Analysis of sentinel node biopsy - a single-institution experience supporting the use of serial sectioning and immunohistochemistry for detection of micrometastases by comparing four different histopathological laboratory protocols

Histopathology

Volumn 59, Issue 1, 2011, Pages 129-138

  Grabau, Dorthe ^a,b   Ryden, Lisa ^a,b   Fernö, Mårten ^a,b   Ingvar, Christian ^a,b  

^a LUND UNIVERSITY HOSPITAL   (Sweden)

^b LUND UNIVERSITY   (Sweden)

Author keywords

Breast cancer; Immunohistochemistry; Isolated tumour cells; Micrometastases; Sentinel node biopsy

Indexed keywords

ADULT; ARTICLE; CANCER DIAGNOSIS; CONTROLLED STUDY; FALSE NEGATIVE RESULT; FEMALE; FROZEN SECTION; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MAJOR CLINICAL STUDY; MICROMETASTASIS; PATHOLOGIST; PRACTICE GUIDELINE; PRIORITY JOURNAL; SENTINEL LYMPH NODE BIOPSY; TISSUE SECTION;

AGED; AGED, 80 AND OVER; AXILLA; BREAST NEOPLASMS; FALSE NEGATIVE REACTIONS; FALSE POSITIVE REACTIONS; FEMALE; FROZEN SECTIONS; HISTOLOGICAL TECHNIQUES; HUMANS; IMMUNOHISTOCHEMISTRY; LYMPHATIC METASTASIS; MIDDLE AGED; NEOPLASM MICROMETASTASIS; NEOPLASM STAGING; SENTINEL LYMPH NODE BIOPSY; YOUNG ADULT;

EID: 79960465217     PISSN: 03090167     EISSN: 13652559     Source Type: Journal    
DOI: 10.1111/j.1365-2559.2011.03881.x     Document Type: Article

References (32)

1. Bergkvist L, Frisell J. Multicentre validation study of sentinel node biopsy for staging in breast cancer. Br. J. Surg. 2005; 92; 1221-1224.
2. Greene GL, Page DL, Fletcher C (eds). AJCC cancer staging manual, 6th edn. New York: Springer-Verlag, 2002.
3. Sobin LH, Wittenberg J (eds). TNM classification of malignant tumours, 6th edn. New York: Wiley, 2002.
4. Edge SB, Byrd DR, Compton CC, Fritz AG, Greene FL, Trotti A eds. AJCC cancer staging manual, 7th edn. New York: Springer Verlag, 2010.
5. Lester SC, Bose S, Chen YY et al. Protocol for the examination of specimens from patients with invasive carcinoma of the breast. Arch. Pathol. Lab. Med. 2009; 133; 1515-1538.
6. Perry N, Broeders M, de Wolf C, Tornberg S, Holland R, von Karsa L. European guidelines for quality assurance in breast cancer screening and diagnosis, 4th edn. European Breast Cancer Network (EBCN): Lyon, 2006; 329-331.
7. Layeequr RR, Siegel E, Boneti C et al. Stage migration with sentinel node biopsy in breast cancer. Am. J. Surg. 2009; 197; 491-496.
8. de Boer M, van Deurzen CH, van Dijck JA et al. Micrometastases or isolated tumor cells and the outcome of breast cancer. N. Engl. J. Med. 2009; 361; 653-663.
9. de Boer M, van Dijck JA, Bult P, Borm GF, Tjan-Heijnen VC. Breast cancer prognosis and occult lymph node metastases, isolated tumor cells, and micrometastases. J. Natl Cancer Inst. 2010; 102; 410-425.
10. Patani N, Mokbel K. The clinical significance of sentinel lymph node micrometastasis in breast cancer. Breast Cancer Res. Treat. 2009; 114; 393-402.
11. Tan LK, Giri D, Hummer AJ et al. Occult axillary node metastases in breast cancer are prognostically significant: results in 368 node-negative patients with 20-year follow-up. J. Clin. Oncol. 2008; 26; 1803-1809.
12. Andersson Y, Frisell J, Sylvan M, de Boniface J, Bergkvist L. Breast cancer survival in relation to the metastatic tumor burden in axillary lymph nodes. J. Clin. Oncol. 2010; 28; 2868-2873.
13. Gobardhan PD, Elias SG, Madsen EV et al. Prognostic value of micrometastases in sentinel lymph nodes of patients with breast carcinoma: a cohort study. Ann. Oncol. 2009; 20; 41-48.
14. Sobin LH, Gospodarowicz MK, Wittekind C (eds). UICC International Union against Cancer. TNM classification of malignant tumours, 7th edn. Oxford: Wiley-Blackwell, 2009.
15. Elston CW, Ellis IO. Pathological prognostic factors in breast cancer I. The value of histological grade in breast cancer: experience from a large study with long-term follow-up. Histopathology 1991; 19; 403-410.
16. Bloom HJG, Richardson WW. Histological grading and prognosis in breast cancer. A study of 1409 cases of which 359 have been followed for 15years. Br. J. Cancer 1957; 11; 359-377.
17. Jaffer S, Nagi C, Bleiweiss IJ. Occult axillary node metastases in breast cancer are prognostically significant: results in 368 node negative patients with 20-year follow-up. Adv. Anat. Pathol. 2008; 15; 370-373.
18. Sahin AA, Guray M, Hunt KK. Identification and biologic significance of micrometastases in axillary lymph nodes in patients with invasive breast cancer. Arch. Pathol. Lab. Med. 2009; 133; 869-878.
19. Celebioglu F, Sylvan M, Perbeck L, Bergkvist L, Frisell J. Intraoperative sentinel lymph node examination by frozen section, immunohistochemistry and imprint cytology during breast surgery - a prospective study. Eur. J. Cancer 2006; 42; 617-620.
20. Ryden L, Chebil G, Sjostrom L, Pawlowski R, Jonsson PE. Determination of sentinel lymph node (SLN) status in primary breast cancer by prospective use of immunohistochemistry increases the rate of micrometastases and isolated tumour cells: analysis of 174 patients after SLN biopsy. Eur. J. Surg. Oncol. 2007; 33; 33-38.
21. Morrow M. Patterns of care with a positive sentinel node: echoes of an opportunity missed. Ann. Surg. Oncol. 2009; 16; 2429-2430.
22. Grabau D. Breast cancer patients with micrometastases only: is a basis provided for tailored treatment? Surg. Oncol. 2008; 17; 211-217.
23. Groen RS, Oosterhuis AW, Boers JE. Pathologic examination of sentinel lymph nodes in breast cancer by a single haematoxylin-eosin slide versus serial sectioning and immunocytokeratin staining: clinical implications. Breast Cancer Res. Treat. 2007; 105; 1-5.
24. Diaz NM, Cox CE, Ebert M et al. Benign mechanical transport of breast epithelial cells to sentinel lymph nodes. Am. J. Surg. Pathol. 2004; 28; 1641-1645.
25. Hansen NM, Ye X, Grube BJ, Giuliano AE. Manipulation of the primary breast tumor and the incidence of sentinel node metastases from invasive breast cancer. Arch. Surg. 2004; 139; 634-639.
26. Bleiweiss IJ, Nagi CS, Jaffer S. Axillary sentinel lymph nodes can be falsely positive due to iatrogenic displacement and transport of benign epithelial cells in patients with breast carcinoma. J. Clin. Oncol. 2006; 24; 2013-2018.
27. Cserni G. A model for determining the optimum histology of sentinel lymph nodes in breast cancer. J. Clin. Pathol. 2004; 57; 467-471.
28. Madsen EV, van Dalen J, van Gorp J, Borel Rinkes I, van Dalen T. Strategies for optimizing pathologic staging of sentinel lymph nodes in breast cancer patients. Virchows Arch. 2008; 453; 17-24.
29. Turner RR, Weaver DL, Cserni G et al. Nodal stage classification for breast carcinoma: improving interobserver reproducibility through standardized histologic criteria and image-based training. J. Clin. Oncol. 2008; 26; 258-263.
30. Cserni G, Amendoeira I, Apostolikas N et al. Pathological work-up of sentinel lymph nodes in breast cancer. Review of current data to be considered for the formulation of guidelines. Eur. J. Cancer 2003; 39; 1654-1667.
31. Pantanowitz L, Upton MP. Benign axillary lymph node inclusions. Breast J. 2003; 9; 56-57.
32. Haraldsdottir KH, Ivarsson K, Gotberg S, Ingvar C, Stenram U, Tranberg KG. Interstitial laser thermotherapy (ILT) of breast cancer. Eur. J. Surg. Oncol. 2008; 34; 739-745.