The N-terminal region of the porcine epidemic diarrhea virus spike protein is important for the receptor binding

Korean Journal of Microbiology and Biotechnology

Volumn 39, Issue 2, 2011, Pages 140-145

  Lee, Dong Kyu ^a   Cha, Se Yeoun ^b   Lee, Changhee ^a  

^a Kyungpook National University   (South Korea)

^b Chonbuk National University   (South Korea)

Author keywords

pAPN; Porcine epidemic diarrhea virus (PEDV); Receptor binding domain; Spike protein

Indexed keywords

CELL RECEPTOR; MICROSOMAL AMINOPEPTIDASE; VIRUS SPIKE PROTEIN;

AMINO TERMINAL SEQUENCE; ARTICLE; BINDING AFFINITY; CELL STRAIN HEK293; CONTROLLED STUDY; HUMAN; HUMAN CELL; INFECTIOUS DIARRHEA; MOLECULAR RECOGNITION; NONHUMAN; NUCLEOTIDE SEQUENCE; PIGLET; PORCINE EPIDEMIC DIARRHEA VIRUS; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION; RECEPTOR AFFINITY; RECEPTOR BINDING; RECEPTOR BINDING DOMAIN; SWINE DISEASE; TARGET CELL; VIRUS ATTACHMENT; WESTERN BLOTTING;

CORONAVIRUS; PORCINE EPIDEMIC DIARRHEA VIRUS; SUS;

EID: 79960294842     PISSN: 1598642X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (21)

1. Bonavia, A., B. D. Zelus, D. E. Wentworth, P. J. Talbot, and K. V. Holmes. 2002. Identification of a receptor-binding domain of the spike glycoprotein of human Coronavirus HCoV-229E. J. Virol. 77: 530-538.
2. Bosch, B. J., R. Van Der Zee, C. A. De Haan, and P. J. Rottier. 2003. The Coronavirus spike protein is a class I virus fusion protein: structural and functional characterization of the fusion core complex. J. Virol. 77: 8801-8811.
3. Delmas, B., J. Gelfi, R. L'Haridon, L. K. Vogel, H. Sjöström, O. Norén, and H. Laude. 1992. Aminopeptidase N is a major receptor for the entero-pathogenic Coronavirus TGEV. Nature 357: 417-420.
4. Farzan M., T. Mirzabekov, P. Kolchinsky, R. Wyatt, M. Cayabyab, N. P. Gerard, C. Gerard, J. Sodroski, and H. Choe. 1999. Tyrosine sulfation of the amino terminus of CCR5 facilitates HIV-1 entry. Cell 96: 667-676. (Pubitemid 29122809)
5. Gallagher, T. M. and M. J. Buchmeier. 2001. Coronavirus spike proteins in viral entry and pathogenesis. Virology 279: 371-374.
6. Godet, M., J. Grosclaude, B. Delmas, and H. Laude. 1994. Major receptor-binding and neutralization determinants are located within the same domain of the transmissible gastroenteritis virus (Coronavirus) spike protein. J. Virol. 68: 8008-8016.
7. Kolb, A. F., A. Hegyi, J. Maile, A. Heister, M. Hagemann, and S. G. Siddell. 1998. Molecular analysis of the coronavirus-receptor function of aminopeptidase N. Adv. Exp. Med. Biol. 440: 61-67.
8. Kubo, H., Y. K. Yamada, and F. Taguchi. 1994. Localization of neutralizing epitopes and the receptor-binding site within the amino-terminal 330 amino acids of the murine coronavirus spike protein. J. Virol. 68: 403-410.
9. Lai, C. C., M. J. Jou, S. Y. Huang, S. W. Li, L. Wan, F. J. Tsai, and C. W. Lin. 2007. Proteomic analysis of up-regulated proteins in human promonocyte cells expressing severe acute respiratory syndrome Coronavirus 3C-like protease. Proteomics 7: 1446-1460
10. Laude, H., M. Godet, S. Bernard, J. Gelfi, M. Duarte, and B. Delmas. 1995. Functional domains in the spike protein of transmissible gastroenteritis virus. Adv. Exp. Med. Biol. 380: 299-304.
11. Lee, C., J. G. Calvert, S. K. Welch, and D. Yoo. 2005. A DNA-launched reverse genetics system for porcine reproductive and respiratory syndrome virus reveals that homodimerization of the nucleocapsid protein is essential for virus infectivity. Virology 331: 47-62. (Pubitemid 39593632)
12. Lee, D. K., C. K. Park, S. H. Kim, and C. Lee. 2010. Heterogeneity in spike protein genes of porcine epidemic diarrhea viruses isolated in Korea. Virus Res. 149: 175-182.
13. Lee, Y. J., C. K. Park, E. Nam, S. H. Kim, O. S. Lee, D. S. Lee, and C. Lee. 2010. Generation of a porcine alveolar macrophage cell line for the growth of porcine reproductive and respiratory syndrome virus. J. Virol. Methods 163: 410-415.
14. Li, B. X., J. W. Ge, and Y J. Li. 2007. Porcine aminopeptidase N is a functional receptor for the PEDV Coronavirus. Virology 365: 166-172. (Pubitemid 46907229)
15. Li, W., M. J. Moore, N. Vasilieva, J. Sui, S. K. Wong, M. A. Berne, M. Somasundaran, J. L. Sullivan, K. Luzuriaga, T. C. Greenough, H. Choe, and M. Farzan. 2003. Angiotensin-converting enzyme 2 is a functional receptor for the SARS Coronavirus. Nature 426: 450-454. (Pubitemid 37490132)
16. Lin, H. X., Y. Feng, G. Wong, L. Wang, B. Li, X. Zhao, Y. Li, F. Smaill, and C. Zhang. 2007. Identification of residues in the receptor-binding domain (RBD) of the spike protein of human coronavirus NL63 that are critical for the RBD-ACE2 receptor interaction. J. Gen. Virol. 89: 1015-1024.
17. Nam, E. and C. Lee. 2010. Contribution of the porcine aminopeptidase N (CD 13) receptor density to porcine epidemic diarrhea virus infection. Vet. Microbiol. 144: 41-50.
18. Pensaert, M. B. and S. G. Yeo. 2006. Porcine epidemic diarrhea, pp. 367-372. In B. E. Straw, J. J. Zimmerman, S. D'Allaire, and D. J. Taylor (ed.), Diseases of Swine, 9th ed. Wiley-Blackwell, Ames.
19. Tresnan D. B., R. Levis, and K. V. Holmes. 1996. Feline aminopeptidase N serves as a receptor for feline, canine, porcine, and human coronaviruses in serogroup I. J. Virol. 70: 669-674.
20. Wong S. K., W. Li, M. J. Moore, H. Choe, and M. Farzan. 2004. A 193-amino acid fragment of the SARS Coronavirus S protein efficiently binds angiotensin-converting enzyme 2. J. Biol. Chem. 279: 3197-3201.
21. Yeager, C. L., R. A. Ashmun, R. K. Williams, C. B. Cardellichio, L. H. Shapiro, A. T. Look, and K. V. Holmes. 1992. Human aminopeptidase N is a receptor for human coronavirus 229E. Nature 357: 420-422.