Molecular targets for retinal diseases: Hypoxia-regulated genes play an important role in vascular permeability and neovascularization

Retina Today

Volumn , Issue AUGUST-SUPPL., 2010, Pages 4-7

  Campochiaro, Peter A ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 79960315051     PISSN: None     EISSN: 18250572     Source Type: Journal    
DOI: None     Document Type: Article

References (10)

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2. Saishin Y, Saishin Y, Takahashi J, et al. VEGF-TRAP R1RS suppresses choroidal neovascularization and VEGF-induced breakdown of the blood-retinal barrier. J Cell Physiol. 2003;195:241-248.
3. Seo M-S, Okamoto N, Vinores MA, et al. Photoreceptor specific expression of platederived growth factor-B results in traction retinal detachment. Am J Pathol. 2000;995-1005.
4. Seo M-S, Kwak NH, Ozaki H, et al. Dramatic inhibition of retinal and choroidal neovascularization by oral administration of a kinase inhibitor. Am J Pathol. 1999;154:1743-1753.
5. Takahashi K, Saishin Y, Saishin T, et al. The multi-targeted kinase inhibitor pazopanib causes suppression and regression of choroidal neovascularization. Arch Ophthalmol. 2009;127:494-499.
6. Lima e Silva R, Shen J, Hackett S, et al. The SDF-1/CXCR4 ligand/receptor pair is an important contributor to several types of ocular neovascularization. FASEB J. 2007;21:3219-3230.
7. Zhang H, Qian DZ, Tan YS, et al. Digoxin and other cardiac glycosides inhibit HIF-1a synthesis and block tumor growth. Proc Natl Acad Sci USA. 2008;105:19579-19586.
8. Yoshida T, Zhang H, Iwase I, et al. Digoxin inhibits retinal ischemia-induced HIF-1a expression and ocular neovascularization. FASEB J. 2010;24:1759-1767.
9. Nguyen QD, Shah MS, Van Anden E, Sung JU, Vitale S, Campochiaro PA. Supplemental oxygen improves diabetic macular edema: a pilot study. Invest Ophthalmol Vis Sci. 2004;45:617-624.
10. Ozaki H, Hayashi H, Vinores SA, et al. Intravitreal sustained release of VEGF causes retinal neovascularization in rabbits and breakdown of the blood-retinal barrier in rabbits and primates. Eye Expert Res. 1997;64:505-517.