Pediatric Urinary Tract Infections

Emergency Medicine Clinics of North America

Volumn 29, Issue 3, 2011, Pages 637-653

  Bhat, Rahul G ^a,b   Katy, Tamara A ^a   Place, Frederick C ^c  

^a GEORGETOWN UNIVERSITY HOSPITAL   (United States)

^b WASHINGTON HOSPITAL CENTER   (United States)

^c VIRGINIA COMMONWEALTH UNIVERSITY   (United States)

Author keywords

Escherichia coli; Pediatric; Urinalysis; Urinary tract infections; Urine culture

Indexed keywords

ASYMPTOMATIC BACTERIURIA; BACTERIUM DETECTION; CHILD BEHAVIOR; CIRCUMCISION; CLINICAL FEATURE; CULTURE TECHNIQUE; DIAGNOSTIC TEST; DISEASE COURSE; EMERGENCY CARE; FOLLOW UP; HOST SUSCEPTIBILITY; HUMAN; INFECTION RISK; INTERMETHOD COMPARISON; LABORATORY TEST; MEDICAL HISTORY; MICROSCOPY; PATHOGENESIS; PEDIATRICS; PHYSICAL EXAMINATION; PRIORITY JOURNAL; RACE DIFFERENCE; REVIEW; RISK FACTOR; SEX DIFFERENCE; SUPRAPUBIC ASPIRATION; SYSTEMIC DISEASE; TREATMENT PLANNING; URETHRAL CATHETERIZATION; URINARY TRACT INFECTION; URINE CULTURE;

EID: 79960529949     PISSN: 07338627     EISSN: 07338627     Source Type: Journal    
DOI: 10.1016/j.emc.2011.04.004     Document Type: Review

References (116)

1. Jacobson S.H., Eriksson C.G., Lins L., et al. Development of hypertension and uraemia after pyelonephritis in childhood: 27 year follow up. BMJ 1989, 299:703-706.
2. Zorc J.J., Kiddoo D.A., Shaw K.N. Diagnosis and management of pediatric urinary tract infections. Clin Microbiol Rev 2005, 18:417-422.
3. Sedberry-Ross S., Pohl H.G. Urinary tract infections in children. Curr Urol Rep 2008, 9:165-171.
4. Zorc J.J., Levine D.A., Platt S.L., et al. Clinical and demographic factors associated with urinary tract infection in young febrile infants. Pediatrics 2005, 116:644-648.
5. Newman T.B., Bernzweig J.A., Takayama J.I., et al. Urine testing and urinary tract infections in febrile infants seen in office settings. Arch Pediatr Adolesc Med 2002, 156:44-54.
6. Hoberman A., Wald E.R., Hickey R.W., et al. Oral versus initial intravenous therapy for urinary tract infections in young febrile children. Pediatrics 1999, 104:79-86.
7. Doganis D., Siafas K., Mavrikou M., et al. Does early treatment of urinary tract infection prevent renal damage. Pediatrics 2007, 120:e922.
8. Paschke A.A., Zaoutis T., Conway P.H., et al. Previous antimicrobial exposure is associated with drug-resistant urinary tract infections in children. Pediatrics 2010, 125:664-672.
9. Ronald A. The etiology of urinary tract infection: traditional and emerging pathogens. Am J Med 2002, 113(Suppl 1A):14S.
10. Sobel J.D., Vazquez J.A. Fungal Infections of the urinary tract. World J Urol 1999, 17:410.
11. Smitherman H.F., Caviness C., Macias C.G. Retrospective review of serious bacterial infections in infants who are 0 to 36 months of age and have influenza A infection. Pediatrics 2005, 115:710-718.
12. Chang S.L., Shortliffe L.D. Pediatric urinary tract infections. Pediatr Clin North Am 2006, 53:379-400.
13. Kuo H., Mak R.H. Pathogenesis of urinary tract infection: an update. Curr Opin Pediatr 2006, 18:148-252.
14. Bachur R., Harper M.B. Reliability of the urinalysis for predicting urinary tract infections in young febrile children. Arch Pediatr Adolesc Med 2001, 155:60-65.
15. Conway P.H., Cnaan A., Zaoutis T., et al. Recurrent urinary tract infections in children: risk factors and association with prophylactic antimicrobials. JAMA 2007, 298:179-186.
16. Shaw K.N., Gorelick M., McGowan K.L., et al. Prevalence of urinary tract infection in febrile young children in the emergency department. Pediatrics 1998, 102:e16-e21.
17. Sahsi R.S., Carpenter C.R. Does this child have a urinary tract infection?. Ann Emerg Med 2009, 53:680-684.
18. Crain E.F., Gershel J.C. Urinary tract infections in febrile infants younger than 8 weeks of age. Pediatrics 1990, 86:363-367.
19. Hoberman A., Chao H., Keller D.M., et al. Prevalence of urinary tract infection in febrile infants. J Pediatr 1993, 123:17-23.
20. Practice parameter: the diagnosis, treatment, and evaluation of the initial urinary tract infection in febrile infants and young children American Academy of Pediatrics; Committee on Quality Improvement, Subcommittee on Urinary Tract Infection. Pediatrics 1999, 103:843-852.
21. Shaikh N., Morone N.E., Bost J.E., et al. Prevalence of urinary tract infection in childhood: a meta-analysis. Pediatr Infect Dis J 2008, 27:302.
22. Baraff L.J. Management of fever without source in infants and children. Ann Emerg Med 2000, 36:602-614.
23. Wiswell T.E., Smith F.R., Bass J.W. Decreased incidence of urinary tract infections in circumcised male infants. Pediatrics 1985, 75:901-903.
24. Schoen E.J., Colby C.J., Ray G.T. Newborn circumcision decreases incidence and costs of urinary tract infections during the first year of life. Pediatrics 2000, 105:789-793.
25. Fusell E.N., Kaack M.B., Cherry R., et al. Adherence of bacteria to human foreskins. J Urol 1988, 140:997-1001.
26. Hiraoka M., Tsukahara H., Ohshima Y., et al. Meatus tightly covered by the prepuce is associated with urinary infection. Pediatr Int 2002, 44:658.
27. Gorelick M.H., Shaw K.N. Clinical decision rule to identify febrile young girls at risk for urinary tract infection. Arch Pediatr Adolesc Med 2000, 154:386-390.
28. Chen L., Baker M.D. Racial and ethnic differences in the rates of urinary tract infections in febrile infants in the emergency department. Pediatr Emerg Care 2006, 22:485.
29. Persad S., Watermeyer S., Griffiths A., et al. Association between urinary tract infection and postmicturition wiping habit. Acta Obstet Gynecol Scand 2006, 85(11):1395-1396.
30. Wan J., Kaplinsky R., Greenfield S. Toilet habits of children evaluated for urinary tract infection. J Urol 1995, 154:797.
31. Naseer S.R., Steinhardt G.F. New renal scars in children with urinary tract infections, vesicoureteral reflux and voiding dysfunction: a prospective evaluation. J Urol 1997, 158:566.
32. Snodgrass W. Relationship of voiding dysfunction to urinary tract infection and vesicoureteral reflux in children. Urology 1991, 38:341.
33. Shaikh N., Hoberman A., Wise B., et al. Dysfunctional elimination syndrome: is it related to urinary tract infection or vesicoureteral reflux diagnosed early in life?. Pediatrics 2003, 112:1134-1137.
34. Blethyn A., Jones K., Newcombe R., et al. Radiological assessment of constipation. Arch Dis Child 1995, 73:532-533.
35. Loening-Baucke V. Urinary incontinence and urinary tract infection and their resolution with treatment of chronic constipation of childhood. Pediatrics 1997, 100:228-232.
36. Lim R. Vesicoureteral reflux and urinary tract infection: evolving practices and current controversies in pediatric imaging. AJR Am J Roentgenol 2009, 109:1197-1208.
37. Garin E.H., Campos A., Homsy Y. Primary vesicoureteral reflux: review of current concepts. Pediatr Nephrol 1998, 12:249.
38. Honkinen O., Jahnukainen T., Mertsola J., et al. Bacteremic urinary tract infection in children. Pediatr Infect Dis J 2000, 19(7):630-634.
39. Garcia F.J., Nager A.L. Jaundice as an early diagnostic sign of urinary tract infection in infancy. Pediatrics 2002, 109(5):845-851.
40. National Institute for Health and Clinical Excellence Urinary tract infection in children: diagnosis, treatment and long-term management 2007, National Institute of health and Clinical Excellence, London, p. 1-136.
41. Dore-Bergeron M., Gauthier M., Chevalier I., et al. Urinary tract infections in 1- to 3-month-old infects: ambulatory treatment with intravenous antibiotics. Pediatrics 2009, 124:16-22.
42. Schroeder A.R., Newman T.B., Wasserman R.C., et al. Choice of urine collection methods for the diagnosis of urinary tract infection in young, febrile infants. Arch Pediatr Adolesc Med 2005, 159:915-922.
43. Shaikh N., Morone N.E., Lopez J., et al. Does this child have a urinary tract infection?. JAMA 2007, 298:2895-2904.
44. Krief W.I., Levine D.A., Platt S.L., et al. Influenza virus infection and the risk of serious bacterial infections in young febrile infants. Pediatrics 2009, 124:30-39.
45. Levine D.A., Platt S.L., Dayan P.S., et al. Risk of serious bacterial infection in young febrile infants with respiratory syncytial virus infections. Pediatrics 2004, 113:1728-1734.
46. Huppert J.S., Biro F.M., Mehrabi J., et al. Urinary tract infection and Chlamydia infection in adolescent females. J Pediatr Adolesc Gynecol 2003, 16:133-137.
47. Pierce A.M., Hart C.A. Vulvovaginitis: causes and management. Arch Dis Child 1992, 67:509-512.
48. Fernandes E.T., Dekermacher S., Sabadin M.A., et al. Urethral prolapse in children. Urology 1993, 41:240-242.
49. Pyrles C.V., Steg N.L. Specimens of urine obtained from young girls by catheter versus voiding: a comparative study of bacterial cultures, gram stains, and bacterial counts in paired specimens. Pediatrics 1959, 23:441-452.
50. Pryles C.V. The diagnosis of urinary tract infection. Pediatrics 1960, 26:441-451.
51. Fernandez-Menendez J.M., Malaga S., Matesanz J.L., et al. Risk factors in the development of early technetium-99m- dimercaptosuccinic acid renal scintigraphy lesions during first urinary tract infection in children. Acta Paediatr 2003, 92:21-26.
52. Gorelick M.H., Shaw K.N. Screening tests for urinary tract infection in children: a meta-analysis. Pediatrics 1999, 104:e54.
53. Israni A.K., Kasiske BL. Laboratory assessment of kidney disease: clearance, urinalysis and kidney biopsy. Brenner & Rector's the kidney 2007, 736-737. Saunders Elsevier, Philadelphia. 8th edition. B.M. Brenner (Ed.).
54. Williams G.J., Macaskill P., Chan S.F., et al. Absolute and relative accuracy of rapid urine tests for urinary tract infection in children: a meta-analysis. Lancet Infect Dis 2010, 10:240-250.
55. American College of Emergency Medicine Clinical policy for children younger than 3 years presenting to the ED with fever. Ann Emerg Med 2003, 42:530-545.
56. Lam C.N., Bremner A.D., Maxwell J.D., et al. Pyuria and bacteriuria. Arch Dis Child 1967, 42:275-280.
57. Hoberman A., Wald E.R., Reynolds E.A., et al. Pyuria and bacteriuria in urine specimens obtained by catheter from young children with fever. J Pediatr 1994, 124:513-519.
58. Jaskiewicz J.A., McCarthy C.A., Richardson A.C., et al. Febrile infants at low risk for serious bacterial infection: an appraisal of the Rochester criteria and implications for management. Pediatrics 1994, 94:390-396.
59. Baker M.D., Bell L.M., Avner J.R. Outpatient management without antibiotics of fever in selected infants. N Engl J Med 1993, 329:1437-1441.
60. Baskin M.N., O'Rourke E.J., Fleisher G.R. Outpatient treatment of febrile infants 28-89 days of age with intramuscular administration of ceftriaxone. J Pediatr 1992, 120:22-27.
61. Baraff L.J., Schriger D.L., Bass J.W., et al. Practice guideline for the management of infants and children 0 to 36 months of age with fever without source. Pediatrics 1993, 92:1-12.
62. Hoberman A., WAld E.R. Urinary tract infections in young febrile children. Pediatr Infect Dis J 1997, 16:11-17.
63. Huicho L., Campos-Sanchez M., Alamo C. Meta-analysis of urine screening tests for determining the risk of urinary tract infection in children. Pediatr Infect Dis J 2002, 21:1-11.
64. Price E., Pallett A., Gilbert R.D., et al. Microbiological aspects of the UK National Institute for Health and Clinical Excellence (NICE) guidance on urinary tract infection in children. J Antimicrob Chemother 2010, 65:836-841.
65. Helmholz H.F., Milleken F. The bacteriology of normal infants' urine. Am J Dis Child 1922, 23:309.
66. Kass E.H. Bacteriuria and the diagnosis of infections of the urinary tract. Arch Intern Med 1957, 100:709-713.
67. Vaillancourt S., McGillivray D., Zhang X., et al. To clean or not to clean: effect on contamination rates in midstream urine collections in toilet-trained children. Pediatrics 2007, 119:e1288-e1291.
68. Coulthard M.G., Kalra M., Lambert H.J., et al. Redefining urinary tract infections by bacterial colony counts. Pediatrics 2010, 125:335-341.
69. Wald E.R., DeMuri G.P. Imaging and antimicrobial prophylaxis following the diagnosis of urinary tract infection in children. Pediatr Infect Dis J 2008, 27:553-554.
70. Hoberman A., Wald E.R., Penchansky L., et al. Enhanced urinalysis as a screening test for urinary tract infection. Pediatrics 1993, 125:1196-1199.
71. Hoberman A., Charron M., Hickey R.W., et al. Imaging studies after a first febrile urinary tract infection in young children. N Engl J Med 2003, 348:195-202.
72. Sobel J.D., Kaye D. Urinary tract infections. Bennett's principles and practice of infectious diseases 2009, 957-985. Churchill Livingstone Elsevier, Philadelphia. 7th edition. G.L. Mandell, R.G. Douglas (Eds.).
73. Wettergren B., Jodal U., Jonasson G. Epidemiology of bacteriuria during the first year of life. Acta Paediatr Scand 1985, 74:925-933.
74. Abbott G.D. Neonatal bacteriuria: a prospective study in 1,460 infants. Br Med J 1972, 1:267-269.
75. Al-Orifi F., McGillivray D., Tange S., et al. Urine culture from bag specimens in young children: are the risks too high?. J Pediatr 2000, 137:221-226.
76. Pyrles C.V. Percutaneous bladder aspiration and other methods of urine collection for bacteriologic study. Pediatrics 1965, 36:128-131.
77. Nelson J.D., Peters P.C. Suprapubic aspiration of urine in premature and term infants. Pediatrics 1965, 36:132-134.
78. Newman C.G., O'Neill P., Parker A. Pyruria in infancy, and the role of suprapubic aspiration of urine in diagnosis of infection of urinary tract. Br Med J 1967, 2(5547):277-279.
79. Pryles C.V., Atkin M.D., Morse T.S., et al. Comparative bacteriologic study of urine obtained from children by percutaneous suprapubic aspiration of the bladder and by catheter. Pediatrics 1959, 24:983-991.
80. Schlager T.A., Dunn M.L., Dudley S.M., et al. Bacterial contamination rate of urine collected in a urine bag from healthy non-toilet-trained male infants. J Pediatr 1990, 116:738-739.
81. Quigley R. Diagnosis or urinary tract infections in children. Curr Opin Pediatr 2009, 21:194-198.
82. Pollack C.V., Pollack E.S., Andrew M.E. Suprapubic bladder aspiration versus uretheral catheterization in ill infants: success, efficiency, and complications rates. Ann Emerg Med 1994, 23:225-230.
83. Kozer E., Rosenbloom E., Goldman D., et al. Pain in infants who are younger than 2 months during suprapubic aspiration and transurethral bladder catheterization: a randomized, controlled study. Pediatrics 2006, 118:e51.
84. El-Naggar W., Yiu A., Mohamed A., et al. Comparison of pain during two methods of urine collection in preterm infants. Pediatrics 2010, 125:1224-1229.
85. Buys H., Pead L., Hallett R., et al. Suprapubic aspiration under ultrasound guidance in children with fever of undiagnosed cause. BMJ 1994, 308:690.
86. Munir V., Barnett P., South M. Does the use of volumetric bladder ultrasound improve the success rate of suprapubic aspiration of urine?. Pediatr Emerg Care 2002, 18:346-349.
87. Chu R.W., Wong Y.C., Luk S.H., et al. Comparing suprapubic urine aspiration under real-time ultrasound guidance with conventional blind aspiration. Acta Paediatr 2002, 91(5):512-516.
88. Gerard L.L., Cooper C.S., Duethman K.S., et al. Effectiveness of lidocaine lubricant for discomfort during pediatric urethral catheterization. J Urol 2003, 170:564-567.
89. Vaughan M., Paton E.A., Bush A., et al. Does lidocaine gel alleviate the pain of bladder catheterization in young children? A randomized, controlled trial. Pediatrics 2005, 116(4):917-920.
90. Mularoni P.P., Cohen L.L., DeGuzman M. A randomized clinical trial of lidocaine gel for reducing infant distress during urethral catheterization. Pediatr Emerg Care 2009, 25(7):439-443.
91. Milling T.J., Van Amerongen R., Melville L., et al. Use of ultrasonography to identify infants for whom urinary catheterization will be unsuccessful because of insufficient urine volume: validation of the urinary bladder index. Ann Emerg Med 2005, 45(5):510-513.
92. Chen L., Hsiao A.L., Moore C.L., et al. Utility of bedside bladder ultrasound before urethral catheterization in young children. Pediatrics 2005, 115(1):108-111.
93. Lohr J.A., Donowitz L.G., Dudley S.M. Bacterial contamination rates in voided urine collections in girls. J Pediatr 1989, 114:91-93.
94. Lohr J.A., Donowitz L.G., Dudley S.M. Bacterial contamination rates for non-clean-catch and clean-catch midstream urine collections in boys. J Pediatr 1986, 109:659-660.
95. Saez-Llorens X., Umana M.A., Odio C.M., et al. Bacterial contamination rates for non-clean catch and clean catch midstream urine collections in uncircumcised boys. J Pediatr 1989, 114:93-94.
96. Ramage I., Chapman J.P., Hollman A.S., et al. Accuracy of clean-catch urine collection in infancy. J Pediatr 1999, 135:765-767.
97. Benador N., Siegrist C., Gendrel D., et al. Procalcitonin is a marker of severity of renal lesion in pyelonephritis. Pediatrics 1998, 102:1422-1425.
98. Pecile P., Miorin E., Romanello C., et al. Procalcitonin: a marker of severità of acute pyelonephritis among children. Pediatrics 2004, 114:e249-e254.
99. Garin E.H., Olavarria F., Araya C., et al. Diagnostic significance of clinical and laboratory findings to localize site of urinary infection. Pediatr Nephrol 2007, 22:1002-1006.
100. Biggi A., Dardanelli L., Pomero G., et al. Acute renal cortical scintigraphy in children with a first urinary tract infection. Pediatr Nephrol 2001, 16:733-738.
101. Bauer R., Kogan B.A. New developments in the diagnosis and management of pediatric UTIs. Urol Clin North Am 2008, 35:47-58.
102. Hellerstein S. Acute urinary tract infection: evaluation and treatment. Curr Opin Pediatr 2006, 18:132-138.
103. Bacchur R., Caputo G.L. Bacteremia and meningitis among infants with urinary tract infections. Pediatr Emerg Care 1995, 11:280-284.
104. Pitetti R.D., Choi S. Utility of blood cultures in febrile children with UTI. Am J Emerg Med 2002, 20:271-274.
105. Goldman R.N., Matlow A., Linett L. What is the risk of bacterial meningitis in infants who present to the emergency department with fever and pyuria?. CJEM 2003, 5(6):393-399.
106. Matoo T.K. Are prophylactic antibiotics indicated after a urinary tract infection?. Curr Opin Pediatr 2009, 21:203-206.
107. Baker P.C., Nelson D.S., Schunk J.E. The addition of ceftriaxone to oral therapy does not improve outcome in febrile children with urinary tract infections. Arch Pediatr Adolesc Med 2001, 155:135-139.
108. Bachur R. Nonresponders: prolonged fever among infants with urinary tract infections. Pediatrics 2000, 105:e59.
109. Keren R., Chan E. A meta-analysis of randomized, controlled trials comparing short- and long-course antibiotic therapy for urinary tract infections in children. Pediatrics 2002, 109:e70.
110. Jones K.V. Time to review the value of imaging after urinary tract infection in infants. Arch Dis Child 2005, 90:663-665.
111. Marks S.D., Gordon I., Tullus K. Imaging in childhood urinary tract infections: time to reduce investigation. Pediatr Nephrol 2008, 23:9-17.
112. Montini G., Zucchetaa P., Tomasi L., et al. Value of imaging studies after a first febrile urinary tract infection in young children: data from Italian Renal Infection Study 1. Pediatrics 2009, 123:e239-e246.
113. Siomou E., Giapros V., Fotopoulos A., et al. Implications of 99mTc-DMSA scintigraphy performed during urinary tract infection in neonates. Pediatrics 2009, 124:881-887.
114. Sreenarasimhaiah S., Hellerstein S. Urinary tract infections per se do not cause end-stage kidney disease. Pediatr Nephrol 1998, 12:210-213.
115. Garin E.H., Olavarria F., Nieto V.G., et al. Clinical significance of primary vesicoureteral reflux and urinary antibiotic prophylaxis after acute pyelonephritis: a multicenter, randomized, controlled study. Pediatrics 2005, 117:626.
116. Williams G., Craig J.C. Prevention of recurrent urinary tract infection in children. Curr Opin Infect Dis 2009, 22:72-76.