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0037776876
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Glucagon-like peptides
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Amylin Pharmaceuticals files IND for AC-2993 (synthetic exendin-4); Reports on feasibility of non-injectable routes of delivery
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0026648961
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Isolation and characterization of exendin-4, an exendin-3 analog from Heloderma suspectum venom
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Once daily injection of exendin-4 to diabetic mice achieves long-term beneficial effects on blood glucose concentrations
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Influence of glucagon-like peptide 1 on fasting glucose glycemia in type 2 diabetic patients treated with insulin after sulfonylurea secondary failure
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Dipeptidyl peptidase IV resistant analogues of glucagon-like peptide-1 which have extended metabolic stability and improved biological activity
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0001030412
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Comparison of the glucose-lowering effects of exendin-4 and GLP-1 in diabetic db/db mice
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315208 Comparison of the glucose-lowering effects of exendin-4 and GLP-1 in diabetic db/db mice. Bhavasar SP, Watkins JJ, Young AA Diabetes 1998 47 Suppl 1 746
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25544454917
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Dose-response for glucose lowering by exendin-4 in diabetic rhesus monkeys (Macaca mulatta)
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315209 Dose-response for glucose lowering by exendin-4 in diabetic rhesus monkeys (Macaca mulatta). Bodkin N, Hansen B, Young AA Diabetes 1998 47 Suppl 1 361
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0000379749
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Exendin-4 decreases hemoglobin A1c in diabetic fatty Zucker rats
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315210 Exendin-4 decreases hemoglobin A1c in diabetic fatty Zucker rats. Gedulin BR, Jodka C, Hoyt JA, Lawler R, Young AA Diabetes 1998 47 Suppl 1 1085
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American Diabetes Association - 59th Annual Meeting San Diego, CA, USA
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329671 American Diabetes Association - 59th Annual Meeting San Diego, CA, USA. Hopfner R IDDB Meeting Report 1999 June 19-22
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IDDB Meeting Report 1999 June 19-22
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23
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0038453768
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Amylin Pharmaceuticals acquires patent rights for exendin-4 gene
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337550; August 23
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337550 Amylin Pharmaceuticals acquires patent rights for exendin-4 gene. Amylin Pharmaceuticals Inc Press Release 1999 August 23
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24
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0032908654
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Glucose-lowering and insulin-sensitizing actions of exendin-4: Studies in obese diabetic (ob/ob, db/db) mice, diabetic fatty Zucker rats, and diabetic rhesus monkeys (Macaca mulatta)
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344745; note
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344745 Glucose-lowering and insulin-sensitizing actions of exendin-4: Studies in obese diabetic (ob/ob, db/db) mice, diabetic fatty Zucker rats, and diabetic rhesus monkeys (Macaca mulatta). Young AA, Gedulin BR, Bhavsar S, Bodkin N, Jodka C, Hansen B, Denaro M Diabetes 1999 48 5 1026-1034 A preclinical study which compares the effects of GLP-1 and exendin-4 in several animal models of diabetes.
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0038114413
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Product Pipeline: AC2993
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352024 Product Pipeline: AC2993. Amylin Pharmaceuticals Inc Company World Wide Web Site 2000 January 11
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(2000)
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0038453764
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Amylin Pharmaceuticals and Alkermes sign agreement for development of long-acting formulation of AC2993 (synthetic exendin-4)
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366516; May 15
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366516 Amylin Pharmaceuticals and Alkermes sign agreement for development of long-acting formulation of AC2993 (synthetic exendin-4). Amylin Pharmaceuticals Inc Press Release 2000 May 15
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(2000)
Amylin Pharmaceuticals Inc Press Release
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0000181936
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Effects of five-day dosing of synthetic exendin-4 (AC2993) in people with type 2 diabetes
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369298; Abs 402-P
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28
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0000181936
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Dose-response for postprandial glucose-lowering effect of synthetic exendin-4 (AC2993) in subject with type 2 diabetes
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369579; Abs 427-P
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369579 Dose-response for postprandial glucose-lowering effect of synthetic exendin-4 (AC2993) in subject with type 2 diabetes. Fineman M, Young A, Gaines E, Prickett K Diabetes 2000 49 Suppl 1 Abs 427-P
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Dose-response for inhibition of glucagon secretion and gastric emptying by synthetic exendin-4 (AC2993) in subjects with type 2 diabetes
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Hypoglycemic override of inhibition of gastric emptying by exendin-4
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Amylin Pharmaceuticals initiates phase II study of diabetes drug candidate AC2993 in type II diabetes to support start of phase III in 2001
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388319; November 02
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388319 Amylin Pharmaceuticals initiates phase II study of diabetes drug candidate AC2993 in type II diabetes to support start of phase III in 2001. Amylin Pharmaceuticals Inc Press Release 2000 November 02
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0037776875
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JP Morgan Hambrecht & Quist 19th Annual Healthcare Conference (Part IV) San Francisco, CA, USA
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Amylin Pharmaceuticals obtains license from NIH for novel use of exendin-4
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402351 Amylin Pharmaceuticals obtains license from NIH for novel use of exendin-4. Amylin Pharmaceuticals Inc Press Release 2001 March 19
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0034602252
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Sustained expression of exendin-4 does not perturb glucose homeostasis, β-cell mass, or food intake in metallothionein-preproexendin transgenic mice
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408388 Sustained expression of exendin-4 does not perturb glucose homeostasis, β-cell mass, or food intake in metallothionein-preproexendin transgenic mice. Baggio L, Adatia F, Bock T, Brubaker PL, Drucker DJ J Biol Chem 2000 275 44 34471-3447
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0034456212
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Exendin-4 decelerates food intake, weight gain, and fat deposition in Zucker rats
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408391 Exendin-4 decelerates food intake, weight gain, and fat deposition in Zucker rats. Szayna M, Doyle ME, Betkey JA, Holloway HW, Spencer RG, Greig NH, Egan JM Endocrinology 2000 141 6 1936-1941
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Glucagon-like peptide 1 and exendin-4 convert pancreatic AR42J cells into glucagon- and insulin-producing cells
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408397 Glucagon-like peptide 1 and exendin-4 convert pancreatic AR42J cells into glucagon- and insulin-producing cells. Zhou J, Wang X, Pineyro MA, Egan JM Diabetes 1999 48 12 2358-2366
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0033513455
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Exendin-4 stimulates both β-cell replication and neogenesis, resulting in increased β-cell mass and improved glucose tolerance in diabetic rats
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408400
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408400 Exendin-4 stimulates both β-cell replication and neogenesis, resulting in increased β-cell mass and improved glucose tolerance in diabetic rats. Xu G, Stoffers DA, Habener JF, Bonner-Weir S Diabetes 1999 48 12 2270-2276
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0038114400
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Amylin Pharmaceuticals presents positive results from AC2993 (synthetic exendin-4) one-month study in type II diabetes at American Diabetes Association Annual Meeting
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413370; June 22
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413370 Amylin Pharmaceuticals presents positive results from AC2993 (synthetic exendin-4) one-month study in type II diabetes at American Diabetes Association Annual Meeting. Amylin Pharmaceuticals Inc Press Release 2001 June 22
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(2001)
Amylin Pharmaceuticals Inc Press Release
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0038188375
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American Diabetes Association - 61st Scientific Sessions (Part V), Philadelphia, PA, USA
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413888 American Diabetes Association - 61st Scientific Sessions (Part V), Philadelphia, PA, USA. Patterson C IDDB Meeting Report 2001 June 22-26
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IDDB Meeting Report 2001 June 22-26
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Patterson, C.1
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0038114412
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Novo Nordisk development pipeline, updated quarterly
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414671 Novo Nordisk development pipeline, updated quarterly. Company World Wide Web Site July 06 2001
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(2001)
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0037776908
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American Diabetes Association - 61st Scientific Sessions (Part VI), Philadelphia, PA, USA
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415122 American Diabetes Association - 61st Scientific Sessions (Part VI), Philadelphia, PA, USA. Hopfner R IDDB Meeting Report 2001 June 22-26
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IDDB Meeting Report 2001 June 22-26
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Hopfner, R.1
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0038791393
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Amylin Pharmaceuticals announces two abstracts accepted by American Society for Clinical Pharmacology and Therapeutics for 2002 annual meeting
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432359; December 05
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432359 Amylin Pharmaceuticals announces two abstracts accepted by American Society for Clinical Pharmacology and Therapeutics for 2002 annual meeting. Amylin Pharmaceuticals Inc Press Release 2001 December 05
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(2001)
Amylin Pharmaceuticals Inc Press Release
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43
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0038791394
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Amylin Pharmaceuticals initiates first phase 3 pivotal trial of AC2993 (synthetic exendin-4) in type 2 diabetes
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432922; December 10
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432922 Amylin Pharmaceuticals initiates first phase 3 pivotal trial of AC2993 (synthetic exendin-4) in type 2 diabetes. Amylin Pharmaceuticals Inc Press Release 2001 December 10
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(2001)
Amylin Pharmaceuticals Inc Press Release
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0038453759
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Zealand Pharmaceuticals in clinical trials with anti-diabetic
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434384; December 20
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434384 Zealand Pharmaceuticals in clinical trials with anti-diabetic. Zealand Pharmaceuticals Press Release 2001 December 20
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(2001)
Zealand Pharmaceuticals Press Release
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0038453760
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Amylin Pharmaceuticals initiates second phase III pivotal trial of AC2993 (synthetic exendin-4) in type II diabetes
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437942; January 30
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437942 Amylin Pharmaceuticals initiates second phase III pivotal trial of AC2993 (synthetic exendin-4) in type II diabetes. Amylin Pharmaceuticals Inc Press Release 2002 January 30
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(2002)
Amylin Pharmaceuticals Inc Press Release
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0038453758
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Amylin Pharmaceuticals initiates third phase III pivotal trial of AC2993 (synthetic exendin-4) in type II diabetes
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443501; March 14
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443501 Amylin Pharmaceuticals initiates third phase III pivotal trial of AC2993 (synthetic exendin-4) in type II diabetes. Amylin Pharmaceuticals Inc Press Release 2002 March 14
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(2002)
Amylin Pharmaceuticals Inc Press Release
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0038453750
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Amylin Pharmaceuticals: Uniquely positioned with two late-stage, first-in-class diabetes product candidates
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443509; February 26
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443509 Amylin Pharmaceuticals: Uniquely positioned with two late-stage, first-in-class diabetes product candidates. Amylin Pharmaceuticals Inc Company Presentation 2002 February 26
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(2002)
Amylin Pharmaceuticals Inc Company Presentation
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48
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0242472310
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ConjuChem announces start of phase I trial for DAC:GLP-1, a type II diabetes drug candidate
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457323; July 08
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457323 ConjuChem announces start of phase I trial for DAC:GLP-1, a type II diabetes drug candidate. ConjuChem Inc Press Release 2002 July 08
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(2002)
ConjuChem Inc Press Release
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49
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0038791433
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European Association for the Study of Diabetes - 38th Annual Meeting (Part II), Budapest, Hungary
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464652
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464652 European Association for the Study of Diabetes - 38th Annual Meeting (Part II), Budapest, Hungary. Van Der Wal PS IDDB Meeting Report 2002 September 1-5
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IDDB Meeting Report 2002 September 1-5
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Van Der Wal, P.S.1
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50
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0038114406
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Lilly and Amylin to collaborate on potential breakthrough diabetes treatment
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464704; September 20
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464704 Lilly and Amylin to collaborate on potential breakthrough diabetes treatment. Eli Lilly & Co, Amylin Pharmaceuticals Inc Press Release 2002 September 20
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(2002)
Eli Lilly & Co, Amylin Pharmaceuticals Inc Press Release
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0037776869
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Theratechnologies expands peptide portfolio in endocrinology with the addition of a GLP-1 program for the treatment of type II diabetes
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465091; September 25
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465091 Theratechnologies expands peptide portfolio in endocrinology with the addition of a GLP-1 program for the treatment of type II diabetes. Theratechnologies Inc Press Release 2002 September 25
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(2002)
Theratechnologies Inc Press Release
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0038791387
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Amylin and Lilly announce completion of enrollment for first phase III pivotal trial of AC2993 (synthetic Exendin-4) in type II diabetes
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