Chromium-VI arrests cell cycle and decreases granulosa cell proliferation by down-regulating cyclin-dependent kinases (CDK) and cyclins and up-regulating CDK-inhibitors

Reproductive Toxicology

Volumn 32, Issue 1, 2011, Pages 112-123

  Stanley, Jone A ^a   Lee, JeHoon ^a   Nithy, Thamizh K ^a   Arosh, Joe A ^a   Burghardt, Robert C ^a   Banu, Sakhila K ^a  

^a TEXAS A AND M UNIVERSITY   (United States)

Author keywords

CDK inhibitors; Cell cycle; Cyclin dependent kinases; Cyclins; ER ; FSH receptor; Granulosa cells; Hexavalent chromium; Ovary; Vitamin C

Indexed keywords

ASCORBIC ACID; CELL CYCLE PROTEIN; CHROMIUM; CYCLIN A; CYCLIN B1; CYCLIN D1; CYCLIN D2; CYCLIN D3; CYCLIN D4; CYCLIN D6; CYCLIN DEPENDENT KINASE; CYCLIN DEPENDENT KINASE 1; CYCLIN DEPENDENT KINASE 2; CYCLIN DEPENDENT KINASE 4; CYCLIN DEPENDENT KINASE 6; CYCLIN DEPENDENT KINASE INHIBITOR; CYCLIN E; CYCLIN E2; CYCLINE; DICHROMATE POTASSIUM; ESTROGEN RECEPTOR BETA; FOLLITROPIN RECEPTOR; PROTEIN P15; PROTEIN P16; PROTEIN P27; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL CYCLE; CELL CYCLE ARREST; CELL CYCLE G1 PHASE; CELL CYCLE G2 PHASE; CELL CYCLE M PHASE; CELL CYCLE REGULATION; CELL CYCLE S PHASE; CELL IMMORTALIZATION; CELL PROLIFERATION; CONTROLLED STUDY; DOWN REGULATION; FEMALE; GRANULOSA CELL; NONHUMAN; PROTEIN EXPRESSION; RAT; UPREGULATION;

ANIMALS; ANTIOXIDANTS; APOPTOSIS; ASCORBIC ACID; CARCINOGENS, ENVIRONMENTAL; CELL CYCLE; CELL LINE, TRANSFORMED; CELL PROLIFERATION; CHROMIUM; CYCLIN-DEPENDENT KINASES; CYCLINS; DRUG ANTAGONISM; FEMALE; GENE EXPRESSION REGULATION; GRANULOSA CELLS; POTASSIUM DICHROMATE; PROLIFERATING CELL NUCLEAR ANTIGEN; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, ESTROGEN; RECEPTORS, FSH; RNA, MESSENGER;

RATTUS;

EID: 79960456424     PISSN: 08906238     EISSN: 18731708     Source Type: Journal    
DOI: 10.1016/j.reprotox.2011.05.007     Document Type: Article

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