Intrathecal application of donor lymphocytes in leukemic meningeosis after allogeneic stem cell transplantation

Annals of Hematology

Volumn 90, Issue 8, 2011, Pages 911-916

  Neumann, Martin ^a   Blau, Igor W ^a   Burmeister, Thomas ^a   Tietze Buerger, Carola ^a   Blau, Olga ^a   Gerbitz, Armin ^a   Uharek, Lutz ^a   Thiel, Eckhard ^a  

^a CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

Author keywords

Adoptive cell therapy; CNS; DLI; Extramedullary relapse; Intrathecal; Leukemic meningeosis

Indexed keywords

BUSULFAN; CD14 ANTIGEN; CYCLOSPORIN; CYTARABINE; DEXAMETHASONE; FLUDARABINE; IMATINIB; MELPHALAN; METHOTREXATE; NILOTINIB; TREOSULFAN;

ACUTE GRANULOCYTIC LEUKEMIA; ADULT; ALLOGENEIC HEMATOPOIETIC STEM CELL TRANSPLANTATION; ARTICLE; BRAIN EDEMA; CANCER MORTALITY; CANCER RELAPSE; CASE REPORT; CEREBROSPINAL FLUID CYTOLOGY; CHRONIC MYELOID LEUKEMIA; COMPUTER ASSISTED TOMOGRAPHY; CYTAPHERESIS; DONOR LYMPHOCYTE INFUSION; DRUG MEGADOSE; FLOW CYTOMETRY; GRAFT VERSUS HOST REACTION; HUMAN; LEUKEMIC MENINGITIS; LUMBAR PUNCTURE; MALE; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; UNSPECIFIED SIDE EFFECT; WHOLE BODY RADIATION;

ADOLESCENT; ADULT; CENTRAL NERVOUS SYSTEM NEOPLASMS; CEREBROSPINAL FLUID; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HUMANS; INJECTIONS, SPINAL; LEUKEMIA, MYELOGENOUS, CHRONIC, BCR-ABL POSITIVE; LEUKEMIA, MYELOID, ACUTE; LYMPHOCYTE TRANSFUSION; MALE; TRANSPLANTATION, HOMOLOGOUS; TREATMENT OUTCOME;

EID: 79960258079     PISSN: 09395555     EISSN: 14320584     Source Type: Journal    
DOI: 10.1007/s00277-011-1171-x     Document Type: Article

References (21)

1. WY Au YL Kwong AK Lie SK Ma R Liang 1999 Extra-medullary relapse of leukemia following allogeneic bone marrow transplantation Hematol Oncol 17 45 52 10521868 10.1002/(SICI)1099-1069(199906)17:2<45::AID-HON641>3.0.CO;2-6 1:STN:280:DyaK1Mvlt1yjsQ%3D%3D (Pubitemid 29502312)
2. SA Giralt RE Champlin 1994 Leukemia relapse after allogeneic bone marrow transplantation: a review Blood 84 3603 3612 7949117 1:CAS:528: DyaK2MXisVGjtrk%3D (Pubitemid 24362455)
3. JH Lee SJ Choi JH Lee M Seol YS Lee SG Ryu CJ Park HS Chi MS Lee S Yun JS Lee KH Lee 2005 Anti-leukemic effect of graft-versus-host disease on bone marrow and extramedullary relapses in acute leukemia Haematologica 90 1380 1388 16219575 (Pubitemid 41503654)
4. JK Davies DC Taussig H Oakervee AJ Davies SG Agrawal JG Gribben TA Lister JD Cavenagh 2006 Long-term follow-up after reduced-intensity conditioning allogeneic transplantation for acute myeloid leukemia/myelodysplastic syndrome: late CNS relapses despite graft-versus-host disease J Clin Oncol 24 e23 e25 16682729 10.1200/JCO.2006.05.7281
5. S Seo M Kami H Honda T Kashima T Matsumura A Moriya U Machida Y Kanda S Chiba H Hirai 2000 Extramedullary relapse in the so-called 'sanctuary' sites for chemotherapy after donor lymphocyte infusion Bone Marrow Transplant 25 226 227 10673689 10.1038/sj.bmt.1702116 1:STN:280:DC%2BD3c7jvFenuw%3D%3D (Pubitemid 30088000)
6. SL Goldberg KF Mangan TR Klumpp TM Cropper SF Schnall JS Macdonald 1994 Lack of a graft-versus-leukemia effect in an immunologically privileged sanctuary site Bone Marrow Transplant 14 180 181 7951116 1:STN:280: DyaK2M%2FjvVKjtg%3D%3D (Pubitemid 24228765)
7. SJ Choi JH Lee JH Lee S Kim M Seol YS Lee JS Lee WK Kim HS Chi KH Lee 2004 Treatment of relapsed acute myeloid leukemia after allogeneic bone marrow transplantation with chemotherapy followed by G-CSF-primed donor leukocyte infusion: a high incidence of isolated extramedullary relapse Leukemia 18 1789 1797 15385924 10.1038/sj.leu.2403523 1:CAS:528:DC%2BD2cXovVGiur8%3D (Pubitemid 39530008)
8. C Berthou MC Leglise A Herry D Balcon E Hardy M Lessard JF Abgrall 1998 Extramedullary relapse after favorable molecular response to donor leukocyte infusions for recurring acute leukemia Leukemia 12 1676 1681 9823940 10.1038/sj.leu.2401144 1:STN:280:DyaK1M%2FjvFGntA%3D%3D (Pubitemid 28502484)
9. MG Donelli M Zucchetti M D'Incalci 1992 Do anticancer agents reach the tumor target in the human brain? Cancer Chemother Pharmacol 30 251 260 1643692 10.1007/BF00686291 1:STN:280:DyaK38zlsVWjtQ%3D%3D
10. ER Gerstner RL Fine 2007 Increased permeability of the blood-brain barrier to chemotherapy in metastatic brain tumors: establishing a treatment paradigm J Clin Oncol 25 2306 2312 17538177 10.1200/JCO.2006.10.0677 (Pubitemid 46954659)
11. AN Bekassy J Hermans NC Gorin A Gratwohl 1996 Granulocytic sarcoma after allogeneic bone marrow transplantation: a retrospective European multicenter survey. Acute and chronic leukemia working parties of the European group for blood and marrow transplantation Bone Marrow Transplant 17 801 808 8733701 1:STN:280:DyaK28zhtl2ksQ%3D%3D (Pubitemid 26156317)
12. Beillard E, Pallisgaard N, van dV, V, Bi W, Dee R, van der SE, Delabesse E, Macintyre E, Gottardi E, Saglio G, Watzinger F, Lion T, van Dongen JJ, Hokland P, Gabert J (2003) Evaluation of candidate control genes for diagnosis and residual disease detection in leukemic patients using 'real-time' quantitative reverse-transcriptase polymerase chain reaction (RQ-PCR)-a Europe against cancer program. Leukemia 17:2474-2486 (Pubitemid 38072587)
13. IW Blau M Schmidt-Hieber N Leschinger H Goldner W Knauf W Hopfenmuller E Thiel O Blau 2007 Engraftment kinetics and hematopoietic chimerism after reduced-intensity conditioning with fludarabine and treosulfan before allogeneic stem cell transplantation Ann Hematol 86 583 589 17468869 10.1007/s00277-007- 0294-6 1:CAS:528:DC%2BD2sXmvVKnur0%3D (Pubitemid 47022827)
14. N Meuleman I Ahmad H Duvillier M Lemort J Bennani M Martiat L Lagneaux D Bron 2006 Intrathecal donor lymphocyte infusion for the treatment of suspected refractory lymphomatous meningitis: a case report Eur J Haematol 77 523 526 17042768 10.1111/j.0902-4441.2006.t01-1-EJH2498.x 1:STN:280: DC%2BD28nmvFSgsQ%3D%3D (Pubitemid 44690799)
15. Thiel E, Blau IW, Neumann M, Tietze-Bürger C, Gerbitz A, Uharek L (2008) Treatment of leukemic meningeosis by CD14 depleted adoptive intrathecal cell therapy [abstract]. Blood 112.
16. A Saiz F Graus 2004 Neurological complications of hematopoietic cell transplantation Semin Neurol 24 427 434 15637654 10.1055/s-2004-861537 (Pubitemid 40076119)
17. CS Padovan K Bise J Hahn P Sostak E Holler HJ Kolb A Straube 1999 Angiitis of the central nervous system after allogeneic bone marrow transplantation? Stroke 30 1651 1656 10436117 10.1161/01.STR.30.8.1651 1:STN:280:DyaK1MzmsFCmuw%3D%3D (Pubitemid 29379619)
18. CS Padovan A Gerbitz P Sostak E Holler JL Ferrara K Bise A Straube 2001 Cerebral involvement in graft-versus-host disease after murine bone marrow transplantation Neurology 56 1106 1108 11320189 1:STN:280:DC%2BD3M3jtFCqtA%3D%3D (Pubitemid 32336324)
19. B Engelhardt RM Ransohoff 2005 The ins and outs of T-lymphocyte trafficking to the CNS: anatomical sites and molecular mechanisms Trends Immunol 26 485 495 16039904 10.1016/j.it.2005.07.004 1:CAS:528:DC%2BD2MXos1ahtbg%3D (Pubitemid 41139258)
20. E Pedemonte G Mancardi D Giunti A Corcione F Benvenuto V Pistoia A Uccelli 2006 Mechanisms of the adaptive immune response inside the central nervous system during inflammatory and autoimmune diseases Pharmacol Ther 111 555 566 16442633 10.1016/j.pharmthera.2005.11.007 1:CAS:528:DC%2BD28Xns1Sksrk%3D (Pubitemid 44118430)
21. TO Kleine L Benes 2006 Immune surveillance of the human central nervous system (CNS): different migration pathways of immune cells through the blood-brain barrier and blood-cerebrospinal fluid barrier in healthy persons Cytom A 69 147 151 10.1002/cyto.a.20225