Steroid dependency and pediatric inflammatory bowel disease in the era of immunomodulators - A population-based study

Inflammatory Bowel Diseases

Volumn 17, Issue 8, 2011, Pages 1731-1740

  Jakobsen, Christian ^a   Munkholm, Pia ^b   Paerregaard, Anders ^a   Wewer, Vibeke ^a  

^a HVIDOVRE HOSPITAL   (Denmark)

^b GENTOFTE UNIVERSITY HOSPITAL   (Denmark)

Author keywords

corticosteroids; immunosuppressive therapy; inflammatory bowel disease; surgery

Indexed keywords

AZATHIOPRINE; CYCLOSPORIN; IMMUNOMODULATING AGENT; INFLIXIMAB; MERCAPTOPURINE; MESALAZINE; METHOTREXATE; STEROID;

ADD ON THERAPY; ADOLESCENT; ARTICLE; CHILD; CONTROLLED STUDY; CROHN DISEASE; DENMARK; FEMALE; FOLLOW UP; HUMAN; INFANT; MAJOR CLINICAL STUDY; MALE; NEWBORN; POPULATION RESEARCH; PRESCHOOL CHILD; PRIORITY JOURNAL; RELAPSE; REMISSION; SCHOOL CHILD; SHORT COURSE THERAPY; STEROID THERAPY; SURGICAL RISK; SYSTEMIC THERAPY; TREATMENT RESPONSE; ULCERATIVE COLITIS;

6-MERCAPTOPURINE; ADOLESCENT; ADRENAL CORTEX HORMONES; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; AZATHIOPRINE; CHILD; CHILD, PRESCHOOL; COLITIS, ULCERATIVE; CROHN DISEASE; DENMARK; FEMALE; FOLLOW-UP STUDIES; HUMANS; IMMUNOSUPPRESSIVE AGENTS; INFANT; MALE; MESALAMINE; REMISSION INDUCTION; TIME FACTORS; TREATMENT OUTCOME;

EID: 79960280229     PISSN: 10780998     EISSN: 15364844     Source Type: Journal    
DOI: 10.1002/ibd.21559     Document Type: Article

References (24)

1. Munkholm P, Langholz E, Davidsen M, et al. Frequency of glucocorticoid resistance and dependency in Crohn's disease. Gut. 1994; 35: 360-362.
2. Chebli JM, Gaburri PD, De Souza AF, et al. Long-term results with azathioprine therapy in patients with corticosteroid-dependent Crohn's disease: open-label prospective study. J Gastroenterol Hepatol. 2007; 22: 268-274. (Pubitemid 46181359)
3. Faubion WA Jr, Loftus EV Jr, Harmsen WS, et al. The natural history of corticosteroid therapy for inflammatory bowel disease: a population-based study. Gastroenterology. 2001; 121: 255-260. (Pubitemid 32729372)
4. Ho GT, Chiam P, Drummond H, et al. The efficacy of corticosteroid therapy in inflammatory bowel disease: analysis of a 5-year UK inception cohort. Aliment Pharmacol Ther. 2006; 24: 319-330. (Pubitemid 43972900)
5. Gower-Rousseau C, Dauchet L, Vernier-Massouille G, et al. The natural history of pediatric ulcerative colitis: a population-based cohort study. Am J Gastroenterol. 2009; 104: 2080-2088.
6. Tung J, Loftus EV Jr, Freese DK, et al. A population-based study of the frequency of corticosteroid resistance and dependence in pediatric patients with Crohn's disease and ulcerative colitis. Inflamm Bowel Dis. 2006; 12: 1093-1100. (Pubitemid 44847465)
7. Vernier-Massouille G, Balde M, Salleron J, et al. Natural history of pediatric Crohn's disease: a population-based cohort study. Gastroenterology. 2008; 135: 1106-1113.
8. Langholz E., Ulcerative colitis. An epidemiological study based on a regional inception cohort, with special reference to disease course and prognosis. Dan Med Bull. 1999; 46: 400-415.
9. Munkholm P., Crohn's disease-occurrence, course and prognosis. An epidemiologic cohort-study. Dan Med Bull. 1997; 44: 287-302. (Pubitemid 27293419)
10. Peyrin-Biroulet L, Loftus EV Jr, Colombel JF, et al. The natural history of adult Crohn's disease in population-based cohorts. Am J Gastroenterol. 2010; 105: 289-297.
11. Tarrant KM, Barclay ML, Frampton CM, et al. Perianal disease predicts changes in Crohn's disease phenotype-results of a population-based study of inflammatory bowel disease phenotype. Am J Gastroenterol. 2008; 103: 3082-3093.
12. Langholz E, Munkholm P, Krasilnikoff PA, et al. Inflammatory bowel diseases with onset in childhood. Clinical features, morbidity, and mortality in a regional cohort. Scand J Gastroenterol. 1997; 32: 139-147. (Pubitemid 27075119)
13. Cosnes J, Nion-Larmurier I, Beaugerie L, et al. Impact of the increasing use of immunosuppressants in Crohn's disease on the need for intestinal surgery. Gut. 2005; 54: 237-241. (Pubitemid 40139240)
14. D'Haens G, Baert F, van Assche G, et al. Early combined immunosuppression or conventional management in patients with newly diagnosed Crohn's disease: an open randomised trial. Lancet. 2008; 371: 660-667. (Pubitemid 351284485)
15. http://www.statistikbanken.dk. 2009.
16. Vind I, Riis L, Jess T, et al. Increasing incidences of inflammatory bowel disease and decreasing surgery rates in Copenhagen City and County, 2003-2005: a population-based study from the Danish Crohn colitis database. Am J Gastroenterol. 2006; 101: 1274-1282. (Pubitemid 43833122)
17. Silverberg MS, Satsangi J, Ahmad T, et al. Toward an integrated clinical, molecular and serological classification of inflammatory bowel disease: report of a Working Party of the 2005 Montreal World Congress of Gastroenterology. Can J Gastroenterol. 2005; 19 (suppl A): 5-36.
18. Romberg-Camps MJ, Dagnelie PC, Kester AD, et al. Influence of phenotype at diagnosis and of other potential prognostic factors on the course of inflammatory bowel disease. Am J Gastroenterol. 2009; 104: 371-383.
19. D'Agostino RB Jr., Propensity score methods for bias reduction in the comparison of a treatment to a non-randomized control group. Stat Med. 1998; 17: 2265-2281. (Pubitemid 28466823)
20. Langholz E., Ulcerative colitis. An epidemiological study based on a regional inception cohort, with special reference to disease course and prognosis. Dan Med Bull. 1999; 46: 400-415.
21. Munkholm P., Crohn's disease-occurrence, course and prognosis. An epidemiologic cohort-study. Dan Med Bull. 1997; 44: 287-302. (Pubitemid 27293419)
22. Kraemer HC., Events per person-time (incidence rate): a misleading statistic ? Stat Med. 2009; 28: 1028-1039.
23. Lin DY, Wei LJ., The robust inference for the Cox proportional hazards model. J Am Stat Assoc. 1989; 84: 1074-1078.
24. Jakobsen C, Paerregaard A, Munkholm P, et al. Paediatric inflammatory bowel disease during a 44-year period in Copenhagen County: occurrence, course and prognosis-a population-based study from the Danish Crohn Colitis Database. Eur J Gastroenterol Hepatol. 2009; 21: 1291-1301.