG METABOLITE; MITOTANE; PHENYL GROUP; UNCLASSIFIED DRUG;

ADRENAL CORTEX CARCINOMA; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG DETERMINATION; DRUG ISOLATION; DRUG MONITORING; ELUTION; HUMAN; PRIORITY JOURNAL; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY;

ADRENAL CORTEX NEOPLASMS; ANTINEOPLASTIC AGENTS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; HUMANS; MITOTANE;

EID: 79960556534 PISSN: 15700232 EISSN: 1873376X Source Type: Journal
DOI: 10.1016/j.jchromb.2011.06.001 Document Type: Article

Times cited : (15)

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