Pga26 mediates filamentation and biofilm formation and is required for virulence in Candida albicans

FEMS Yeast Research

Volumn 11, Issue 5, 2011, Pages 389-397

  Laforet, Leslie ^a   Moreno, Inmaculada ^a   Sánchez Fresneda, Ruth ^b   Martínez Esparza, María ^c   Martínez, José P ^a   Argüelles, Juan Carlos ^b   De Groot, Piet W J ^d   Valentín Gomez, Eulogio ^a  

^a UNIVERSITY OF VALENCIA   (Spain)

^b UNIVERSITY OF MURCIA   (Spain)

^c UNIVERSITY OF MURCIA   (Spain)

^d UNIVERSITY OF CASTILLA LA MANCHA   (Spain)

Author keywords

Biofilm; Candida albicans; Cell wall; Filamentation; PGA26; Virulence

Indexed keywords

AMPHOTERICIN B; BETA 1,3 GLUCAN; CALCOFLUOR WHITE; CASPOFUNGIN; CELL ENZYME; CELL MEMBRANE PROTEIN; CONGO RED; DYE; FLUCONAZOLE; MANNOPROTEIN; PGA26 PROTEIN; POSACONAZOLE; UNCLASSIFIED DRUG; ZYMOLYASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIFUNGAL SUSCEPTIBILITY; ARTICLE; BIOFILM; CANDIDA ALBICANS; CARBOHYDRATE SYNTHESIS; CELL MEMBRANE; CELL WALL; CONTROLLED STUDY; FEMALE; FILAMENTATION; FUNGAL MORPHOLOGY; FUNGAL PHENOMENA AND FUNCTIONS; FUNGAL VIRULENCE; GENE DELETION; GENE DISRUPTION; GENE SWITCHING; HEAT STRESS; INVASIVE CANDIDIASIS; MOUSE; NONHUMAN; OSMOTIC STRESS; OXIDATIVE STRESS;

ANIMALS; ANTIFUNGAL AGENTS; BETA-GLUCANS; BIOFILMS; CANDIDA ALBICANS; CANDIDIASIS; CELL MEMBRANE; CELL WALL; ECHINOCANDINS; FEMALE; FUNGAL PROTEINS; GLYCOSYLPHOSPHATIDYLINOSITOLS; HUMANS; HYPHAE; IMMUNOLOGIC FACTORS; MICE; MODELS, ANIMAL; SEQUENCE DELETION; STRESS, PHYSIOLOGICAL; VIRULENCE;

CANDIDA; CANDIDA ALBICANS;

EID: 79960252744     PISSN: 15671356     EISSN: 15671364     Source Type: Journal    
DOI: 10.1111/j.1567-1364.2011.00727.x     Document Type: Article

References (35)

1. Alvarez-Peral FJ, Zaragoza O, Pedreño Y & Argüelles JC (2002) Protective role of trehalose during severe oxidative stress caused by hydrogen peroxide and the adaptive oxidative stress response in Candida albicans. Microbiology 148: 2599-2606.
2. Backen AC, Broadbent ID, Fetherston RW, Rosamond JD, Schnell NF & Stark MJ (2000) Evaluation of the CaMAL2 promoter for regulated expression of genes in Candida albicans. Yeast 16: 1121-1129.
3. Calderone RA & Fonzi WA (2001) Virulence factors of Candida albicans. Trends Microbiol 9: 327-335.
4. Casadevall A (2007) Determinants of virulence in the pathogenic fungi. Fungal Biol Rev 21: 130-132.
5. Castillo L, Martínez AI, Garcerá A, García-Martínez J, Ruiz-Herrera J, Valentín E & Sentandreu R (2006) Genomic response programs of Candida albicans following protoplasting and regeneration. Fungal Genet Biol 43: 124-134.
6. Castillo L, Calvo E, Martinez AI, Ruiz-Herrera J, Valentin E, Lopez JA & Sentandreu R (2008) A study of the Candida albicans cell wall proteome. Proteomics 8: 3871-3881.
7. Chauhan N, Latgé JP & Calderone R (2006) Signalling and oxidant adaptation in Candida albicans and Aspergillus fumigatus. Nat Rev Microbiol 4: 435-444.
8. Clinical and Laboratory Standards Institute (2008) Reference method for broth dilution antifungal susceptibility testing of yeast; approved standard. CLSI M27-A3, 3rd edn. Clinical and Laboratory Standards Institute, Wayne, PA.
9. De Boer AD, De Groot PWJ, Weindl G et al. (2010) The Candida albicans cell wall protein Rhd3/Pga29 is abundant in the yeast form and contributes to virulence. Yeast 27: 611-624.
10. Dijkgraaf GJP, Brown JL & Bussey H (1996) The KNH1 gene of Saccharomyces cerevisiae is a functional homolog of KRE9. Yeast 12: 683-692.
11. Fonzi WA & Irwin MY (1993) Isogenic strain construction and gene mapping in Candida albicans. Genetics 134: 717-728.
12. Garcia-Sanchez S, Aubert S, Iraqui I, Janbon G, Ghigo JM & d'Enfert C (2004) Candida albicans biofilms: a developmental state associated with specific and stable gene expression patterns. Eukaryot Cell 3: 536-545.
13. Hoyer LL, Green CB, Oh SH & Zhao X (2008) Discovering the secrets of the Candida albicans agglutinin-like sequence (ALS) gene family - a sticky pursuit. Med Mycol 46: 1-15.
14. Kapteyn JC, Hoyer LL, Hecht JE et al. (2000) The cell wall architecture of Candida albicans wild-type cells and cell wall-defective mutants. Mol Microbiol 35: 601-611.
15. Klis FM, Sosinska GJ, de Groot PWJ & Brul S (2009) Covalently linked cell wall proteins of Candida albicans and their role in fitness and virulence. FEMS Yeast Res 9: 1013-1028.
16. Lee KL, Buckley HR & Campbell CC (1975) An amino acid liquid synthetic medium for the development of mycelial and yeast forms of Candida albicans. Sabouraudia 13: 148-153.
17. Lesage G & Bussey H (2006) Cell wall assembly in Saccharomyces cerevisiae. Microbiol Mol Biol R 70: 317-343.
18. Lo HJ, Köhler JR, DiDomenico B, Loebenberg D, Cacciapuoti A & Fink GR (1997) Nonfilamentous C. albicans mutants are avirulent. Cell 90: 939-949.
19. Moreno I, Pedreño Y, Maicas S, Sentandreu R, Herrero E & Valentin E (2003) Characterization of a Candida albicans gene encoding a putative transcriptional factor required for cell wall integrity. FEMS Microbiol Lett 226: 159-167.
20. Moreno I, Martinez-Esparza M, Laforet LC, Sentandreu R, Ernst JF & Valentin E (2010) Dosage-dependent roles of the Cwt1 transcription factor for cell wall architecture, morphogenesis, drug sensitivity and virulence in Candida albicans. Yeast 27: 77-87.
21. Moreno-Ruiz E, Ortu G, De Groot PWJ et al. (2009) The GPI-modified proteins Pga59 and Pga62 of Candida albicans are required for cell wall integrity. Microbiology 155: 2004-2020.
22. Murad AMA, Lee PR, Broadbent ID, Barelle CJ & Brown AJ (2000) CIp10, an efficient and convenient integrating vector for Candida albicans. Yeast 16: 325-327.
23. Murad AMA, Leng P, Straffon M et al. (2001) NRG1 represses yeast-hypha morphogenesis and hypha-specific gene expression in Candida albicans. EMBO J 20: 4742-4752.
24. Nantel A, Dignard D, Bachewich C et al. (2002) Transcription profiling of Candida albicans cells undergoing the yeast-to-hyphal transition. Mol Biol Cell 13: 3452-3465.
25. Nett J, Lincoln L, Marchillo K et al. (2007) Putative role of b-1, 3 glucans in Candida albicans biofilm resistance. Antimicrob Agents Ch 51: 510-520.
26. O'Toole GA, Pratt LA, Watnick PI, Newman DK, Weaver VB & Kolter R (1999) Genetic approaches to study of biofilms. Method Enzymol 310: 91-109.
27. Pedreño Y, Maicas S, Arguelles JC, Sentandreu R & Valentin E (2004) The ATC1 gene encodes a cell wall-linked acid trehalase required for growth on trehalose in Candida albicans. J Biol Chem 279: 40852-40860.
28. Pérez A, Pedrós B, Murgui A, Casanova M, López-Ribot JL & Martínez JP (2006) Biofilm formation by Candida albicans mutants for genes coding fungal proteins exhibiting the eight-cysteine-containing CFEM domain. FEMS Yeast Res 6: 1074-1084.
29. Pérez A, Ramage G, Blanes R, Murgui A, Casanova M & Martinez JP (2011) Some biological features of Candida albicans mutants for genes coding fungal proteins containing the CFEM domain. FEMS Yeast Res, in press. DOI: DOI: 10.1111/j.1567-1364.2010.00714.x.
30. Pfaller MA & Diekema DJ (2010) Epidemiology of invasive mycoses in North America. Crit Rev Microbiol 36: 1-53.
31. Plaine A, Walker L, Da Costa G et al. (2008) Functional analysis of Candida albicans GPI-anchored proteins: roles in cell wall integrity and caspofungin sensitivity. Fungal Genet Biol 45: 1404-1414.
32. Richard ML & Plaine A (2007) Comprehensive analysis of glycosylphosphatidylinositol-anchored proteins in Candida albicans. Eukaryot Cell 6: 119-133.
33. Ruiz-Herrera J, Elorza MV, Valentin E & Sentandreu R (2006) Molecular organization of the cell wall of Candida albicans and its relation to pathogenicity. FEMS Yeast Res 6: 14-29.
34. Stoldt VR, Sonneborn A, Leuker CE & Ernst JF (1997) Efg1p, an essential regulator of morphogenesis of the human pathogen Candida albicans, is a member of a conserved class of bHLH proteins regulating morphogenetic processes in fungi. EMBO J 16: 1982-1991.
35. Sudbery P, Gow N & Berman J (2004) The distinct morphogenic states of Candida albicans. Trends Microbiol 12: 317-324.