Operational challenges in delivering CD4 diagnostics in sub-Saharan Africa

AIDS Care - Psychological and Socio-Medical Aspects of AIDS/HIV

Volumn 23, Issue 7, 2011, Pages 814-821

  Thairu, L ^a   Katzenstein, D ^a   Israelski, D ^b  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b Pangaea Global AIDS Foundation   (United States)

Author keywords

Burkina Faso; CD4 T cell enumeration; service delivery; Zimbabwe

Indexed keywords

ARTICLE; CD4 LYMPHOCYTE COUNT; CONTINUING EDUCATION; DIAGNOSTIC ERROR; DISEASE CLASSIFICATION; FLUORESCENCE ACTIVATED CELL SORTING; HEALTH CARE ACCESS; HEALTH CARE DELIVERY; HEALTH CARE QUALITY; HEALTH CARE UTILIZATION; HIV TEST; LABORATORY TEST; PRIORITY JOURNAL; PROFESSIONAL COMPETENCE; ZIMBABWE;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; BURKINA FASO; CD4 LYMPHOCYTE COUNT; CHILD; CHILD, PRESCHOOL; DIAGNOSTIC SERVICES; FEMALE; FLOW CYTOMETRY; HEALTH SERVICES ACCESSIBILITY; HIV INFECTIONS; HUMANS; INFANT; LABORATORIES; MALE; MIDDLE AGED; YOUNG ADULT; ZIMBABWE;

EID: 79960355377     PISSN: 09540121     EISSN: 13600451     Source Type: Journal    
DOI: 10.1080/09540121.2010.541416     Document Type: Article

References (23)

1. Birx, D., de Souza, M., & Nkengasong, J.N. (2009). Laboratory challenges in the scaling up of HIV, TB, and malaria programs: The interaction of health and laboratory systems, clinical research, and service delivery. American Journal of Clinical Pathology, 131, 849-851.
2. Bishaia, D., Colcheroa, A., & Durack, D.T. (2007). The cost effectiveness of antiretroviral treatment strategies in resource-limited settings. AIDS, 21, 1333-1340. (Pubitemid 46883488)
3. Department of Health and Human Services (DHHS). (2009, December 1). Panel on Antiretroviral Guidelines for Adults and Adolescents. Guidelines for the use of antiretroviral agents in HIV-1-infected adults and ado-lescents(pp. 1-61). Retrievedfromhttp://www.aidsinfo. nih.gov/ContentFiles/AdultandAdolescentGL.pdf
4. Gilks, C.F., behalf of the Development of AntiRetroviral Therapy (DART) trial team. (2009, July 19-22). Cost effectiveness analysis ofroutine laboratory or clinically driven strategies. DART trial 5th IAS conference on HIV pathogenesis, treatment and prevention, Cape Town, South Africa.
5. Granich, R.M. (2009, July 21). HAARTas HIVprevention. 5th IAS conference on HIV pathogenesis, treatment and prevention, Cape Town, South Africa.
6. Granich, R.M., Gilks, C.F., Dye, C., De Cock, K.M., & Williams, B.G. (2009). Universal voluntary HIV test-ing with immediate antiretroviral therapy as a strategy for elimination of HIV transmission: A mathematical model. Lancet, 373, 48-57.
7. TM assay for the enumeration of human CD4+ and CD8+ Tlymphocytes. Presented at the 2004 annual meeting of the Clinical Cytometry Society, Long Beach, California, USA.
8. Kantor, R., Diero, L., DeLong, A., Kamle, L., Muyonga, S., Mambo, F.,& Buziba, N. (2009). Misclassifica-tion of first-line antiretroviral treatment failure based on immunological monitoring of HIV infection in resource-limited settings. Clinical Infectious Diseases, 49, 454-462.
9. Kassaye, S.G., Ndayishimiye, F., Binswanger, H., Sall, A.Y., Machekano, R., & Israelski, D.M. (2006). Association-driven care and treatment: A model for community-based delivery of HIV/AIDS healthcare in resource-limited settings. AIDS, 20(11), 1561-1562. (Pubitemid 44100221)
10. Kitahata, M.M., Gange, S.J, Abraham, A.G., Merriman, B., Saag, M.S., Justice, A.C.,..Moore, R.D., for the NA-ACCORD Investigators. (2009). Effect of early versus deferred antiretroviral therapy for HIV on survival. New England Journal of Medicine, 360, 1815-1826.
11. MacLennan, C.A., Liu, M.K.P, White, S.A., van Oosterh-out, J.J.G., & Simukonda, F. (2007). Diagnostic accuracy and clinical utility of a simplified low cost method of counting CD4 cells with flow cytometry in Malawi: Diagnostic accuracy study. British Medical Journal, 335, 190-194. (Pubitemid 47218514)
12. Manasa, J., Musabaike, H., Masimirembwa, C., Burke, E., Luthy, R., & Mudzori, J. (2007). Evaluation of the Partec flow cytometer against the BD FACSCalibur System for monitoring immune responses of human immunodeficiency virus-infected patients in Zim-babwe. Clinical and Vaccine Immunology, 14(3), 293-298 (Pubitemid 46570287)
13. Mugyenyi, P. on behalf of the Development of AntiRetro-viral Therapy (DART) trial team. (2009, July 19-22). Comparison ofroutine versus clinically driven laboratory monitoring in HIV-1 infected African adults over 5 years on ART: Final results of the DART trial. 5th IAS conference on HIV pathogenesis, treatment and pre-vention, Cape Town, South Africa.
14. Pattanapanyasat, K., Phuang-Ngern, Y., Lerdwana, S., Wasinrapee, P., Sakulploy, N., Noulsri, E., McNi-choll, J.M. (2007). Evaluation of a single-platform microcapillary flow cytometer for enumeration of absolute CD41 T-Lymphocyte counts in HIV-1 in-fected Thai patients. Cytometry Part B (Clinical Cytometry), 72B, 387-396. (Pubitemid 350194356)
15. Peti, C.A., Polage, C.R., Quinn, T., Ronald, A.R., & Sande, M.A. (2006). Laboratory medicine in Africa: Barrier to effective health care. Clinical Infectious Diseases, 42, 377-382. (Pubitemid 43122314)
16. Rodriguez, W.A., Christodoulides, N., Floriano, P.N., Graham, S., Mohanty, S., Dixon, M., Bruce, D.W. (2005). A microchip CD4 counting method for HIV. Plos Medicine, 2(7), 663-672.
17. Thakar, M.R., Kumar, B.K., Mahajan, B.A., Mehendale, S.M., & Paranjape, R.S. (2006). Comparison of capillary based microflurometric assay for CD4+ T cell count estimation with dual platform Flow cyto-metry. AIDS Research and Therapy, 3, 26-32.
18. The Strategies for Management of Antiretroviral Therapy (SMART) Study Group. (2008). Major clinical out-comes in antiretroviral therapy (ART)-Naive partici-pants and in those not receiving ART at baseline in the SMART study. Journal of Infectious Diseases, 197, 1133-1144.
19. Thompson, M.A., Aberg, J.A., Cahn, P., et al. (2010). Antiretroviral treatment of adult HIV infection: 2010 recommendations of the International AIDS Society USA panel. JAMA, 304, 321-333.
20. UNAIDS. (2008). Report on the global AIDS epidemic. Geneva: Author.
21. United Nations. (2008). The millenium development goals report 2008. New York: Author.
22. WHO. (2006). Antiretroviral Therapy for HIV Infection in Adults and Adolescents: Recommendations for a Public Health Approach. Geneva: Author.
23. WHO. (2009). Rapidadvice: Antiretroviral therapy for HIV infection in adults and adolescents. Geneva: Author.