Intracoronary autologous mononucleated bone marrow cell infusion for acute myocardial infarction: Results of the randomized multicenter BONAMI trial

European Heart Journal

Volumn 32, Issue 14, 2011, Pages 1748-1757

  Roncalli, Jérôme ^a   Mouquet, Frédéric ^b   Piot, Christophe ^c   Trochu, Jean Noel ^d   Le Corvoisier, Philippe ^e   Neuder, Yannick ^f   Le Tourneau, Thierry ^b,d   Agostini, Denis ^g   Gaxotte, Virginia ^h   Sportouch, Catherine ^c   Galinier, Michel ^a   Crochet, Dominique ^d   Teiger, Emmanuel ^e   Richard, Marie Jeanne ^f   Polge, Anne Sophie ^b   Beregi, Jean Paul ^h   Manrique, Alain ^g   Carrie, Didier ^a   Susen, Sophie ^h   Klein, Bernard ^c   Parini, Angelo ^a   Lamirault, Guillaume ^d   Croisille, Pierre ⁱ   Rouard, Hèléne ^j   Bourin, Philippe ^k   Nguyen, Jean Michel ^l   Delasalle, Béatrice ^d   Vanzetto, Gérald ^f   Van Belle, Eric ^b   Lemarchand, Patricia ^d   more..

^a TOULOUSE UNIVERSITY HOSPITAL   (France)

^b LILLE UNIVERSITY HOSPITAL   (France)

^c MONTPELLIER UNIVERSITY HOSPITAL   (France)

^d L INSTITUT DU THORAX   (France)

^e HENRI MONDOR HOSPITAL   (France)

^f GRENOBLE UNIVERSITY HOSPITAL   (France)

^g CAEN UNIVERSITY HOSPITAL   (France)

^h UNIV LILLE   (France)

ⁱ UNIVERSITÉ DE LYON   (France)

^j ETABLISSEMENT FRANÇAIS DU SANG   (France)

^k UMR 5563 OMP CNRS   (France)

^l NANTES UNIVERSITY HOSPITAL   (France)

more..

Author keywords

Cells; Myocardial infarction; Smoking

Indexed keywords

RADIOISOTOPE;

ACUTE HEART INFARCTION; ADULT; AGED; ANGIOGRAPHY; ARTICLE; AUTOLOGOUS MONONUCLEATED BONE MARROW CELL INFUSION; BLOOD VESSEL OCCLUSION; CELL THERAPY; CONTROLLED STUDY; DIABETES MELLITUS; FEMALE; HEART LEFT VENTRICLE EJECTION FRACTION; HEART MUSCLE; HUMAN; HYPERLIPIDEMIA; HYPERTENSION; INTRACORONARY INFUSION; MAJOR CLINICAL STUDY; MALE; MULTICENTER STUDY; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; RISK FACTOR; SMOKING;

ADOLESCENT; ADULT; AGED; BONE MARROW TRANSPLANTATION; CORONARY ANGIOGRAPHY; CORONARY VESSELS; FEMALE; HUMANS; LEUKOCYTES, MONONUCLEAR; MAGNETIC RESONANCE ANGIOGRAPHY; MALE; MIDDLE AGED; MYOCARDIAL INFARCTION; STROKE VOLUME; TOMOGRAPHY, EMISSION-COMPUTED, SINGLE-PHOTON; TRANSPLANTATION, AUTOLOGOUS; TREATMENT OUTCOME; VENTRICULAR DYSFUNCTION, LEFT; YOUNG ADULT;

EID: 79960541758     PISSN: 0195668X     EISSN: 15229645     Source Type: Journal    
DOI: 10.1093/eurheartj/ehq455     Document Type: Article

References (21)

1. Strauer BE, Brehm M, Zeus T, Kostering M, Hernandez A, Sorg RV, Kogler G, Wernet P. Repair of infarcted myocardium by autologous intracoronary mononuclear bone marrow cell transplantation in humans. Circulation 2002;106: 1913-1918. (Pubitemid 35176294)
2. Schachinger V, Erbs S, Elsasser A, Haberbosch W, Hambrecht R, Holschermann H, Yu J, Corti R, Mathey DG, Hamm CW, Suselbeck T, Assmus B, Tonn T, Dimmeler S, Zeiher AM. Intracoronary bone marrow-derived progenitor cells in acute myocardial infarction. N Engl J Med 2006;355: 1210-1221. (Pubitemid 44427445)
3. Wollert KC, Meyer GP, Lotz J, Ringes-Lichtenberg S, Lippolt P, Breidenbach C, Fichtner S, Korte T, Hornig B, Messinger D, Arseniev L, Hertenstein B, Ganser A, Drexler H. Intracoronary autologous bone-marrow cell transfer after myocardial infarction: the BOOST randomised controlled clinical trial. Lancet 2004;364:141-148. (Pubitemid 38891685)
4. Meyer GP, Wollert KC, Lotz J, Steffens J, Lippolt P, Fichtner S, Hecker H, Schaefer A, Arseniev L, Hertenstein B, Ganser A, Drexler H. Intracoronary bone marrow cell transfer after myocardial infarction: eighteen months' follow-up data from the randomized, controlled BOOST (BOne marrOw transfer to enhance ST-elevation infarct regeneration) trial. Circulation 2006;113:1287-1294. (Pubitemid 43739450)
5. Janssens S, Dubois C, Bogaert J, Theunissen K, Deroose C, Desmet W, Kalantzi M, Herbots L, Sinnaeve P, Dens J, Maertens J, Rademakers F, Dymarkowski S, Gheysens O, Van Cleemput J, Bormans G, Nuyts J, Belmans A, Mortelmans L, Boogaerts M, Van de Werf F. Autologous bone marrow-derived stem-cell transfer in patients with ST-segment elevation myocardial infarction: double-blind, randomised controlled trial. Lancet 2006;367:113-121. (Pubitemid 43077127)
6. Lunde K, Solheim S, Aakhus S, Arnesen H, Abdelnoor M, Egeland T, Endresen K, Ilebekk A, Mangschau A, Fjeld JG, Smith HJ, Taraldsrud E, Grogaard HK, Bjornerheim R, Brekke M, Muller C, Hopp E, Ragnarsson A, Brinchmann JE, Forfang K. Intracoronary injection of mononuclear bone marrow cells in acute myocardial infarction. N Engl J Med 2006;355:1199-1209. (Pubitemid 44427444)
7. + cells and non-selected mononuclear cells in patients with acute STEMI and reduced left ventricular ejection fraction: results of randomized, multicentre Myocardial Regeneration by Intracoronary Infusion of Selected Population of Stem Cells in Acute Myocardial Infarction (REGENT) Trial. Eur Heart J 2009;30:1313-1321.
8. Martin-Rendon E, Brunskill SJ, Hyde CJ, Stanworth SJ, Mathur A, Watt SM. Autologous bone marrow stem cells to treat acute myocardial infarction: a systematic review. Eur Heart J 2008;29:1807-1818.
9. Vasa M, Fichtlscherer S, Aicher A, Adler K, Urbich C, Martin H, Zeiher AM, Dimmeler S. Number and migratory activity of circulating endothelial progenitor cells inversely correlate with risk factors for coronary artery disease. Circ Res 2001;89:E1-E7.
10. Senior R, Kaul S, Lahiri A. Myocardial viability on echocardiography predicts longterm survival after revascularization in patients with ischemic congestive heart failure. J Am Coll Cardiol 1999;33:1848-1854.
11. Dimmeler S, Zeiher AM. Vascular repair by circulating endothelial progenitor cells: the missing link in atherosclerosis? J Mol Med 2004;82:671-677. (Pubitemid 39468491)
12. Dill T, Schachinger V, Rolf A, Mollmann S, Thiele H, Tillmanns H, Assmus B, Dimmeler S, Zeiher AM, Hamm C. Intracoronary administration of bone marrowderived progenitor cells improves left ventricular function in patients at risk for adverse remodeling after acute ST-segment elevation myocardial infarction: results of the Reinfusion of Enriched Progenitor cells And Infarct Remodeling in Acute Myocardial Infarction study (REPAIR-AMI) cardiac magnetic resonance imaging substudy. Am Heart J 2009;157:541-547.
13. Shintani S, Murohara T, Ikeda H, Ueno T, Sasaki K, Duan J, Imaizumi T. Augmentation of postnatal neovascularization with autologous bone marrow transplantation. Circulation 2001;103:897-903. (Pubitemid 32163891)
14. Beygui F, Le Feuvre C, Helft G, Maunoury C, Metzger JP. Myocardial viability, coronary flow reserve, and in-hospital predictors of late recovery of contractility following successful primary stenting for acute myocardial infarction. Heart 2003;89: 179-183. (Pubitemid 36115103)
15. Panza JA, Dilsizian V, Laurienzo JM, Curiel RV, Katsiyiannis PT. Relation between thallium uptake and contractile response to dobutamine. Implications regarding myocardial viability in patients with chronic coronary artery disease and left ventricular dysfunction. Circulation 1995;91:990-998.
16. Erbs S, Linke A, Schachinger V, Assmus B, Thiele H, Diederich KW, Hoffmann C, Dimmeler S, Tonn T, Hambrecht R, Zeiher AM, Schuler G. Restoration of microvascular function in the infarct-related artery by intracoronary transplantation of bone marrow progenitor cells in patients with acute myocardial infarction: the Doppler Substudy of the Reinfusion of Enriched Progenitor Cells and Infarct Remodeling in Acute Myocardial Infarction (REPAIR-AMI) trial. Circulation 2007; 116:366-374. (Pubitemid 47196542)
17. Wu KC, Zerhouni EA, Judd RM, Lugo-Olivieri CH, Barouch LA, Schulman SP, Blumenthal RS, Lima JA. Prognostic significance of microvascular obstruction by magnetic resonance imaging in patients with acute myocardial infarction. Circulation 1998;97:765-772. (Pubitemid 28135339)
18. Hombach V, Grebe O, Merkle N, Waldenmaier S, Hoher M, Kochs M, Wohrle J, Kestler HA. Sequelae of acute myocardial infarction regarding cardiac structure and function and their prognostic significance as assessed by magnetic resonance imaging. Eur Heart J 2005;26:549-557. (Pubitemid 40461096)
19. Dimmeler S, Zeiher AM. Reactive oxygen species and vascular cell apoptosis in response to angiotensin II and pro-atherosclerotic factors. Regul Pept 2000;90: 19-25. (Pubitemid 30331005)
20. Li AE, Ito H, Rovira II, Kim KS, Takeda K, Yu ZY, Ferrans VJ, Finkel T. A role for reactive oxygen species in endothelial cell anoikis. Circ Res 1999;85:304-310. (Pubitemid 29398862)
21. Staat P, Rioufol G, Piot C, Cottin Y, Cung TT, L'Huillier I, Aupetit JF, Bonnefoy E, Finet G, Andre-Fouet X, Ovize M. Postconditioning the human heart. Circulation 2005;112:2143-2148. (Pubitemid 41475808)