A new simple HPLC method for measuring mitotane and its two principal metabolites. Tests in animals and mitotane-treated patients

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

Volumn 837, Issue 1-2, 2006, Pages 69-75

  De Francia, Sivia ^a   Pirro, Elisa ^a   Zappia, Franco ^b   De Martino, Francesca ^a   Sprio, Andrea Elio ^a   Daffara, Fulvia ^a   Terzolo, Massimo ^a   Berruti, Alfredo ^a   Di Carlo, Francesco ^a   Ghezzo, Franco ^a  

^a UNIVERSITY OF TURIN   (Italy)

^b Bioanswers SAS   (Italy)

Author keywords

Adrenocortical carcinoma; DDA; DDE; DDT; HPLC; Mitotane

Indexed keywords

CONCENTRATION (PROCESS); FRUIT JUICES; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HYDROXYLATION; METABOLITES;

ADRENOCORTICAL CARCINOMA; DDE; DDT; HPLC; MITOTANE;

FULLERENES;

CYTOCHROME P450 ISOENZYME; DICHLORODIPHENYLACETATE; DICHLORODIPHENYLETHENE; DRUG METABOLITE; ERYTHROMYCIN; MITOTANE; UNCLASSIFIED DRUG;

ANALYTIC METHOD; ANIMAL EXPERIMENT; ARTICLE; BIOACCUMULATION; BLOOD ANALYSIS; BLOOD SAMPLING; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG DETERMINATION; DRUG HYDROXYLATION; DRUG TISSUE LEVEL; GRAPEFRUIT JUICE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; ULTRAVIOLET SPECTROSCOPY;

ANIMALS; ANTINEOPLASTIC AGENTS, HORMONAL; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; HUMANS; MALE; MITOTANE; RATS; RATS, SPRAGUE-DAWLEY; SPECTROPHOTOMETRY, ULTRAVIOLET;

ANIMALIA; CITRUS X PARADISI;

EID: 33646868387     PISSN: 15700232     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jchromb.2006.04.005     Document Type: Article

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