A novel GLP-1 analog exhibits potent utility in the treatment of type 2 diabetes with an extended half-life and efficient glucose clearance in vivo

Peptides

Volumn 32, Issue 7, 2011, Pages 1408-1414

  Li, Ying ^a,c   Xu, Weiren ^b   Tang, Lida ^b   Gong, Min ^a,b   Zhang, Jianning ^c  

^a UNIVERSITY OF BIRMINGHAM   (United Kingdom)

^b TIANJIN INSTITUTE OF PHARMACEUTICAL RESEARCH   (China)

^c TIANJIN MEDICAL UNIVERSITY   (China)

Author keywords

Disulfide bond; HbA1c; Insulin stimulation; Long acting GLP 1 analogs; Tryptophan cage

Indexed keywords

ANTIDIABETIC AGENT; GLUCAGON LIKE PEPTIDE 1 DERIVATIVE; GLUCAGON LIKE PEPTIDE 1 RECEPTOR; GLUCAGON LIKE PEPTIDE 715A; GLUCOSE; HEMOGLOBIN A1C; INSULIN; LONG ACTING DRUG; TRYPTOPHAN; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; DRUG HALF LIFE; GLUCOSE TOLERANCE; IN VIVO STUDY; INSULIN RELEASE; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; PHYSIOLOGY; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN STABILITY; RAT; RECEPTOR BINDING; SINGLE DRUG DOSE; WILD TYPE;

AMINO ACID SEQUENCE; ANIMALS; BLOOD GLUCOSE; DIABETES MELLITUS, TYPE 2; DIPEPTIDYL PEPTIDASE 4; DRUG DESIGN; DRUG STABILITY; GLUCAGON-LIKE PEPTIDE 1; GLUCOSE TOLERANCE TEST; HALF-LIFE; HEMOGLOBIN A, GLYCOSYLATED; HUMANS; HYPOGLYCEMIC AGENTS; INSULIN; KINETICS; MALE; MOLECULAR SEQUENCE DATA; PROTEIN BINDING; RATS; RATS, SPRAGUE-DAWLEY; RATS, ZUCKER; RECEPTORS, GLUCAGON; SERUM; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION; TRYPTOPHAN;

ANIMALIA; RODENTIA;

EID: 79960316076     PISSN: 01969781     EISSN: 18735169     Source Type: Journal    
DOI: 10.1016/j.peptides.2011.05.026     Document Type: Article

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