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Volumn 18, Issue 2, 2006, Pages 148-152

Pathogenesis of urinary tract infection: An update

Author keywords

Innate immunity; Molecular pathogenesis; Urinary tract infection

Indexed keywords

CELL ADHESION MOLECULE; CHEMOKINE; CYTOKINE; DEFENSIN; PEPTIDE; TAMM HORSFALL GLYCOPROTEIN; TOLL LIKE RECEPTOR; TOLL LIKE RECEPTOR 4;

EID: 33646509465     PISSN: 10408703     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.mop.0000193276.39495.0d     Document Type: Review
Times cited : (68)

References (43)
  • 1
    • 4644298916 scopus 로고    scopus 로고
    • Functions of the renal tract epithelium in coordinating the innate immune response to infection
    • Chowdhury P, Sacks SH, Sheerin NS. Functions of the renal tract epithelium in coordinating the innate immune response to infection. Kidney Int 2004; 66:1334-1340. This paper illustrates the existence of TLRs, mainly TLR4, by human renal tract and bladder epithelia, which augment the innate immune responses after infections. It also gives a brief comparison of human and murine systems in immune responses.
    • (2004) Kidney Int , vol.66 , pp. 1334-1340
    • Chowdhury, P.1    Sacks, S.H.2    Sheerin, N.S.3
  • 2
    • 0031107555 scopus 로고    scopus 로고
    • Bacterial attachment to uroepithelial cells: Mechanisms and consequences
    • Connell H, Hedlund M, Agace W, Svanburg C. Bacterial attachment to uroepithelial cells: mechanisms and consequences. Adv Dent Res 1997; 11:50-58.
    • (1997) Adv Dent Res , vol.11 , pp. 50-58
    • Connell, H.1    Hedlund, M.2    Agace, W.3    Svanburg, C.4
  • 3
    • 0022389464 scopus 로고
    • Phagocytosis of bacteria by proximal tubular epithelium in experimental pyelonephritis
    • Ivanyi B, Krenacs T, Petri S. Phagocytosis of bacteria by proximal tubular epithelium in experimental pyelonephritis. Virchows Arch B Cell Pathol Incl Mol Pathol 1985; 50:59-70.
    • (1985) Virchows Arch B Cell Pathol Incl Mol Pathol , vol.50 , pp. 59-70
    • Ivanyi, B.1    Krenacs, T.2    Petri, S.3
  • 4
    • 0030991613 scopus 로고    scopus 로고
    • Internalization of E coli by human renal epithelial cells is associated with tyrosine phosphorylation of specific host proteins
    • Palmer LM, Reilly TJ, Utsalo SJ, Donnenberg MS. Internalization of E coli by human renal epithelial cells is associated with tyrosine phosphorylation of specific host proteins. Infect Immun 1997; 65:2570-2575.
    • (1997) Infect Immun , vol.65 , pp. 2570-2575
    • Palmer, L.M.1    Reilly, T.J.2    Utsalo, S.J.3    Donnenberg, M.S.4
  • 5
    • 0034255341 scopus 로고    scopus 로고
    • Bad bugs and beleaguered bladders. Interplay between uropathogenic Escherichia coli and innate host defenses
    • USA
    • Mulvey MA, Schiling JD, Martinez JJ, Hultgren SJ. Bad bugs and beleaguered bladders. Interplay between uropathogenic Escherichia coli and innate host defenses. Proc Natl Acad Sci USA 2000; 97:8829-8835.
    • (2000) Proc Natl Acad Sci , vol.97 , pp. 8829-8835
    • Mulvey, M.A.1    Schiling, J.D.2    Martinez, J.J.3    Hultgren, S.J.4
  • 6
    • 1642275654 scopus 로고    scopus 로고
    • Signaling danger: Toll-like receptors and their potential roles in kidney disease
    • Anders HJ, Banas B, Schlondorff D. Signaling danger: toll-like receptors and their potential roles in kidney disease. J Am Soc Nephrol 2004; 15:854-867. An excellent paper which provides a comprehensive review of innate immune responses through TLRs. It emphasizes the possible contributions of TLR activation of immune responses in tubulointerstitial injuries.
    • (2004) J Am Soc Nephrol , vol.15 , pp. 854-867
    • Anders, H.J.1    Banas, B.2    Schlondorff, D.3
  • 8
    • 0032509295 scopus 로고    scopus 로고
    • Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: Mutations in Tlr4 gene
    • Poltorak A, He X, Smirnova I, et al. Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: Mutations in Tlr4 gene. Science 1998; 282:2085-2088.
    • (1998) Science , vol.282 , pp. 2085-2088
    • Poltorak, A.1    He, X.2    Smirnova, I.3
  • 9
    • 0345561540 scopus 로고    scopus 로고
    • Endotoxin-tolerant mice have mutations in toll-like receptor 4
    • Quereshi ST, Lariviere L, Leveque G, et al. Endotoxin-tolerant mice have mutations in toll-like receptor 4. J Exp Med 1999; 189:615-625.
    • (1999) J Exp Med , vol.189 , pp. 615-625
    • Quereshi, S.T.1    Lariviere, L.2    Leveque, G.3
  • 10
    • 33646528858 scopus 로고    scopus 로고
    • Genetic factors in host resistance to urinary tract infections
    • Svanborg EC, Briles D, Habberg L, et al. Genetic factors in host resistance to urinary tract infections. Infection 2002; 12:1286-1293.
    • (2002) Infection , vol.12 , pp. 1286-1293
    • Svanborg, E.C.1    Briles, D.2    Habberg, L.3
  • 11
    • 1542377424 scopus 로고    scopus 로고
    • A toll-like receptor that prevents infection by uropathogenic bacteria
    • Zhang D, Zhang G, Hayden MS, et al. A toll-like receptor that prevents infection by uropathogenic bacteria. Science 2004; 303:1522-1526. This paper presents strong evidence that uropathogenic bacteria contain potential ligands for binding to TLR11. The authors speculate that the putative stop codon in human TLR11 might be a gene polymorphism indicating susceptibility of UTI.
    • (2004) Science , vol.303 , pp. 1522-1526
    • Zhang, D.1    Zhang, G.2    Hayden, M.S.3
  • 12
    • 1642306406 scopus 로고    scopus 로고
    • Ablation of the Tamm-Horsfall protein gene increases susceptibility of mice to bladder colonization by type 1-fimbriated Escherichia coli
    • Mo L, Zhu XH, Huang HY, et al. Ablation of the Tamm-Horsfall protein gene increases susceptibility of mice to bladder colonization by type 1-fimbriated Escherichia coli. Am J Physiol Renal Physiol 2004; 256:F795-F802. This paper provides a detailed mechanism of THP involvement in urogenital tract infections using THP gene knockout mice. It shows that THP mice are highly susceptible to THP fimbriated E. coli infections.
    • (2004) Am J Physiol Renal Physiol , vol.256
    • Mo, L.1    Zhu, X.H.2    Huang, H.Y.3
  • 13
    • 1342322652 scopus 로고    scopus 로고
    • Tamm-Horsfall protein knockout mice are more prone to urinary tract infection
    • Bates JM, Raffi HM, Prasadan K, et al. Tamm-Horsfall protein knockout mice are more prone to urinary tract infection. Kidney Int 2004; 65:791-797. This study shows that Tamm-Horsfall protein knockout mice are predisposed to urinary tract infection by type-I but not P-fimbriae E. coli.
    • (2004) Kidney Int , vol.65 , pp. 791-797
    • Bates, J.M.1    Raffi, H.M.2    Prasadan, K.3
  • 14
    • 17444381195 scopus 로고    scopus 로고
    • Tamm-Horsfall protein: A multilayered defence molecule against urinary tract infection
    • Saemann MD, Weichhart T, Horl WH, Zlabinger GJ. Tamm-Horsfall protein: a multilayered defence molecule against urinary tract infection. Eur J Clin Invest 2005; 35:227-235. A well organized review paper that summarizes the characteristics and mechanism of Tamm-Horsfall protein in urinary tract infection.
    • (2005) Eur J Clin Invest , vol.35 , pp. 227-235
    • Saemann, M.D.1    Weichhart, T.2    Horl, W.H.3    Zlabinger, G.J.4
  • 15
    • 20144373629 scopus 로고    scopus 로고
    • Tamm-Horsfall glycoprotein links innate immune cell activation with adaptive immunity via a Toll-like receptor-4 dependent mechanism
    • Saemann MD, Weichhart T, Zeyda M, et al. Tamm-Horsfall glycoprotein links innate immune cell activation with adaptive immunity via a Toll-like receptor-4 dependent mechanism. J Clin Invest 2005; 115:468-475. The paper reports the identification of one of THP protein receptors, Toll-like receptor 4 in innate immune response during THP.
    • (2005) J Clin Invest , vol.115 , pp. 468-475
    • Saemann, M.D.1    Weichhart, T.2    Zeyda, M.3
  • 16
    • 0019522857 scopus 로고
    • Mechanism of renal tissue destruction in an experimental acute pyelonephritis
    • Shimamura T. Mechanism of renal tissue destruction in an experimental acute pyelonephritis. Exp Mol Pathol 1981; 34:34-42.
    • (1981) Exp Mol Pathol , vol.34 , pp. 34-42
    • Shimamura, T.1
  • 17
    • 0017821070 scopus 로고
    • Prevention of chronic experimental pyelonephritis by suppression of acute suppuration
    • Glauser MP, Lyons JM, Braude AI. Prevention of chronic experimental pyelonephritis by suppression of acute suppuration. J Clin Invest 1978; 61:403-407.
    • (1978) J Clin Invest , vol.61 , pp. 403-407
    • Glauser, M.P.1    Lyons, J.M.2    Braude, A.I.3
  • 18
    • 0034917510 scopus 로고    scopus 로고
    • Epithelial secretion of C3 promotes colonization of the upper urinary tract by Escherichia coli
    • Springall T, Sheerin NS, Age K, et al. Epithelial secretion of C3 promotes colonization of the upper urinary tract by Escherichia coli. Nat Med 2001; 7:801-806.
    • (2001) Nat Med , vol.7 , pp. 801-806
    • Springall, T.1    Sheerin, N.S.2    Age, K.3
  • 19
    • 0030757758 scopus 로고    scopus 로고
    • Cytokine gene expression during experimental Escherichia coli pyelonephritis in mice
    • Khalil A, Brauner A, Bakhiet M, et al. Cytokine gene expression during experimental Escherichia coli pyelonephritis in mice. J Urol 1997; 158:1576-1580.
    • (1997) J Urol , vol.158 , pp. 1576-1580
    • Khalil, A.1    Brauner, A.2    Bakhiet, M.3
  • 20
    • 0033733962 scopus 로고    scopus 로고
    • Renal cytokine response in acute Escherichia coli pyelonephritis in IL-6 deficient mice
    • Khalil A, Tullus K, Bartfai T, et al. Renal cytokine response in acute Escherichia coli pyelonephritis in IL-6 deficient mice. Clin Exp Immunol 2000; 122:200-206.
    • (2000) Clin Exp Immunol , vol.122 , pp. 200-206
    • Khalil, A.1    Tullus, K.2    Bartfai, T.3
  • 21
    • 0028595615 scopus 로고
    • Urine interleukin-6 and interleukin-8 in children with acute pyelonephritis, in relation to DMSA scintigraphy in the acute phase and at 1-year follow up
    • Tullus K, Fitura O, Linne T, et al. Urine interleukin-6 and interleukin-8 in children with acute pyelonephritis, in relation to DMSA scintigraphy in the acute phase and at 1-year follow up. Pediatr Radiol 1994; 24:513-515.
    • (1994) Pediatr Radiol , vol.24 , pp. 513-515
    • Tullus, K.1    Fitura, O.2    Linne, T.3
  • 22
    • 33646533067 scopus 로고    scopus 로고
    • Soluble receptors to tumor necrosis factor and interleukin-6 in urine during acute pyelonephritis
    • Tullus K, Escobar-Billing R, Fituri O, et al. Soluble receptors to tumor necrosis factor and interleukin-6 in urine during acute pyelonephritis. J Urol 1998; 160:592-596.
    • (1998) J Urol , vol.160 , pp. 592-596
    • Tullus, K.1    Escobar-Billing, R.2    Fituri, O.3
  • 23
    • 0032499260 scopus 로고    scopus 로고
    • Chemokines and leukocyte traffic
    • Baggiolini M. Chemokines and leukocyte traffic. Nature 1998; 392:565-568.
    • (1998) Nature , vol.392 , pp. 565-568
    • Baggiolini, M.1
  • 24
    • 0032509889 scopus 로고    scopus 로고
    • Chemokines - Chemotactic cytokines that mediate inflammation
    • Lister AD. Chemokines - Chemotactic cytokines that mediate inflammation. N Engl J Med 1998; 338:436-445.
    • (1998) N Engl J Med , vol.338 , pp. 436-445
    • Lister, A.D.1
  • 25
    • 0028052968 scopus 로고
    • Interleukin 8 and related chemotactic cytokines. CXC and CC Chemokines
    • Baggiolini M, Dewald B, Moser B. Interleukin 8 and related chemotactic cytokines. CXC and CC Chemokines. Adv Immunol 1994; 55:97-179.
    • (1994) Adv Immunol , vol.55 , pp. 97-179
    • Baggiolini, M.1    Dewald, B.2    Moser, B.3
  • 26
    • 0034327734 scopus 로고    scopus 로고
    • Transepithelial neutrophil migration is CXCR1 dependent in vivo and is defective in IL-8 receptor knockout mice
    • Godaly G, Hang L, Frendeus B, Svanborg C. Transepithelial neutrophil migration is CXCR1 dependent in vivo and is defective in IL-8 receptor knockout mice. J Immunol 2000; 165:5287-5294.
    • (2000) J Immunol , vol.165 , pp. 5287-5294
    • Godaly, G.1    Hang, L.2    Frendeus, B.3    Svanborg, C.4
  • 27
    • 0033711755 scopus 로고    scopus 로고
    • Chemotactic activity of CXC chemokines interleukin-8, growth-related oncogene-alpha, and epithelial cell-derived neutrophil-activating protein-78 in urine of patients with urosepsis
    • Olszyna DP, Opal SM, Prins JM, et al. Chemotactic activity of CXC chemokines interleukin-8, growth-related oncogene-alpha, and epithelial cell-derived neutrophil-activating protein-78 in urine of patients with urosepsis. J Infect Dis 2000; 182:1731-1737.
    • (2000) J Infect Dis , vol.182 , pp. 1731-1737
    • Olszyna, D.P.1    Opal, S.M.2    Prins, J.M.3
  • 28
    • 19244363702 scopus 로고    scopus 로고
    • Interleukin-6 and interleukin-8 in children with febrile urinary tract infection and asymptomatic bacteriuria
    • Benson M, Jodal U, Agace W, et al. Interleukin-6 and interleukin-8 in children with febrile urinary tract infection and asymptomatic bacteriuria. J Infect Dis 1996; 174:1080-1084.
    • (1996) J Infect Dis , vol.174 , pp. 1080-1084
    • Benson, M.1    Jodal, U.2    Agace, W.3
  • 29
    • 0035044165 scopus 로고    scopus 로고
    • Escherichia coli P fimbriae utilize the Toll-like receptor 4 pathway for cell activation
    • Frendeus B, Wachtler C, Hedlund M, et al. Escherichia coli P fimbriae utilize the Toll-like receptor 4 pathway for cell activation. Mol Microbiol 2001; 40:37-51.
    • (2001) Mol Microbiol , vol.40 , pp. 37-51
    • Frendeus, B.1    Wachtler, C.2    Hedlund, M.3
  • 30
    • 2442519109 scopus 로고    scopus 로고
    • PapG-dependent adherence breaks mucosal inertia and triggers the innate host response
    • Bergsten G, Samuelsson M, Wullt B, et al. PapG-dependent adherence breaks mucosal inertia and triggers the innate host response. J Infect Dis 2004; 189:1734-1742.
    • (2004) J Infect Dis , vol.189 , pp. 1734-1742
    • Bergsten, G.1    Samuelsson, M.2    Wullt, B.3
  • 31
    • 0141799911 scopus 로고    scopus 로고
    • Defensins: Antimicrobial peptides of innate immunity
    • Ganz T. Defensins: Antimicrobial peptides of innate immunity. Nat Rev Immunol 2003; 3:710-720.
    • (2003) Nat Rev Immunol , vol.3 , pp. 710-720
    • Ganz, T.1
  • 32
    • 0032324337 scopus 로고    scopus 로고
    • Expression of intercellular adhesion molecule-1 in mice with pseudomonas-induced pyelonephritis
    • Yokoo A, Hirose T, Matsukawa M, et al. Expression of intercellular adhesion molecule-1 in mice with pseudomonas-induced pyelonephritis. J Urol 1998; 160:592-596.
    • (1998) J Urol , vol.160 , pp. 592-596
    • Yokoo, A.1    Hirose, T.2    Matsukawa, M.3
  • 33
    • 0027868045 scopus 로고
    • Adhesion molecule expression (ICAM-1, E-selectin and PECAM) in human kidney allografts
    • Gibbs P, Berkley LM, Bolton EM, et al. Adhesion molecule expression (ICAM-1, E-selectin and PECAM) in human kidney allografts. Transpl Immunol 1993; 1:109-113.
    • (1993) Transpl Immunol , vol.1 , pp. 109-113
    • Gibbs, P.1    Berkley, L.M.2    Bolton, E.M.3
  • 34
    • 0029115382 scopus 로고
    • Serum intercellular adhesion molecule (ICAM-1), a marker of renal scarring infants with vesico-ureteric reflux
    • Miyakita H, Puri P, Surana R, et al. Serum intercellular adhesion molecule (ICAM-1), a marker of renal scarring infants with vesico-ureteric reflux. Br J Urol 1995; 76:249-251.
    • (1995) Br J Urol , vol.76 , pp. 249-251
    • Miyakita, H.1    Puri, P.2    Surana, R.3
  • 35
    • 0030968927 scopus 로고    scopus 로고
    • Increased levels of circulating endothelial leukocyte adhesion molecule-1 (ELAM-1) in children with reflux nephropathy
    • Kobayashi H, Wang Y, Puri P. Increased levels of circulating endothelial leukocyte adhesion molecule-1 (ELAM-1) in children with reflux nephropathy. Eur Urol 1997; 31:343-346.
    • (1997) Eur Urol , vol.31 , pp. 343-346
    • Kobayashi, H.1    Wang, Y.2    Puri, P.3
  • 36
    • 0028043807 scopus 로고
    • Assessment of soluble adhesion molecules (s-ICAM-1, s-VCAM-1, s-ELAM-1) and complement cleavage products (SC4d, SC5b-9) in urine
    • Bechtel U, Scheuer R, Landgraf R, et al. Assessment of soluble adhesion molecules (s-ICAM-1, s-VCAM-1, s-ELAM-1) and complement cleavage products (SC4d, SC5b-9) in urine. Transplantation 1994; 58:905-911.
    • (1994) Transplantation , vol.58 , pp. 905-911
    • Bechtel, U.1    Scheuer, R.2    Landgraf, R.3
  • 37
    • 0036204267 scopus 로고    scopus 로고
    • Plasma and urine soluble adhesion molecule expression is increased during first documented acute pyelonephritis
    • Gbadegesom RG, Cotton SA, Couples BM, et al. Plasma and urine soluble adhesion molecule expression is increased during first documented acute pyelonephritis. Arch Dis Child 2002; 86:218-221.
    • (2002) Arch Dis Child , vol.86 , pp. 218-221
    • Gbadegesom, R.G.1    Cotton, S.A.2    Couples, B.M.3
  • 38
    • 0036790341 scopus 로고    scopus 로고
    • Polymorphisms of TLR-4: Rapid genotyping and reduced response to lipopolysaccharide of the TLR4 mutant alleles
    • Schmitt C, Humeny A, Becker CM, et al. Polymorphisms of TLR-4: rapid genotyping and reduced response to lipopolysaccharide of the TLR4 mutant alleles. Clin Chem 2002; 48:1661-1667.
    • (2002) Clin Chem , vol.48 , pp. 1661-1667
    • Schmitt, C.1    Humeny, A.2    Becker, C.M.3
  • 39
    • 0037071251 scopus 로고    scopus 로고
    • Relevance of mutations in the TLR4 receptor in patients with gram-negative septic shock
    • Lorenz E, Mira JP, Frees KL, Schwartz DA. Relevance of mutations in the TLR4 receptor in patients with gram-negative septic shock. Arch Intern Med 2002; 162:1028-1032.
    • (2002) Arch Intern Med , vol.162 , pp. 1028-1032
    • Lorenz, E.1    Mira, J.P.2    Frees, K.L.3    Schwartz, D.A.4
  • 40
    • 1842438611 scopus 로고    scopus 로고
    • Association between proinflammatory cytokines IL-6, IL-1b, IL-1RA and TNFa gene polymorphisms and acute pyelonephritis followed childhood urinary tract infection
    • Cotton SA, Gbadegesin RA, Watson CJ, et al. Association between proinflammatory cytokines IL-6, IL-1b, IL-1RA and TNFa gene polymorphisms and acute pyelonephritis followed childhood urinary tract infection. J Am Soc Nephrol 2000; 11:588A.
    • (2000) J Am Soc Nephrol , vol.11
    • Cotton, S.A.1    Gbadegesin, R.A.2    Watson, C.J.3
  • 41
    • 1842611585 scopus 로고    scopus 로고
    • Cytokines and cell adhesion molecules in the inflammatory response during acute pyelonephritis
    • Webb NJ, Brenchley PE. Cytokines and cell adhesion molecules in the inflammatory response during acute pyelonephritis. Nephron Exp Nephrol 2004; 96:e1-e6. This paper describes the effects of cytokines, adhesion molecules and growth factors in inflammatory responses during acute pyelonephritis. It provides a comprehensive list of all kidney genes involved.
    • (2004) Nephron Exp Nephrol , vol.96
    • Webb, N.J.1    Brenchley, P.E.2
  • 42
    • 0032983938 scopus 로고    scopus 로고
    • Implications of certain genetic polymorphisms in scarring in vesicoureteric reflux. Importance of ACE polymorphism
    • Ozen S, Alikasifogly M, Saatci U, et al. Implications of certain genetic polymorphisms in scarring in vesicoureteric reflux. Importance of ACE polymorphism. Am J Kidney Dis 1999; 34:140-145.
    • (1999) Am J Kidney Dis , vol.34 , pp. 140-145
    • Ozen, S.1    Alikasifogly, M.2    Saatci, U.3
  • 43
    • 0036952828 scopus 로고    scopus 로고
    • ACE gene polymorphism and renal scar in children with acute pyelonephritis
    • Cho SJ, Lee SJ. ACE gene polymorphism and renal scar in children with acute pyelonephritis. Pediatr Nephrol 2002; 17:491-495.
    • (2002) Pediatr Nephrol , vol.17 , pp. 491-495
    • Cho, S.J.1    Lee, S.J.2


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