Novel antihypertensive hexa- and heptapeptides with ACE-inhibiting properties: From the in vitro ACE assay to the spontaneously hypertensive rat

Peptides

Volumn 32, Issue 7, 2011, Pages 1431-1438

  Ruiz Giménez, Pedro ^a   Marcos, José F ^a   Torregrosa, Germán ^b,c   Lahoz, Agustín ^d   Fernández Musoles, Ricardo ^a   Valles, Salvador ^a   Alborch, Enrique ^b,c   Manzanares, Paloma ^a   Salom, Juan B ^b,c  

^a INSTITUTO DE AGROQUÍMICA Y TECNOLOGÍA DE ALIMENTOS CSIC   (Spain)

^b HOSPITAL UNIVERSITARIO LA FE   (Spain)

^c UNIVERSITY OF VALENCIA   (Spain)

^d INSTITUTO DE INVESTIGACIÓN SANITARIA DEL HOSPITAL CLÍNICO SAN CARLOS IDISSC   (Spain)

Author keywords

ACE inhibitor; Angiotensin converting enzyme; Antihypertensive peptide; Hypertension; Spontaneously hypertensive rat; Vasoconstriction

Indexed keywords

CAPTOPRIL; DIPEPTIDYL CARBOXYPEPTIDASE; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; HEPTAPEPTIDE; HEXAPEPTIDE; PROLYLALANYLCYSTEINYLGLUTAMIC ACID 132; PROLYLALANYLCYSTEINYLGLUTAMIC ACID 134; PROLYLALANYLCYSTEINYLGLUTAMIC ACID 148; PROLYLALANYLCYSTEINYLGLUTAMIC ACID 149; PROLYLALANYLCYSTEINYLGLUTAMIC ACID 150; PROLYLALANYLCYSTEINYLGLUTAMIC ACID 151; PROLYLALANYLCYSTEINYLGLUTAMIC ACID 152; PROLYLALANYLCYSTEINYLGLUTAMIC ACID 153; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIHYPERTENSIVE ACTIVITY; ARTICLE; CELL ASSAY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG DESIGN; DRUG EFFECT; DRUG POTENCY; DRUG SCREENING; ENZYME ACTIVITY; ENZYME ASSAY; EX VIVO STUDY; HYPERTENSION; IN VITRO STUDY; MALE; MEAN ARTERIAL PRESSURE; NONHUMAN; PRIORITY JOURNAL; RAT; SYSTOLIC BLOOD PRESSURE; VASOCONSTRICTION;

RATTUS;

EID: 79960289733     PISSN: 01969781     EISSN: 18735169     Source Type: Journal    
DOI: 10.1016/j.peptides.2011.05.013     Document Type: Article

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