In vitro effects of novel toothpaste actives on components of oral malodour

International Dental Journal

Volumn 61, Issue SUPPL. 3, 2011, Pages 67-73

  Burnett, Gary R ^a   Stephen, Abish S ^a,b   Pizzey, Robert L ^a   Bradshaw, David J ^a  

^a GLAXOSMITHKLINE   (United Kingdom)

^b KINGSTON UNIVERSITY   (United Kingdom)

Author keywords

Halitosis; o cymen 5 ol; volatile sulfur compounds; zinc

Indexed keywords

CHLORIDE; CYSTEINE; HYDROGEN SULFIDE; METHIONINE; O CYMEN 5 OL; O-CYMEN-5-OL; PHENOL DERIVATIVE; TOOTHPASTE; ZINC CHLORIDE; ZINC DERIVATIVE;

ARTICLE; BIOFILM; CHEMISTRY; DRUG EFFECT; HUMAN; METABOLISM; PLANKTON; PORPHYROMONAS GINGIVALIS;

BIOFILMS; CHLORIDES; CYSTEINE; HUMANS; HYDROGEN SULFIDE; METHIONINE; PHENOLS; PLANKTON; PORPHYROMONAS GINGIVALIS; TOOTHPASTES; ZINC COMPOUNDS;

EID: 79960527486     PISSN: 00206539     EISSN: 1875595X     Source Type: Journal    
DOI: 10.1111/j.1875-595X.2011.00052.x     Document Type: Article

References (42)

1. Delanghe G, Ghyselen J, Bollen C, et al., An inventory of patients' response to treatment at a multidisciplinary breath odor clinic. Quintessence Int 1999 30: 307-310.
2. Kleinberg I, Codipilly DM,. The Biological Basis of Oral Malodor Formation. In:, Rosenberg M, editor. Bad Breath: Research Perspectives. Tel Aviv: Ramot Publishing, 1997. p. 13-40.
3. De Boever EH, De Uzeda M, Loesche WJ,. Relationship between volatile sulfur compounds, BANA-hydrolyzing bacteria and gingival health in patients with and without complaints of oral malodor. J Clin Dent 1994 4: 114-119.
4. Koshimune S, Awano S, Gohara K, et al., Low salivary flow and volatile sulfur compounds in mouth air. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2003 96: 38-41. (Pubitemid 37490759)
5. Spratt DA, Pratten J,. Biofilms and the oral cavity. Rev Env Sci Biotechnol 2003 2: 109-120.
6. Lee CH, Kho HS, Chung SC, et al., The relationship between volatile sulfur compounds and major halitosis-inducing factors. J Periodontol 2003 74: 32-37.
7. Sanz M, Roldan S, Herrera D,. Fundamentals of breath malodour. J Contemp Dental Pract 2001 2: 1-13. (Pubitemid 38956718)
8. Allaker RP, Waite RD, Hickling J, et al., Topographic distribution of bacteria associated with oral malodour on the tongue. Arch Oral Biol 2008 53: S8-S12. (Pubitemid 351615149)
9. Tonzetich J, Richter VJ,. Evaluation of volatile odoriferous components of saliva. Arch Oral Biol 1964 9: 39-45.
10. Tonzetich J,. Direct gas chromatographic analysis of sulphur compounds in mouth air in man. Arch Oral Biol 1971 16: 587-597.
11. Greenman J, El Maaytah M, Duffield J, et al., Assessing the relationship between concentrations of malodor compounds and odor scores from judges. J Am Dent Assoc 2005 136: 749-757. (Pubitemid 40847607)
12. Bosy A, Kulkarni GV, Rosenberg M, et al., Relationship of oral malodor to periodontitis: evidence of independence in discrete subpopulations. J Periodontol 1994 65: 37-46.
13. Van Den Velde S, Quirynen M, Van Hee P, et al., Halitosis associated volatiles in breath of healthy subjects. J Chromatogr B Anal Technol Biomed Life Sci 2007 853: 54-61. (Pubitemid 46891332)
14. Tangerman A, Winkel EG,. The portable gas chromatograph OralChroma: a method of choice to detect oral and extra-oral halitosis. J Breath Res 2008 2: 17010.
15. Tsai CC, Chou HH, Wu TL, et al., The levels of volatile sulfur compounds in mouth air from patients with chronic periodontitis. J Periodontal Res 2008 43: 186-193.
16. Newby EE, Hickling JM, Hughes F, et al., Control of oral malodour by dentifrices measured by gas chromatography. Arch Oral Biol 2008 53: 519-525.
17. Rosenberg M, Kulkarni GV, Bosy A, et al., Reproducibility and sensitivity of oral malodor measurements with a portable sulphide monitor. J Dent Res 1991 70: 1436-1440.
18. Rosenberg M, Septon I, Eli I, Bar-Ness R, et al., Halitosis measurement by an industrial sulphide monitor. J Periodontol 2011 62: 487-489.
19. Outhouse TL, Al Alawi R, Fedorowicz Z, et al., Tongue scraping for treating halitosis. Cochrane Database Syst Rev 2006 2: Art No. CD005519.
20. Rosenberg M, Gelernter I, Barki M, et al., Day-long reduction of oral malodor by a two-phase oil: Water mouthrinse as compared to chlorhexidine and placebo rinses. J Periodontol 1992 63: 39-43.
21. Kim SE, Shim KM, Yoo KH, et al., The effect of cetylpyridinium chloride on halitosis and periodontal disease-related parameters in dogs. Biotechnol Bioprocess Eng 2008 13: 252-255. (Pubitemid 351689339)
22. Hur MH, Park J, Maddock-Jennings W, et al., Reduction of mouth malodour and volatile sulphur compounds in intensive care patients using an essential oil mouthwash. Phytother Res 2007 21: 641-643. (Pubitemid 47066777)
23. Phan TN, Buckner T, Sheng J, et al., Physiologic actions of zinc related to inhibition of acid and alkali production by oral streptococci in suspensions and biofilms. Oral Microbiol Immunol 2004 19: 31-38. (Pubitemid 38101502)
24. Sheng J, Nguyen PTM, Marquis RE,. Multi-target antimicrobial actions of zinc against oral anaerobes. Arch Oral Biol 2005 50: 747-757. (Pubitemid 40778440)
25. Young A, Jonski G, Rølla G, et al., Effects of metal salts on the oral production of Volatile Sulfur-containing Compounds VSC. J Clin Periodontol 2001 28: 776-781. (Pubitemid 33761319)
26. Bradshaw DJ, Perring KD, Cawkill PM, et al., Creation of oral care flavours to deliver breath-freshening benefits. Oral Dis 2005 11: 75-79. (Pubitemid 44944441)
27. Jonski G, Young A, Waler SM, Rolla G,. Insoluble zinc, cupric and tin pyrophosphates inhibit the formation of volatile sulphur compounds. Eur J Oral Sci 2004 112: 429-432. (Pubitemid 39456959)
28. Pratten J, Pasu M, Jackson G, et al., Modelling oral malodour in a longitudinal study. Arch Oral Biol 2003 48: 737-743. (Pubitemid 37274450)
29. Thorn RMS, Greenman J,. A novel in vitro flat-bed perfusion biofilm model for determining the potential antimicrobial efficacy of topical wound treatments. J Appl Microbiol 2009 107: 2070-2079.
30. Spencer P, Greenman J, McKenzie C, et al., In vitro biofilm model for studying tongue flora and malodour. J Appl Microbiol 2007 103: 985-992. (Pubitemid 47493246)
31. Greenman J, McKenzie C, Saad S, et al., Effects of chlorhexidine on a tongue-flora microcosm and VSC production using an in vitro biofilm perfusion model. J Breath Res 2008 2: 046005.
32. Taylor B, Greenman J,. Modelling the effects of pH on tongue biofilm using a sorbarod biofilm perfusion system. J Breath Res 2010 4: 017107.
33. Van Den Velde S, Van Steenberghe D, Van Hee P, et al., Detection of odorous compounds in breath. J Dent Res 2009 88: 285-289.
34. Pizzey RL, Marquis RE, Bradshaw DJ,. Antimicrobial effects of o-cymen-5-ol and zinc, alone and in combination in simple solutions and toothpaste formulations. Int Dent J 2011 61: 33-40.
35. Creeth JE, Abraham PJ, Barlow JA, et al., Oral delivery and clearance of antiplaque agents from Triclosan-containing dentifrices. Int Dent J 1993 43: 387-397.
36. Lynch RJM,. Zinc in the mouth, its interactions with dental enamel and possible effects on caries; a review of the literature. Int Dent J 2011 61: 46-54.
37. Saxton CA, Harrap GJ, Lloyd AM,. The effect of dentifrices containing zinc citrate on plaque growth and oral zinc levels. J Clin Periodontol 1986 13: 301-306. (Pubitemid 16087142)
38. Gilbert RJ,. The oral clearance of zinc and triclosan after delivery from a dentifrice. J Pharm Pharmacol 1987 39: 480-483. (Pubitemid 17114409)
39. Gilbert RJ, Ingram GS,. The oral disposition of zinc following the use of an anticalculus toothpaste containing 0.5% zinc citrate. J Pharm Pharmacol 1988 40: 399-402.
40. Harrap GJ, Best JS, Saxton CA,. Human oral retention of zinc from mouthwashes containing zinc salts and its relevance to dental plaque control. Arch Oral Biol 1984 29: 87-91.
41. Navada R, Kumari H, Le S, Zhang J,. Oral malodor reduction from a zinc-containing toothpaste. J Clin Dent 2008 19: 69-73.
42. Payne D, Gordon JJ, Nisbet S, et al., A randomised clinical trial to assess control of oral malodour by a novel dentifrice containing 0.1%w/w o-cymen-5-ol, 0.6%w/w zinc chloride. Int Dent J 2011 61: 21-27.