Should we treat mild subclinical/mild hyperthyroidism? No

European Journal of Internal Medicine

Volumn 22, Issue 4, 2011, Pages 330-333

  Vanderpump, Mark P J ^a  

^a ROYAL FREE LONDON NHS FOUNDATION TRUST   (United Kingdom)

Author keywords

Graves' disease; Non thyroidal illness; Subclinical hyperthyroidism; Toxic nodular goitre

Indexed keywords

ANTITHYROID AGENT; LEVOTHYROXINE; LIOTHYRONINE; RADIOACTIVE IODINE; THIONAMIDE DERIVATIVE; THYROID HORMONE; THYROTROPIN; THYROXINE;

ADENOMA; ALZHEIMER DISEASE; ANGINA PECTORIS; ARTICLE; COGNITIVE DEFECT; DIAGNOSTIC ACCURACY; DISEASE ASSOCIATION; DISEASE EXACERBATION; DOSE RESPONSE; DRUG FATALITY; DRUG SAFETY; EVIDENCE BASED MEDICINE; FALSE POSITIVE RESULT; FRAGILITY FRACTURE; GOLD STANDARD; GRAVES DISEASE; HEART ATRIUM FIBRILLATION; HEART PALPITATION; HORMONAL THERAPY; HORMONE SUBSTITUTION; HUMAN; HYPERTHYROIDISM; HYPOTHYROIDISM; IODINE DEFICIENCY; LIOTHYRONINE BLOOD LEVEL; NERVOUSNESS; NODULAR GOITER; OSTEOPOROSIS; PHASE 2 CLINICAL TRIAL; RECURRENT DISEASE; RISK FACTOR; SIDE EFFECT; SUBCLINICAL HYPERTHYROIDISM; SUBCLINICAL HYPETHYROIDISM; SURGICAL TECHNIQUE; THERAPY DELAY; THYROIDITIS; THYROTOXICOSIS; THYROTROPIN BLOOD LEVEL; THYROXINE BLOOD LEVEL; TOXIC GOITER; TREATMENT INDICATION;

EID: 79960554174     PISSN: 09536205     EISSN: 18790828     Source Type: Journal    
DOI: 10.1016/j.ejim.2011.03.009     Document Type: Note

References (37)

1. M.P.J. Vanderpump The epidemiology of thyroid diseases L.E. Braverman, R.D. Utiger, Werner and Ingbar's the thyroid: a fundamental and clinical text 9th edn. 2005 JB Lippincott-Raven Philadelphia 398 406
2. B. Biondi, and D.C. Cooper The clinical significance of subclinical thyroid dysfunction Endocr Rev 29 2008 76 131 (Pubitemid 351252748)
3. G.J. Canaris, N.R. Manowitz, G. Mayor, and E.C. Ridgway The Colorado thyroid disease prevalence study Arch Intern Med 160 2000 526 534 (Pubitemid 30112276)
4. 4, and thyroid antibodies in the United States population (1988 to 1994): National Health and Nutrition Examination Survey (NHANES III) J Clin Endocrinol Metab 87 2002 489 499 (Pubitemid 34158210)
5. C.T. Sawin, A. Geller, M.M. Kaplan, P. Bacharach, P.W.F. Wilson, and J.M. Hershman Low serum thyrotropin (thyroid-stimulating hormone) in older persons without hyperthyroidism Arch Intern Med 151 1991 165 168
6. A.M. Kanaya, F. Harris, S. Volpato, E.J. Pérez-Stable, T. Harris, and D. Bauer Association between thyroid dysfunction and total cholesterol level in an older biracial population. The health, aging and body composition study Arch Intern Med 162 2002 773 779 (Pubitemid 34273299)
7. J. Gussekloo, E. van Exel, A.J.M. de Craen, M. Frölich, and R.G.J. Westendorp Thyroid status, disability and cognitive function, and survival in old age JAMA 292 2004 2591 2599 (Pubitemid 39577515)
8. F. Aghini-Lombardi, L. Antonangeli, E. Martino, P. Vilti, D. Maccherri, and F. Leoli The spectrum of thyroid disorders in an iodine-deficient community: the Pescopagano survey J Clin Endocrinol Metab 84 1999 561 566 (Pubitemid 29075684)
9. P. Laurberg, I. Bulow Pedersen, N. Knudsen, L. Ovesen, and S. Andersen Environmental iodine intake affects the type of non-malignant thyroid disease Thyroid 11 2001 457 469
10. L.M. Demers, and C.A. Spencer Laboratory medicine practice guidelines: laboratory support for the diagnosis and monitoring of thyroid disease 2002 National Academy of Clinical Biochemistry URL: http://www.nacb.org/monograph/ Thyroid-index.htm
11. Association of Clinical Biochemistry, British Thyroid Association and British Thyroid Foundation UK guidelines for the use of thyroid function tests 2006 ACB and BTA London URL: http://www.british-thyroid-association.org/info- for-patients/Docs/TFT-guideline-final-version-July-2006.pdf
12. J.W. Chu, and L.M. Crapo The treatment of subclinical hypothyroidism is seldom necessary J Clin Endocrinol Metab 86 2001 4591 4599 (Pubitemid 33020490)
13. J.V. Parle, J.A. Franklyn, K.W. Cross, S.R. Jones, and M.C. Sheppard Prevalence and follow-up of abnormal thyrotrophin (TSH) concentrations in the elderly in the United Kingdom Clin Endocrinol 34 1991 77 83
14. P.W. Rosario The natural history of subclinical hyperthyroidism in elderly patients with TSH between 0.1 and 0.4 m U/L: a prospective study Clin Endocrinol 72 2010 685 688
15. T. Vadiveloo, P.T. Donnan, L. Cochrane, and G.P. Leese The thyroid epidemiology, audit, and research study (TEARS): the natural history of endogenous subclinical hyperthyroidism J Clin Endocrinol Metab 2010 10.1210/jc.2010-0854 [Epub ahead of print]
16. J. Attia, P. Margetts, and G. Guyatt Diagnosis of thyroid disease in hospitalized patients. A systematic review Arch Intern Med 159 1999 658 665 (Pubitemid 29177654)
17. P.J. Drinka, J. Amberson, S.K. Voeks, J. Schomisch, P. Schirz, and D. Christensen Low TSH levels in nursing home residents not taking thyroid hormone J Am Geriatr Soc 44 1996 573 577 (Pubitemid 26137240)
18. J.V. Parle, P. Maisonneuve, M.C. Sheppard, P. Boyle, and J.A. Franklyn Prediction of all-cause and cardiovascular mortality in elderly people from one low serum thyrotropin result: a 10-year cohort study Lancet 358 2001 861 865 (Pubitemid 32900566)
19. N. Ochs, R. Auer, D.C. Bauer, D. Nanchen, J. Gussekloo, and J. Cornuz Meta-analysis: subclinical thyroid dysfunction and the risk of coronary heart disease and mortality Ann Intern Med 148 2008 832 845 (Pubitemid 351786932)
20. C. Sawin, A. Geller, and P. Wolf Low serum thyrotropin concentrations as a risk factor for atrial fibrillation in older persons N Engl J Med 331 1994 1249 1252 (Pubitemid 24333188)
21. A.R. Cappola, L.P. Fried, and A.M. Arnold Thyroid status, cardiovascular risk and mortality in older adults JAMA 295 2006 1033 1041
22. E.N. Pearce, Q. Yang, E.J. Benjamin, J. Aragam, and R.S. Vasan Thyroid function and left ventricular structure and function in the Framingham Heart Study Thyroid 20 2010 369 373
23. M. Dörr, T. Itterman, N. Aumann, A. Obst, T. Reffelman, and M. Nauck Subclinical hyperthyroidism is not associated with progression of cardiac mass and development of left ventricular hypertrophy in middle-aged and older subjects. Results from a five-year follow-up Clin Endocrinol 2010 10.1111/j.1365-2265.2010.03882.x [Epub ahead of print]
24. D.C. Bauer, M.C. Nevitt, B. Ettinger, and K. Stone Low thyrotropin levels are not associated with bone loss in older women: a prospective study J Clin Endocrinol Metab 82 1997 2931 2936 (Pubitemid 27385651)
25. S. Cummings, M.C. Nevitt, W.S. Browner, K. Stone, K.M. Fox, and K.E. Ensrud Risk factors for hip fracture in white women N Engl J Med 332 1995 767 773
26. B. Uzzan, J. Campos, M. Cucherat, P. Nony, J.P. Boissel, and G.Y. Perret Effects on bone mass of long term treatment with thyroid hormones: a meta-analysis J Clin Endocrinol Metab 81 1996 4278 4289 (Pubitemid 26412030)
27. J. Faber, and A.M. Galloe Changes in bone mass during prolonged subclinical hyperthyroidism due to L-thyroxine treatment: a meta-analysis Eur J Endocrinol 130 1994 350 356 (Pubitemid 24135720)
28. W.M. Wiersinga Subclinical hypothyroidism and hyperthyroidism. I. Prevalence and incidence Neth J Med 46 1995 197 204
29. S. Kalmijn, K.M. Mehta, H.A. Pols, A. Hofman, H.A. Drexhage, and M.M. Breteler Subclinical hyperthyroidism and the risk of dementia. The Rotterdam study Clin Endocrinol 53 2000 733 737 (Pubitemid 32096685)
30. Al Mitchell, and S.H.S. Pearce How should we treat patients with low serum thyrotrophin concentrations? Clin Endocrinol 72 2010 292 296
31. S.H.S. Pearce Spontanoeus reporting of adverse reaction to carbimazole and propythiouracil in the United Kingdom Clin Endocrinol 61 2004 589 594
32. R. Jaeschke, G. Guyatt, H. Gerstein, C. Patterson, W. Molloy, and D. Cook Does treatment with L-thyroxine influence health status in middle-aged and older adults with subclinical hypothyroidism? J Gen Intern Med 11 1996 744 749 (Pubitemid 27009653)
33. W.M. Kong, M.H. Sheikh, P.J. Lumb, R.P. Naoumova, D.B. Freedman, and M. Crook A 6-month randomized trial of thyroxine treatment in women with mild subclinical hypothyroidism Am J Med 112 2002 348 354 (Pubitemid 34246264)
34. E. Nystrom, K. Caidahl, G. Fager, C. Wikkelso, P.A. Lundberg, and G. Lindstedt A double-blind cross-over 12-month study of L-thyroxine treatment of women with 'subclinical' hypothyroidism Clin Endocrinol 29 1988 63 75
35. S.L. Greenspan, and F.S. Greenspan The effect of thyroid hormone on skeletal integrity Ann Intern Med 130 1999 750 758 (Pubitemid 29211514)
36. J.V. Parle, J.A. Franklyn, K.W. Cross, S.R. Jones, and M.C. Sheppard Thyroxine prescription in the community: serum thyroid stimulating hormone level assays as an indicator of undertreatment or overtreatment Br J Gen Pract 43 1993 107 109 (Pubitemid 23121696)
37. M.I. Surks, E. Ortiz, G.H. Daniels, C.T. Sawin, N.F. Col, and R.H. Cobin Subclinical thyroid disease. Scientific review and guidelines for diagnosis and management JAMA 291 2004 228 238 (Pubitemid 38082818)