Behaviour of the motoneurone pool in a fatiguing submaximal contraction

Journal of Physiology

Volumn 589, Issue 14, 2011, Pages 3533-3544

  McNeil, Chris J ^a   Giesebrecht, Sabine ^a   Gandevia, Simon C ^a   Taylor, Janet L ^a  

^a UNIVERSITY OF NEW SOUTH WALES   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; ARTICLE; CONTROLLED STUDY; FEMALE; HUMAN; HUMAN EXPERIMENT; MALE; MOTONEURON; MOTOR CORTEX; MUSCLE CONTRACTION; MUSCLE FATIGUE; NERVE CELL EXCITABILITY; NERVE STIMULATION; NORMAL HUMAN; PRIORITY JOURNAL; SPINAL CORD MOTONEURON; STIMULUS RESPONSE;

ADULT; ELBOW JOINT; ELECTRIC STIMULATION; ELECTROMYOGRAPHY; EVOKED POTENTIALS, MOTOR; FEMALE; HUMANS; MALE; MOTOR CORTEX; MOTOR NEURONS; MUSCLE CONTRACTION; MUSCLE FATIGUE; MUSCLE, SKELETAL; TRANSCRANIAL MAGNETIC STIMULATION;

EID: 79960364324     PISSN: 00223751     EISSN: 14697793     Source Type: Journal    
DOI: 10.1113/jphysiol.2011.207191     Document Type: Article

References (40)

1. Benwell NM, Mastaglia FL & Thickbroom GW (2007). Differential changes in long-interval intracortical inhibition and silent period duration during fatiguing hand exercise. Exp Brain Res 179, 255-262.
2. Berardelli A, Inghilleri M, Rothwell JC, Cruccu G & Manfredi M (1991). Multiple firing of motoneurones is produced by cortical stimulation but not by direct activation of descending motor tracts. Electroencephalogr Clin Neurophysiol 81, 240-242.
3. Bigland-Ritchie BR, Dawson NJ, Johansson RS & Lippold OC (1986). Reflex origin for the slowing of motoneurone firing rates in fatigue of human voluntary contractions. J Physiol 379, 451-459.
4. Binder MD, Heckman CJ & Powers RK. (1996). The physiological control of motoneuron activity. In Handbook of Physiology, section 12, Exercise: Regulation and Integration of Multiple Systems, ed. Rowell LB & Shepherd JT, pp. 3-53. American Physiological Society, Bethesda, MD.
5. Borg G (1990). Psychophysical scaling with applications in physical work and the perception of exertion. Scand J Work Environ Health 16(Suppl 1), 55-58.
6. Butler JE, Taylor JL & Gandevia SC (2003). Responses of human motoneurons to corticospinal stimulation during maximal voluntary contractions and ischemia. J Neurosci 23, 10224-10230.
7. Carpentier A, Duchateau J & Hainaut K (2001). Motor unit behaviour and contractile changes during fatigue in the human first dorsal interosseus. J Physiol 534, 903-912.
8. Fuglevand AJ, Zackowski KM, Huey KA & Enoka RM (1993). Impairment of neuromuscular propagation during human fatiguing contractions at submaximal forces. J Physiol 460, 549-572.
9. Fuhr P, Agostino R & Hallett M (1991). Spinal motor neuron excitability during the silent period after cortical stimulation. Electroencephalogr Clin Neurophysiol 81, 257-262.
10. Gandevia SC (2001). Spinal and supraspinal factors in human muscle fatigue. Physiol Rev 81, 1725-1789.
11. Gandevia SC, Allen GM, Butler JE & Taylor JL (1996). Supraspinal factors in human muscle fatigue: evidence for suboptimal output from the motor cortex. J Physiol 490, 529-536.
12. Gandevia SC, Petersen N, Butler JE & Taylor JL (1999). Impaired response of human motoneurones to corticospinal stimulation after voluntary exercise. J Physiol 521, 749-759.
13. Hoffman BW, Oya T, Carroll TJ & Cresswell AG (2009). Increases in corticospinal responsiveness during a sustained submaximal plantar flexion. J Appl Physiol 107, 112-120.
14. Johnson KV, Edwards SC, Van Tongeren C & Bawa P (2004). Properties of human motor units after prolonged activity at a constant firing rate. Exp Brain Res 154, 479-487.
15. Kernell D & Monster AW (1982). Time course and properties of late adaptation in spinal motoneurones of the cat. Exp Brain Res 46, 191-196.
16. Kukulka CG & Clamann HP (1981). Comparison of the recruitment and discharge properties of motor units in human brachial biceps and adductor pollicis during isometric contractions. Brain Res 219, 45-55.
17. Lemon RN & Mantel GW (1989). The influence of changes in discharge frequency of corticospinal neurones on hand muscles in the monkey. J Physiol 413, 351-378.
18. Levenez M, Garland SJ, Klass M & Duchateau J (2008). Cortical and spinal modulation of antagonist coactivation during a submaximal fatiguing contraction in humans. J Neurophysiol 99, 554-563.
19. Lippold OCJ, Redfearn JWT & Vuco J (1960). The electromyography of fatigue. Ergonomics 3, 121-131.
20. Martin PG, Gandevia SC & Taylor JL (2006a). Output of human motoneuron pools to corticospinal inputs during voluntary contractions. J Neurophysiol 95, 3512-3518.
21. Martin PG, Smith JL, Butler JE, Gandevia SC & Taylor JL (2006b). Fatigue-sensitive afferents inhibit extensor but not flexor motoneurons in humans. J Neurosci 26, 4796-4802.
22. McKay WB, Stokic DS, Sherwood AM, Vrbova G & Dimitrijevic MR (1996). Effect of fatiguing maximal voluntary contraction on excitatory and inhibitory responses elicited by transcranial magnetic motor cortex stimulation. Muscle Nerve 19, 1017-1024.
23. McNeil CJ, Martin PG, Gandevia SC & Taylor JL (2009). The response to paired motor cortical stimuli is abolished at a spinal level during human muscle fatigue. J Physiol 587, 5601-5612.
24. McNeil CJ, Martin PG, Gandevia SC & Taylor JL (2011a). Long-interval intracortical inhibition in a human hand muscle. Exp Brain Res 209, 287-297.
25. McNeil CJ, Martin PG, Gandevia SC & Taylor JL (2011b). A novel way to test human motoneurone behaviour during muscle fatigue. Physiology News 82, 29-31.
26. Powers RK & Binder MD (2001). Input-output functions of mammalian motoneurons. Rev Physiol Biochem Pharmacol 143, 137-263.
27. Roick H, von Giesen HJ & Benecke R (1993). On the origin of the postexcitatory inhibition seen after transcranial magnetic brain stimulation in awake human subjects. Exp Brain Res 94, 489-498.
28. Rothwell JC (2009). The fatigued spinal cord. J Physiol 587, 5517-5518.
29. Sacco P, Newberry R, McFadden L, Brown T & McComas AJ (1997). Depression of human electromyographic activity by fatigue of a synergistic muscle. Muscle Nerve 20, 710-717.
30. Sawczuk A, Powers RK & Binder MD (1997). Contribution of outward currents to spike-frequency adaptation in hypoglossal motoneurons of the rat. J Neurophysiol 78, 2246-2253.
31. Smith JL, Martin PG, Gandevia SC & Taylor JL (2007). Sustained contraction at very low forces produces prominent supraspinal fatigue in human elbow flexor muscles. J Appl Physiol 103, 560-568.
32. Sogaard K, Gandevia SC, Todd G, Petersen NT & Taylor JL (2006). The effect of sustained low-intensity contractions on supraspinal fatigue in human elbow flexor muscles. J Physiol 573, 511-523.
33. Spielmann JM, Laouris Y, Nordstrom MA, Robinson GA, Reinking RM & Stuart DG (1993). Adaptation of cat motoneurons to sustained and intermittent extracellular activation. J Physiol 464, 75-120.
34. Taylor JL, Butler JE, Allen GM & Gandevia SC (1996). Changes in motor cortical excitability during human muscle fatigue. J Physiol 490, 519-528.
35. Taylor JL, Petersen N, Butler JE & Gandevia SC (2000). Ischaemia after exercise does not reduce responses of human motoneurones to cortical or corticospinal tract stimulation. J Physiol 525, 793-801.
36. Taylor JL, Petersen NT, Butler JE & Gandevia SC (2002). Interaction of transcranial magnetic stimulation and electrical transmastoid stimulation in human subjects. J Physiol 541, 949-958.
37. Ugawa Y, Rothwell JC, Day BL, Thompson PD & Marsden CD (1991). Percutaneous electrical stimulation of corticospinal pathways at the level of the pyramidal decussation in humans. Ann Neurol 29, 418-427.
38. Uncini A, Treviso M, Di Muzio A, Simone P & Pullman S (1993). Physiological basis of voluntary activity inhibition induced by transcranial cortical stimulation. Electroencephalogr Clin Neurophysiol 89, 211-220.
39. Valls-Sole J, Pascual-Leone A, Wassermann EM & Hallett M (1992). Human motor evoked responses to paired transcranial magnetic stimuli. Electroencephalogr Clin Neurophysiol 85, 355-364.
40. Ziemann U, Netz J, Szelenyi A & Homberg V (1993). Spinal and supraspinal mechanisms contribute to the silent period in the contracting soleus muscle after transcranial magnetic stimulation of human motor cortex. Neurosci Lett 156, 167-171.