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Volumn 36, Issue 1, 2009, Pages 1-5

FSHb knockout mouse model: A decade ago and into the future

Author keywords

FSH; Gene targeting; Gonads; Pituitary; Transgene

Indexed keywords

FOLLITROPIN BETA SUBUNIT;

EID: 64849117887     PISSN: 1355008X     EISSN: 15590100     Source Type: Journal    
DOI: 10.1007/s12020-009-9199-6     Document Type: Review
Times cited : (15)

References (41)
  • 1
    • 24944486224 scopus 로고    scopus 로고
    • What have we learned about gonadotropin function from gonadotropin subunit and receptor knockout mice?
    • T.R. Kumar, What have we learned about gonadotropin function from gonadotropin subunit and receptor knockout mice? Reproduction 130, 293-302 (2005)
    • (2005) Reproduction , vol.130 , pp. 293-302
    • Kumar, T.R.1
  • 2
    • 24644485951 scopus 로고    scopus 로고
    • Gonadotropin gene targeting and biological implications
    • T.R. Kumar, Gonadotropin gene targeting and biological implications. Endocrine 26, 227-233 (2005)
    • (2005) Endocrine , vol.26 , pp. 227-233
    • Kumar, T.R.1
  • 3
    • 33751249619 scopus 로고    scopus 로고
    • Mouse models for gonadotropins: A 15-year saga
    • T.R. Kumar, Mouse models for gonadotropins: A 15-year Saga. Mol. Cell. Endocrinol. 260-262, 249-254 (2007)
    • (2007) Mol. Cell. Endocrinol. , vol.260-262 , pp. 249-254
    • Kumar, T.R.1
  • 4
    • 0031864904 scopus 로고    scopus 로고
    • Is there a true requirement for follicle stimulating hormone in promoting spermatogenesis and fertility in primates?
    • N.R. Moudgal, M.R. Sairam, Is there a true requirement for follicle stimulating hormone in promoting spermatogenesis and fertility in primates? Hum. Reprod. 13, 916-919 (1998)
    • (1998) Hum. Reprod. , vol.13 , pp. 916-919
    • Moudgal, N.R.1    Sairam, M.R.2
  • 7
    • 0026621796 scopus 로고
    • Alpha-inhibin is a tumour-suppressor gene with gonadal specificity in mice
    • M.M. Matzuk, M.J. Finegold, J.G. Su, A.J. Hsueh, A. Bradley, Alpha-inhibin is a tumour-suppressor gene with gonadal specificity in mice. Nature 360, 313-319 (1992)
    • (1992) Nature , vol.360 , pp. 313-319
    • Matzuk, M.M.1    Finegold, M.J.2    Su, J.G.3    Hsueh, A.J.4    Bradley, A.5
  • 8
    • 0031054284 scopus 로고    scopus 로고
    • Follicle stimulating hormone is required for ovarian follicle maturation but not male fertility
    • T.R. Kumar, Y. Wang, N. Lu, M.M. Matzuk, Follicle stimulating hormone is required for ovarian follicle maturation but not male fertility. Nat. Genet. 15, 201-204 (1997)
    • (1997) Nat. Genet. , vol.15 , pp. 201-204
    • Kumar, T.R.1    Wang, Y.2    Lu, N.3    Matzuk, M.M.4
  • 9
    • 0027257561 scopus 로고
    • Gonadal steroid hormone regulation of human and mouse follicle stimulating hormone beta-subunit gene expression in vivo
    • T.R. Kumar, M.J. Low, Gonadal steroid hormone regulation of human and mouse follicle stimulating hormone beta-subunit gene expression in vivo. Mol. Endocrinol. 7, 898-906 (1993)
    • (1993) Mol. Endocrinol. , vol.7 , pp. 898-906
    • Kumar, T.R.1    Low, M.J.2
  • 10
    • 0024332617 scopus 로고
    • Isolation and characterization of the gene encoding the beta-subunit of rat follicle-stimulating hormone
    • S.D. Gharib, A. Roy, M.E. Wierman, W.W. Chin, Isolation and characterization of the gene encoding the beta-subunit of rat follicle-stimulating hormone. DNA 8, 339-349 (1989)
    • (1989) DNA , vol.8 , pp. 339-349
    • Gharib, S.D.1    Roy, A.2    Wierman, M.E.3    Chin, W.W.4
  • 11
    • 0023735072 scopus 로고
    • Human follicle-stimulating hormone beta-subunit gene encodes multiple messenger ribonucleic acids
    • J.L. Jameson, C.B. Becker, C.M. Lindell, J.F. Habener, Human follicle-stimulating hormone beta-subunit gene encodes multiple messenger ribonucleic acids. Mol. Endocrinol. 2, 806-815 (1988)
    • (1988) Mol. Endocrinol. , vol.2 , pp. 806-815
    • Jameson, J.L.1    Becker, C.B.2    Lindell, C.M.3    Habener, J.F.4
  • 12
    • 0029618456 scopus 로고
    • Cloning of the mouse gonadotropin beta-subunit-encoding genes, I. Structure of the follicle-stimulating hormone beta-subunitencoding gene
    • T.R. Kumar, M. Kelly, M. Mortrud, M.J. Low, M.M. Matzuk, Cloning of the mouse gonadotropin beta-subunit-encoding genes, I. Structure of the follicle-stimulating hormone beta-subunitencoding gene. Gene 166, 333-334 (1995)
    • (1995) Gene , vol.166 , pp. 333-334
    • Kumar, T.R.1    Kelly, M.2    Mortrud, M.3    Low, M.J.4    Matzuk, M.M.5
  • 13
    • 1842376911 scopus 로고    scopus 로고
    • Men homozygous for an inactivating mutation of the follicle-stimulating hormone (FSH) receptor gene present variable suppression of spermatogenesis and fertility
    • J.S. Tapanainen, K. Aittomaki, J. Min, T. Vaskivuo, I.T. Huhtaniemi, Men homozygous for an inactivating mutation of the follicle-stimulating hormone (FSH) receptor gene present variable suppression of spermatogenesis and fertility. Nat. Genet. 15, 205-206 (1997)
    • (1997) Nat. Genet. , vol.15 , pp. 205-206
    • Tapanainen, J.S.1    Aittomaki, K.2    Min, J.3    Vaskivuo, T.4    Huhtaniemi, I.T.5
  • 15
    • 0022450230 scopus 로고
    • Chronic human chorionic gonadotropin administration in normal men: Evidence that follicle-stimulating hormone is necessary for the maintenance of quantitatively normal spermatogenesis in man
    • A.M. Matsumoto, A.E. Karpas, W.J. Bremner, Chronic human chorionic gonadotropin administration in normal men: Evidence that follicle-stimulating hormone is necessary for the maintenance of quantitatively normal spermatogenesis in man. J. Clin. Endocrinol. Metab. 62, 1184-1192 (1986)
    • (1986) J. Clin. Endocrinol. Metab. , vol.62 , pp. 1184-1192
    • Matsumoto, A.M.1    Karpas, A.E.2    Bremner, W.J.3
  • 16
    • 0030994256 scopus 로고    scopus 로고
    • Immunization of male bonnet monkeys (M. radiata) with a recombinant FSH receptor preparation affects testicular function and fertility
    • N.R. Moudgal, M.R. Sairam, H.N. Krishnamurthy, S. Sridhar, H. Krishnamurthy, H. Khan, Immunization of male bonnet monkeys (M. radiata) with a recombinant FSH receptor preparation affects testicular function and fertility. Endocrinology 38, 3065-3068 (1997)
    • (1997) Endocrinology , vol.38 , pp. 3065-3068
    • Moudgal, N.R.1    Sairam, M.R.2    Krishnamurthy, H.N.3    Sridhar, S.4    Krishnamurthy, H.5    Khan, H.6
  • 17
    • 0029800257 scopus 로고    scopus 로고
    • Neonatal administration of FSH increases Sertoli cell numbers and spermatogenesis in gonadotropin-deficient (hpg) mice
    • J. Singh, D.J. Handelsman, Neonatal administration of FSH increases Sertoli cell numbers and spermatogenesis in gonadotropin-deficient (hpg) mice. J. Endocrinol. 151, 37-48 (1996)
    • (1996) J. Endocrinol. , vol.151 , pp. 37-48
    • Singh, J.1    Handelsman, D.J.2
  • 18
    • 0036956875 scopus 로고    scopus 로고
    • Studying gene function in eukaryotes by conditional gene inactivation
    • M. Gossen, H. Bujard, Studying gene function in eukaryotes by conditional gene inactivation. Annu. Rev. Genet. 36, 153-173 (2002)
    • (2002) Annu. Rev. Genet. , vol.36 , pp. 153-173
    • Gossen, M.1    Bujard, H.2
  • 20
  • 21
    • 0036193248 scopus 로고    scopus 로고
    • Robust and efficient regulation of transgene expression in vivo by improved tetracycline-dependent lentiviral vectors
    • E. Vigna, S. Cavalieri, L. Ailles, M. Geuna, R. Loew, H. Bujard, L. Naldini, Robust and efficient regulation of transgene expression in vivo by improved tetracycline-dependent lentiviral vectors. Mol. Ther. 5, 252-261 (2002)
    • (2002) Mol. Ther. , vol.5 , pp. 252-261
    • Vigna, E.1    Cavalieri, S.2    Ailles, L.3    Geuna, M.4    Loew, R.5    Bujard, H.6    Naldini, L.7
  • 22
    • 0037225516 scopus 로고    scopus 로고
    • Failure of normal Leydig cell development in follicle-stimulating hormone (FSH) receptor-deficient mice, but not FSHbeta-deficient mice: Role for constitutive FSH receptor activity
    • P.J. Baker, P. Pakarinen, I.T. Huhtaniemi, M.H. Abel, H.M. Charlton, T.R. Kumar, P.J. O'Shaughnessy, Failure of normal Leydig cell development in follicle-stimulating hormone (FSH) receptor-deficient mice, but not FSHbeta-deficient mice: Role for constitutive FSH receptor activity. Endocrinology 144, 138-145 (2003)
    • (2003) Endocrinology , vol.144 , pp. 138-145
    • Baker, P.J.1    Pakarinen, P.2    Huhtaniemi, I.T.3    Abel, M.H.4    Charlton, H.M.5    Kumar, T.R.6    O'Shaughnessy, P.J.7
  • 23
    • 0033304622 scopus 로고    scopus 로고
    • Transgenic models to study gonadotropin function: The role of follicle-stimulating hormone in gonadal growth and tumorigenesis
    • T.R. Kumar, G. Palapattu, P. Wang, T.K. Woodruff, I. Boime, M.C. Byrne, M.M. Matzuk, Transgenic models to study gonadotropin function: The role of follicle-stimulating hormone in gonadal growth and tumorigenesis. Mol. Endocrinol. 13, 851-865 (1999)
    • (1999) Mol. Endocrinol. , vol.13 , pp. 851-865
    • Kumar, T.R.1    Palapattu, G.2    Wang, P.3    Woodruff, T.K.4    Boime, I.5    Byrne, M.C.6    Matzuk, M.M.7
  • 24
    • 0026536284 scopus 로고
    • Gonadotropespecific expression of the human follicle-stimulating hormone beta-subunit gene in pituitaries of transgenic mice
    • T.R. Kumar, V. Fairchild-Huntress, M.J. Low, Gonadotropespecific expression of the human follicle-stimulating hormone beta-subunit gene in pituitaries of transgenic mice. Mol. Endocrinol. 6, 81-90 (1992)
    • (1992) Mol. Endocrinol. , vol.6 , pp. 81-90
    • Kumar, T.R.1    Fairchild-Huntress, V.2    Low, M.J.3
  • 25
    • 0031788317 scopus 로고    scopus 로고
    • Genetic rescue of folliclestimulating hormone beta-deficient mice
    • T.R. Kumar, M.J. Low, M.M. Matzuk, Genetic rescue of folliclestimulating hormone beta-deficient mice. Endocrinology 139, 3289-3295 (1998)
    • (1998) Endocrinology , vol.139 , pp. 3289-3295
    • Kumar, T.R.1    Low, M.J.2    Matzuk, M.M.3
  • 26
    • 12344278940 scopus 로고    scopus 로고
    • A single-chain tetradomain glycoprotein hormone analog elicits multiple hormone activities in vivo
    • V. Garcia-Campayo, I. Boime, X. Ma, D. Daphna-Iken, T.R. Kumar, A single-chain tetradomain glycoprotein hormone analog elicits multiple hormone activities in vivo. Biol. Reprod. 72, 301-308 (2005)
    • (2005) Biol. Reprod. , vol.72 , pp. 301-308
    • Garcia-Campayo, V.1    Boime, I.2    Ma, X.3    Daphna-Iken, D.4    Kumar, T.R.5
  • 27
    • 33744472176 scopus 로고    scopus 로고
    • Single-chain, triple-domain gonadotropin analogs with disulfide bond mutations in the alpha-subunit elicit dual follitropin and lutropin activities in vivo
    • A. Jablonka-Shariff, T.R. Kumar, J. Eklund, A. Comstock, I. Boime, Single-chain, triple-domain gonadotropin analogs with disulfide bond mutations in the alpha-subunit elicit dual follitropin and lutropin activities in vivo. Mol. Endocrinol. 20, 1437-1446 (2006)
    • (2006) Mol. Endocrinol. , vol.20 , pp. 1437-1446
    • Jablonka-Shariff, A.1    Kumar, T.R.2    Eklund, J.3    Comstock, A.4    Boime, I.5
  • 28
    • 0034984222 scopus 로고    scopus 로고
    • Analysis of the testicular phenotype of the folliclestimulating hormone beta-subunit knockout and the activin type II receptor knockout mice by stereological analysis
    • N.G. Wreford, T. Rajendra Kumar, M.M. Matzuk, D.M. de Kretser, Analysis of the testicular phenotype of the folliclestimulating hormone beta-subunit knockout and the activin type II receptor knockout mice by stereological analysis. Endocrinology 142, 2916-2920 (2001)
    • (2001) Endocrinology , vol.142 , pp. 2916-2920
    • Wreford, N.G.1    Rajendra Kumar, T.2    Matzuk, M.M.3    De Kretser, D.M.4
  • 29
    • 0345827710 scopus 로고    scopus 로고
    • Regulation of Sertoli cell number and activity by follicle-stimulating hormone and androgen during postnatal development in the mouse
    • H. Johnston, P.J. Baker, M. Abel, H.M. Charlton, G. Jackson, L. Fleming, T.R. Kumar, P.J. O'Shaughnessy, Regulation of Sertoli cell number and activity by follicle-stimulating hormone and androgen during postnatal development in the mouse. Endocrinology 145, 318-329 (2004)
    • (2004) Endocrinology , vol.145 , pp. 318-329
    • Johnston, H.1    Baker, P.J.2    Abel, M.3    Charlton, H.M.4    Jackson, G.5    Fleming, L.6    Kumar, T.R.7    O'Shaughnessy, P.J.8
  • 30
    • 0242440967 scopus 로고    scopus 로고
    • Follicle-stimulating hormone increases testicular anti-Mullerian hormone (AMH) production through sertoli cell proliferation and a nonclassical cyclic adenosine 50-monophosphate-mediated activation of the AMH
    • C. Lukas-Croisier, C. Lasala, J. Nicaud, P. Bedecarras, T.R. Kumar, M. Dutertre, M.M. Matzuk, J.Y. Picard, N. Josso, R. Rey, Follicle-stimulating hormone increases testicular anti-Mullerian hormone (AMH) production through sertoli cell proliferation and a nonclassical cyclic adenosine 50-monophosphate-mediated activation of the AMH Gene. Mol. Endocrinol. 17, 550-561 (2003)
    • (2003) Gene. Mol. Endocrinol. , vol.17 , pp. 550-561
    • Lukas-Croisier, C.1    Lasala, C.2    Nicaud, J.3    Bedecarras, P.4    Kumar, T.R.5    Dutertre, M.6    Matzuk, M.M.7    Picard, J.Y.8    Josso, N.9    Rey, R.10
  • 31
    • 33745119083 scopus 로고    scopus 로고
    • Spermatogonial differentiation in juvenile spermatogonial depletion (jsd) mice with androgen receptor or follicle-stimulating hormone mutations
    • G. Shetty, C.C. Weng, K.L. Porter, Z. Zhang, P. Pakarinen, T.R. Kumar, M.L. Meistrich, Spermatogonial differentiation in juvenile spermatogonial depletion (jsd) mice with androgen receptor or follicle-stimulating hormone mutations. Endocrinology 147, 3563-3570 (2006)
    • (2006) Endocrinology , vol.147 , pp. 3563-3570
    • Shetty, G.1    Weng, C.C.2    Porter, K.L.3    Zhang, Z.4    Pakarinen, P.5    Kumar, T.R.6    Meistrich, M.L.7
  • 33
    • 15644372263 scopus 로고    scopus 로고
    • Insulin-like growth factor i regulates gonadotropin responsiveness in the murine ovary
    • J. Zhou, T.R. Kumar, M.M. Matzuk, C. Bondy, Insulin-like growth factor I regulates gonadotropin responsiveness in the murine ovary. Mol. Endocrinol. 11, 1924-1933 (1997)
    • (1997) Mol. Endocrinol. , vol.11 , pp. 1924-1933
    • Zhou, J.1    Kumar, T.R.2    Matzuk, M.M.3    Bondy, C.4
  • 36
    • 33845438196 scopus 로고    scopus 로고
    • Handelsman sex steroids not fsh influence bone mass
    • Author Reply 1080-1071 37
    • M.J. Seibel, C.R. Dunstan, H. Zhou, C.M. Allan, D.J. Handelsman, Sex steroids, not FSH, influence bone mass. Cell 127, 1079 (2006). author reply 1080-1071 37.
    • (2006) Cell , vol.127 , pp. 1079
    • Seibel, M.J.1    Dunstan, C.R.2    Zhou, H.3    Allan, C.M.4    Handelsman, D.J.5
  • 37
    • 24644449614 scopus 로고    scopus 로고
    • Targeting gonadotropin receptor genes: Reproductive biology, aging, and related health implications
    • N. Danilovich, M.R. Sairam, Targeting gonadotropin receptor genes: Reproductive biology, aging, and related health implications. Endocrine 26, 219-226 (2005)
    • (2005) Endocrine , vol.26 , pp. 219-226
    • Danilovich, N.1    Sairam, M.R.2
  • 38
    • 0032506018 scopus 로고    scopus 로고
    • Impairing follicle-stimulating hormone (FSH) signaling in vivo: Targeted disruption of the FSH receptor leads to aberrant gametogenesis and hormonal imbalance
    • A. Dierich, M.R. Sairam, L. Monaco, G.M. Fimia, A. Gansmuller, M. LeMeur, P. Sassone-Corsi, Impairing follicle-stimulating hormone (FSH) signaling in vivo: Targeted disruption of the FSH receptor leads to aberrant gametogenesis and hormonal imbalance. Proc. Natl Acad. Sci. USA 95, 13612-13617 (1998)
    • (1998) Proc. Natl Acad. Sci. USA , vol.95 , pp. 13612-13617
    • Dierich, A.1    Sairam, M.R.2    Monaco, L.3    Fimia, G.M.4    Gansmuller, A.5    LeMeur, M.6    Sassone-Corsi, P.7
  • 39
    • 0345269980 scopus 로고    scopus 로고
    • Age-related uterine and ovarian hypertrophy in FSH receptor knockout and FSHbeta subunit knockout mice
    • M.H. Abel, I. Huhtaniemi, P. Pakarinen, T.R. Kumar, H.M. Charlton, Age-related uterine and ovarian hypertrophy in FSH receptor knockout and FSHbeta subunit knockout mice. Reproduction 125, 165-173 (2003)
    • (2003) Reproduction , vol.125 , pp. 165-173
    • Abel, M.H.1    Huhtaniemi, I.2    Pakarinen, P.3    Kumar, T.R.4    Charlton, H.M.5
  • 40
    • 0035013450 scopus 로고    scopus 로고
    • An overview of the past, present, and future of nongonadal LH/hCG actions in reproductive biology and medicine
    • C.V. Rao, An overview of the past, present, and future of nongonadal LH/hCG actions in reproductive biology and medicine. Semin. Reprod. Med. 19, 7-17 (2001)
    • (2001) Semin. Reprod. Med. , vol.19 , pp. 7-17
    • Rao, C.V.1
  • 41
    • 33947609974 scopus 로고    scopus 로고
    • The past, present and future of nongonadal LH/hCG actions in reproductive biology and medicine
    • C.V. Rao, Z.M. Lei, The past, present and future of nongonadal LH/hCG actions in reproductive biology and medicine. Mol. Cell. Endocrinol. 269, 2-8 (2007)
    • (2007) Mol. Cell. Endocrinol. , vol.269 , pp. 2-8
    • Rao, C.V.1    Lei, Z.M.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.