How should we treat patients with low serum thyrotropin concentrations?

Clinical Endocrinology

Volumn 72, Issue 3, 2010, Pages 292-296

  Mitchell, Anna L ^a,b   Pearce, Simon H S ^a,b  

^a NEWCASTLE UNIVERSITY   (United Kingdom)

^b ROYAL VICTORIA INFIRMARY   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CARBIMAZOLE; RADIOACTIVE IODINE; THYROTROPIN;

AGING; GOITER; HEART ATRIUM FIBRILLATION; HUMAN; HYPERTHYROIDISM; HYPOTHALAMUS HYPOPHYSIS SYSTEM; INTROSPECTION; MORTALITY; NOTE; OBSERVATIONAL STUDY; OSTEOPOROSIS; OUTCOME ASSESSMENT; PHYSIOLOGY; PRIORITY JOURNAL; RISK; THYROID FUNCTION; THYROTOXICOSIS; THYROTROPIN BLOOD LEVEL; VASCULAR DISEASE;

AGING; HUMANS; HYPERTHYROIDISM; THYROID GLAND; THYROTROPIN;

EID: 76649119835     PISSN: 03000664     EISSN: 13652265     Source Type: Journal    
DOI: 10.1111/j.1365-2265.2009.03694.x     Document Type: Note

References (29)

1. Hollowell, J.G., Staehling, N.W., Flanders, W.D. et al. (2002) Serum TSH, T4 and thyroid antibodies in the United States population (1988 to 1994): National Health and Nutrition Examination Survey (NHANES III). Journal of Clinical Endocrinology and Metabolism, 87, 489 499.
2. Mariotti, S., Franceschi, C., Cossarizza, A. et al. (1995) The aging thyroid. Endocrine Reviews, 16, 686 715.
3. Sawin, C.T., Geller, A., Kaplan, M.M. et al. (1991) Low serum thyrotropin (thyroid-stimulating hormone) in older persons without thyrotoxicosis. Archives of Internal Medicine, 151, 165 168.
4. Erfuth, E.M., Norden, N.E., Hedner, P. et al. (1984) Normal reference interval for thyrotropin response to thyroliberin: dependence on age, sex, free thyroxin index, and basal concentrations of thyrotropin. Clinical Chemistry, 30, 196 199.
5. Harman, S.M., Wehmann, R.E. Blackman, M.R. (1984) Pituitary-thyroid hormone economy in healthy aging men: basal indices of thyroid function and thyrotropin responses to constant infusions of thyrotropin releasing hormone. Journal of Clinical Endocrinology and Metabolism, 58, 320 326.
6. Mariotti, S., Barbesino, G., Caturegli, P. et al. (1993) Complex alteration of thyroid function in healthy centenarians. Journal of Clinical Endocrinology and Metabolism, 77, 1130 1134.
7. Jacques, C., Schlienger, J.L., Kissel, C. et al. (1987) TRH-induced TSH and prolactin responses in the elderly. Age and Ageing, 16, 181 188.
8. Lewis, G.F., Alessi, C.A., Imperial, J.G. et al. (1991) Low serum free thyroxine index in ambulating elderly is due to a resetting of the threshold of thyrotropin feedback suppression. Clinics in Endocrinology and Metabolism, 73, 843 849.
9. Gregerman, R.I., Gaffney, G.W., Shock, N.W. et al. (1962) Thyroxine turnover in euthyroid man with special reference to changes with age. Journal of Clinical Investigation, 41, 2065 2074.
10. Parle, J., Maisonneuve, P., Sheppard, M. et al. (2001) A single low thyrotrophin (TSH) concentration predicts increased all-cause and cardiovascular mortality in older persons in the community. A 10 year cohort study. Lancet, 358, 861 865.
11. Gussekloo, J., van Exel, E., de Craen, A.J.M. et al. (2004) Thyroid status, disability and cognitive function and survival in old age. Journal of the American Medical Association, 292, 2591 2599.
12. Sawin, C.T., Geller, A., Wolf, P.A. et al. (1994) Low serum thyrotropin concentrations as a risk factor for atrial fibrillation in older persons. New England Journal of Medicine, 331, 1249 1252.
13. Cappola, A.R., Fried, L.P., Arnold, A.M. et al. (2006) Thyroid status, cardiovascular risk and mortality in older adults. Journal of the American Medical Association, 295, 1033 1041.
14. Shapiro, L.E., Sievert, R., Ong, L. et al. (1997) Minimal cardiac effects in asymptomatic athyreotic patients chronically treated with thyrotropin-suppressive doses of L-thyroxine. Journal of Clinical Endocrinology and Metabolism, 82, 2592 2595.
15. Shargorodsky, M., Serov, S., Gavish, D. et al. (2006) Long-term thyrotropin-suppressive therapy with levothyroxine impairs small and large artery elasticity and increases left ventricular mass in patients with thyroid carcinoma. Thyroid, 16, 381 386.
16. Biondi, B., Fazio, S., Palmieri, E.A. et al. (1999) Effects of chronic subclinical hyperthyroidism from levothyroxine on cardiac morphology and function. Cardiologia, 44, 443 449.
17. Smit, J.W., Eustatia-Rutten, C.F., Corssmit, E.P. et al. (2005) Reversible diastolic dysfunction after long-term exogenous subclinical hyperthyroidism: a randomized, placebo-controlled study. Journal of Clinical Endocrinology and Metabolism, 90, 6041 6047.
18. Biondi, B., Palmieri, E.A., Lombardi, G. et al. (2002) Effects of subclinical thyroid dysfunction on the heart. Annals of Internal Medicine, 137, 904 914.
19. Bauer, D.C., Ettinger, B., Nevitt, M.C. et al. (2001) Risk for fracture in women with low serum levels of thyroid stimulating hormone. Annals of Internal Medicine, 134, 561 568.
20. Brennan, M.D., Powell, C., Kaufman, K.R. et al. (2006) The impact of overt and subclinical hyperthyroidism on skeletal muscle. Thyroid, 16, 375 380.
21. Kalmijn, S., Mehta, K.M., Pols, H.A.P. et al. (2000) Subclinical hyperthyroidism and the risk of dementia. The Rotterdam Study. Clinical Endocrinology, 53, 733 737.
22. Döbert, N., Hamscho, N., Menzel, C. et al. (2003) Subclinical hyperthyroidism in dementia and correlation of the metabolic index in FDG-PET. Acta Medica Austriaca, 30, 130 133.
23. Roberts, L.M., Pattison, H., Roalfe, A. et al. (2006) Is subclinical thyroid dysfunction in the elderly associated with depression or cognitive dysfunction? Annals of Internal Medicine, 145, 573 581.
24. Parle, J.V., Franklyn, J.A., Cross, K.W. et al. (1991) Prevalence and follow-up of abnormal thyrotrophin (TSH) concentrations in the elderly in the United Kingdom. Clinical Endocrinology, 34, 77 83.
25. Surks, M.I., Ortiz, E., Daniels, G.H. et al. (2004) Subclinical thyroid disease: scientific review and guidelines for diagnosis and management. Journal of the American Medical Association, 291, 228 238.
26. Gharib, H., Tuttle, M., Baskin, H.J. et al. (2005) Subclinical thyroid dysfunction: a joint statement on management from the American Association of Clinical Endocrinologists, the American Thyroid Association and the Endocrine Society. Journal of Clinical Endocrinology and Metabolism, 90, 581 585. (Pubitemid 40116712)
27. Parle, J., Franklyn, J.A., Cross, K. et al. (1991) Prevalence and follow up of abnormal thyrotropin concentrations in the elderly in the United Kingdom. Clinical Endocrinology, 34, 77 83.
28. Bartalena, L., Bogazzi, F. Martino, E. (1996) Adverse effects of thyroid hormone preparations and antithyroid drugs. Drug Safety, 15, 53 63.
29. Pearce, S.H.S. (2004) Spontaneous reporting of adverse reaction to carbimazole and propylthiouracil in the United Kingdom. Clinical Endocrinology, 61, 589 594.