Modulation of TRIM5α activity in human cells by alternatively spliced TRIM5 isoforms

Journal of Virology

Volumn 85, Issue 15, 2011, Pages 7828-7835

  Battivelli, Emilie ^a,b   Migraine, Julie ^a,b   Lecossier, Denise ^a,b   Matsuoka, Saori ^a,b,d   Perez Bercoff, Danielle ^a,b   Saragosti, Sentob ^a,b   Clavel, François ^a,b   Hance, Allan J ^a,b,c  

^a INSERM   (France)

^b UNIVERSITÉ PARIS DIDEROT   (France)

^c BICHAT HOSPITAL   (France)

^d NATIONAL INSTITUTE OF INFECTIOUS DISEASES   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ISOPROTEIN; MESSENGER RNA; TRIPARTITE MOTIF PROTEIN 5; TRIPARTITE MOTIF PROTEIN 5 DELTA; TRIPARTITE MOTIF PROTEIN 5 GAMMA; TRIPARTITE MOTIF PROTEIN 5 IOTA; TRIPARTITE MOTIF PROTEIN 5 KAPPA; UNCLASSIFIED DRUG; CARRIER PROTEIN; TRIM5 PROTEIN, HUMAN;

ANTIVIRAL ACTIVITY; ARTICLE; BIOTINYLATION; CD4+ T LYMPHOCYTE; CONTROLLED STUDY; ENZYME ACTIVITY; EXPRESSED SEQUENCE TAG; GENE OVEREXPRESSION; GENETIC TRANSCRIPTION; GENETIC VARIABILITY; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; MACROPHAGE; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; RNA SPLICING; VIRUS REPLICATION; VIRUS STRAIN; ALTERNATIVE RNA SPLICING; CELL LINE; CHEMISTRY; GENE SILENCING; GENETICS; PHYSIOLOGY; POLYMERASE CHAIN REACTION; WESTERN BLOTTING;

HUMAN IMMUNODEFICIENCY VIRUS 1; MIRIDAE;

ALTERNATIVE SPLICING; BLOTTING, WESTERN; CARRIER PROTEINS; CELL LINE; GENE KNOCKDOWN TECHNIQUES; HUMANS; POLYMERASE CHAIN REACTION; PROTEIN ISOFORMS;

EID: 79960396329     PISSN: 0022538X     EISSN: 10985514     Source Type: Journal    
DOI: 10.1128/JVI.00648-11     Document Type: Article

References (51)

1. Battivelli, E., et al. 2010. Strain-specific differences in the impact of human TRIM5alpha, different TRIM5alpha alleles, and the inhibition of capsidcyclophilin A interactions on the infectivity of HIV-1. J. Virol. 84:11010-11019.
2. Berthoux, L., S. Sebastian, D. M. Sayah, and J. Luban. 2005. Disruption of human TRIM5alpha antiviral activity by nonhuman primate orthologues. J. Virol. 79:7883-7888.
3. Bock, M., K. N. Bishop, G. Towers, and J. P. Stoye. 2000. Use of a transient assay for studying the genetic determinants of Fv1 restriction. J. Virol. 74:7422-7430.
4. Brennan, G., Y. Kozyrev, T. Kodama, and S. L. Hu. 2007. Novel TRIM5 isoforms expressed by Macaca nemestrina. J. Virol. 81:12210-12217.
5. Carthagena, L., et al. 2008. Implication of TRIM alpha and TRIMCyp in interferon-induced anti-retroviral restriction activities. Retrovirology 5:59.
6. Chang, Y. F., J. S. Imam, and M. F. Wilkinson. 2007. The nonsense-mediated decay RNA surveillance pathway. Annu. Rev. Biochem. 76:51-74.
7. Diaz-Griffero, F., et al. 2007. Comparative requirements for the restriction of retrovirus infection by TRIM5alpha and TRIMCyp. Virology 369:400-410.
8. Diaz-Griffero, F., et al. 2007. Modulation of retroviral restriction and proteasome inhibitor-resistant turnover by changes in the TRIM5alpha B-box 2 domain. J. Virol. 81:10362-10378.
9. Diaz-Griffero, F., et al. 2006. Rapid turnover and polyubiquitylation of the retroviral restriction factor TRIM5. Virology 349:300-315.
10. Diaz-Griffero, F., et al. 2009. A B-box 2 surface patch important for TRIM5alpha self-association, capsid binding avidity, and retrovirus restriction. J. Virol. 83:10737-10751.
11. Goldschmidt, V., et al. 2006. Role of common human TRIM5alpha variants in HIV-1 disease progression. Retrovirology 3:54.
12. Hatziioannou, T., S. Cowan, U. K. Von Schwedler, W. I. Sundquist, and P. D. Bieniasz. 2004. Species-specific tropism determinants in the human immunodeficiency virus type 1 capsid. J. Virol. 78:6005-6012.
13. Hatziioannou, T., D. Perez-Caballero, S. Cowan, and P. D. Bieniasz. 2005. Cyclophilin interactions with incoming human immunodeficiency virus type 1 capsids with opposing effects on infectivity in human cells. J. Virol. 79: 176-183.
14. Javanbakht, H., et al. 2006. Effects of human TRIM5alpha polymorphisms on antiretroviral function and susceptibility to human immunodeficiency virus infection. Virology 354:15-27.
15. Javanbakht, H., F. Diaz-Griffero, M. Stremlau, Z. Si, and J. Sodroski. 2005. The contribution of RING and B-box 2 domains to retroviral restriction mediated by monkey TRIM5alpha. J. Biol. Chem. 280:26933-26940.
16. Javanbakht, H., et al. 2006. Characterization of TRIM5alpha trimerization and its contribution to human immunodeficiency virus capsid binding. Virology 353:234-246.
17. Keckesova, Z., L. M. Ylinen, and G. J. Towers. 2006. Cyclophilin A renders human immunodeficiency virus type 1 sensitive to Old World monkey but not human TRIM5 alpha antiviral activity. J. Virol. 80:4683-4690.
18. Keckesova, Z., L. M. Ylinen, and G. J. Towers. 2004. The human and African green monkey TRIM5alpha genes encode Ref1 and Lv1 retroviral restriction factor activities. Proc. Natl. Acad. Sci. U. S. A. 101:10780-10785.
19. Langelier, C. R., et al. 2008. Biochemical characterization of a recombinant TRIM5alpha protein that restricts human immunodeficiency virus type 1 replication. J. Virol. 82:11682-11694.
20. Li, X., and J. Sodroski. 2008. The TRIM5alpha B-box 2 domain promotes cooperative binding to the retroviral capsid by mediating higher-order selfassociation. J. Virol. 82:11495-11502.
21. Lin, L., et al. 2008. Diverse splicing patterns of exonized Alu elements in human tissues. PLoS Genet. 4:e1000225.
22. Luban, J. 2007. Cyclophilin A, TRIM5, and resistance to human immunodeficiency virus type 1 infection. J. Virol. 81:1054-1061.
23. Maegawa, H., E. E. Nakayama, A. Kuroishi, and T. Shioda. 2008. Silencing of tripartite motif protein (TRIM) 5alpha mediated anti-HIV-1 activity by truncated mutant of TRIM5alpha. J. Virol. Methods 151:249-256.
24. Maillard, P. V., G. Ecco, M. Ortiz, and D. Trono. 2010. The specificity of TRIM5 alpha-mediated restriction is influenced by its coiled-coil domain. J. Virol. 84:5790-5801.
25. Matsuoka, S., E. Dam, D. Lecossier, F. Clavel, and A. J. Hance. 2009. Modulation of HIV-1 infectivity and cyclophilin A-dependence by Gag sequence and target cell type. Retrovirology 6:21.
26. Mische, C. C., et al. 2005. Retroviral restriction factor TRIM5alpha is a trimer. J. Virol. 79:14446-14450.
27. Newman, R. M., and W. E. Johnson. 2007. A brief history of TRIM5alpha. AIDS Rev. 9:114-125.
28. Ohkura, S., M. W. Yap, T. Sheldon, and J. P. Stoye. 2006. All three variable regions of the TRIM5alpha B30.2 domain can contribute to the specificity of retrovirus restriction. J. Virol. 80:8554-8565.
29. Passerini, L. D., Z. Keckesova, and G. J. Towers. 2006. Retroviral restriction factors Fv1 and TRIM5alpha act independently and can compete for incoming virus before reverse transcription. J. Virol. 80:2100-2105.
30. Perez-Caballero, D., T. Hatziioannou, A. Yang, S. Cowan, and P. D. Bieniasz. 2005. Human tripartite motif 5alpha domains responsible for retrovirus restriction activity and specificity. J. Virol. 79:8969-8978.
31. Perron, M. J., et al. 2007. The human TRIM5alpha restriction factor mediates accelerated uncoating of the N-tropic murine leukemia virus capsid. J. Virol. 81:2138-2148.
32. Reymond, A., et al. 2001. The tripartite motif family identifies cell compartments. EMBO J. 20:2140-2151.
33. Saenz, D. T., W. Teo, J. C. Olsen, and E. M. Poeschla. 2005. Restriction of feline immunodeficiency virus by Ref1, Lv1, and primate TRIM5alpha proteins. J. Virol. 79:15175-15188.
34. Sakuma, R., A. A. Mael, and Y. Ikeda. 2007. Alpha interferon enhances TRIM5alpha-mediated antiviral activities in human and rhesus monkey cells. J. Virol. 81:10201-10206.
35. Sakuma, R., J. A. Noser, S. Ohmine, and Y. Ikeda. 2007. Rhesus monkey TRIM5alpha restricts HIV-1 production through rapid degradation of viral Gag polyproteins. Nat. Med. 13:631-635.
36. Sakuma, R., S. Ohmine, A. A. Mael, J. A. Noser, and Y. Ikeda. 2008. No effect of endogenous TRIM5alpha on HIV-1 production. Nat. Med. 14:236-238. (Author reply.)
37. Sawyer, S. L., L. I. Wu, J. M. Akey, M. Emerman, and H. S. Malik. 2006. High-frequency persistence of an impaired allele of the retroviral defense gene TRIM5alpha in humans. Curr. Biol. 16:95-100.
38. Sewram, S., et al. 2009. Human TRIM5alpha expression levels and reduced susceptibility to HIV-1 infection. J. Infect. Dis. 199:1657-1663.
39. Sokolskaja, E., L. Berthoux, and J. Luban. 2006. Cyclophilin A and TRIM5alpha independently regulate human immunodeficiency virus type 1 infectivity in human cells. J. Virol. 80:2855-2862.
40. Sorek, R., G. Ast, and D. Graur. 2002. Alu-containing exons are alternatively spliced. Genome Res. 12:1060-1067.
41. Stremlau, M., et al. 2004. The cytoplasmic body component TRIM5alpha restricts HIV-1 infection in Old World monkeys. Nature 427:848-853.
42. Stremlau, M., et al. 2006. Specific recognition and accelerated uncoating of retroviral capsids by the TRIM5alpha restriction factor. Proc. Natl. Acad. Sci. U. S. A. 103:5514-5519.
43. Stremlau, M., M. Perron, S. Welikala, and J. Sodroski. 2005. Species-specific variation in the B30.2(SPRY) domain of TRIM5alpha determines the potency of human immunodeficiency virus restriction. J. Virol. 79:3139-3145.
44. Stremlau, M., B. Song, H. Javanbakht, M. Perron, and J. Sodroski. 2006. Cyclophilin A: an auxiliary but not necessary cofactor for TRIM5alpha restriction of HIV-1. Virology 351:112-120.
45. Thierry-Mieg, D., and J. Thierry-Mieg. 2006. AceView: a comprehensive cDNA-supported gene and transcripts annotation. Genome Biol. 7(Suppl. 1):S12.1-14.
46. Towers, G. J. 2007. The control of viral infection by tripartite motif proteins and cyclophilin A. Retrovirology 4:40.
47. Venter, J. C., et al. 2001. The sequence of the human genome. Science 291:1304-1351.
48. Yap, M. W., S. Nisole, C. Lynch, and J. P. Stoye. 2004. Trim5alpha protein restricts both HIV-1 and murine leukemia virus. Proc. Natl. Acad. Sci. U. S. A. 101:10786-10791.
49. Zhang, F., T. Hatziioannou, D. Perez-Caballero, D. Derse, and P. D. Bieniasz. 2006. Antiretroviral potential of human tripartite motif-5 and related proteins. Virology 353:396-409.
50. Zhang, F., D. Perez-Caballero, T. Hatziioannou, and P. D. Bieniasz. 2008. No effect of endogenous TRIM5alpha on HIV-1 production. Nat. Med. 14:235-236.
51. Zhang, X., et al. 2010. Inhibitory effect of human TRIM5alpha on HIV-1 production. Microbes Infect. 12:768-777.