Anti-inflammatory and analgesic activities of Tunisian Citrullus colocynthis Schrad. immature fruit and seed organic extracts

European Review for Medical and Pharmacological Sciences

Volumn 15, Issue 6, 2011, Pages 665-672

  Marzouk, Belsem ^a   Marzouk, Z ^a   Fenina, N ^a   Bouraoui, A ^a   Aouni, M ^a  

^a UNIVERSITY OF MONASTIR   (Tunisia)

Author keywords

Analgesic; Anti inflammatory; Citrullus colocynthis Schrad.; Fruits; Seeds

Indexed keywords

ACETIC ACID ETHYL ESTER; ACETONE; CHLOROFORM; COLOCYNTH EXTRACT; METHANOL; PETROLEUM ETHER;

ANALGESIC ACTIVITY; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; COLOCYNTH; CONTROLLED STUDY; DRUG ISOLATION; FRUIT; MALE; MOUSE; NONHUMAN; PAIN; PAW EDEMA; PLANT SEED; RAT; WRITHING TEST;

ANALGESICS; ANIMALS; ANTI-INFLAMMATORY AGENTS; CITRULLUS; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; FRUIT; INFLAMMATION; MALE; MEDICINE, TRADITIONAL; MICE; PAIN; PLANT EXTRACTS; RATS; RATS, WISTAR; SEEDS; TUNISIA;

EID: 79960345576     PISSN: 11283602     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (22)

1. POTTIER-ALAPETITE G. Flore De La Tunisie. Angiospermes- Dicotylédones: Gamopétales. Ed. Imprimerie officielle de la république tunisienne, Tunis, Tunisia; 1981.
2. BOUKEF MK. Médecine traditionnelle et pharmacopée. Les plantes dans la médecine traditionnelle tunisienne. Ed. Agence de coopération culturelle et technique, Paris; 1986.
3. LE FLOCK E. Contribution à une étude ethnobotanique de la flore tunisienne. Ed. Imprimerie officielle de la république tunisienne, Tunis, Tunisia; 1983.
4. MOHAND AIT Y. Plantes médicinales et Kabylies. Ibis press, Paris; 2006.
5. BELLAKHDHAR J. La pharmacopée marocaine traditionnelle. Ibis press, Paris; 1999.
6. EL-GHADI A, BSHANA S. Usage of plants in Libyan folk-medicine, first part. Dar Elkotob Elwataniya; 1988.
7. TANNIN-SPITZ T, GROSSMAN S, DOVRAT S, GROTTLIEB HE, BERGMAN M. Growth inhibitory activity of cucurbitacin glucosides isolated from Citrullus colocynthis on human breast cancer cells. Biochem Pharmacol 2007; 73: 56-67.
8. BENDJEDDOU D, LALAOUI K, SATTA D. Immunostimulating activity of the hot water soluble polysaccharide extracts of Anacyclus pyrethrum, Alpinia galangal and Citrullus colocynthis. J Ethnopharmacol 2003; 88: 155-160.
9. MARZOUK B, MARZOUK Z, DÉCOR R, EDZIRI H, HALOUI E, FENINA N, AOUNI M. Antibacterial and anticandidal screening of Tunisian Citrullus colocynthis Schrad. from Medenine. J Ethnopharmacol 2009; 125: 344-349.
10. MARZOUK B, MARZOUK Z, DÉCOR R, MHADHBI L, FENINA N, AOUNI M. Antibacterial and anticandidal activities of several populations of Tunisian Citrullus colocynthis Schrad. immature fruits and seeds. J Med Mycol 2010; in press.
11. MARZOUK Z, MARZOUK B, MAHJOUB MA, HALOUI E, MIGHRI Z, AOUNI M, FENINA N. Screening of the antioxidant and the free radical scavenging potential of Tunisian Citrullus colocynthis Schrad. from Medenine. J Food Agric Environ 2010; 8:261-265.
12. GEBHARDT R. Antioxidative, antiproliferative and biochemical effects in Hep G2 cells of a homeopathic remedy and its constituent plant tinctures tested separately or in combination. Arzneimittelforschung 2003; 53: 823-830.
13. AL-GAITHI F, EL-DIRI MR, ADEGHATE E, AMIRI MH. Biochemical effects of Citrullus colocynthis in normal and diabetic rats. Mol Cell Biochem 2004; 261: 143-149.
14. ROY RK, THAKUR M, DIXIT VK. Development and evaluation of polyherbal formulation for hair growth-promoting activity. J Cosm Dermatol 2007; 6: 108-112.
15. MARZOUK B, MARZOUK Z, HALOUI E, FENINA N, BOURAOUI A, AOUNI M. Screening of analgesic and anti-inflammatory activities of Citrullus colocynthis from southern Tunisia. J Ethnopharmacol 2010; 128: 15-19.
16. KOSTER R, ANDERSON M, DE BEER EJ. Acetic acid for analgesic screening. Fed Proc 1959; 18: 418-420.
17. WINTER CA, RISLEY EA, Nuss GW. Carrageenan induced edema hind paw of the rat as an essay for anti-inflammatory drugs. Proc Soc Exper Biol Med 1962; 3: 544-547.
18. COLLIER HO, DINNEEN LC, JOHNSON CA SCHNEIDER C. The abdominal construction response and its suppression by analgesic drugs in the mouse. Br J Pharmacol 1968; 32: 295-310.
19. DUARTE IDG, NAKAMURA M, FERREIRA SH. Participation of the sympathetic system in acetic acid-induced writhing in mice. Bras J Med Biol Res 1988; 21: 341-343.
20. JOHN H, NODINE MD. Chicago: Year Book Medical Publishers INC; 1999.
21. OLAJIDE OA, MAKINDE MJ, AWE SO. Effects of the aqueous extract of Bridelia ferruginea stem bark on carrageenan-induced oedema and granuloma tissue formation in rats and mice. J Ethnopharmacol 1999; 66: 113-117.
22. MOULIN M, COQUEREL A. Pharmacologie, connaissance et pratique. Masson, Paris; 2002.