Teratogenic and embryotoxic effects of clomiphene citrate in developing mice

Asian-Australasian Journal of Animal Sciences

Volumn 24, Issue 8, 2011, Pages 1053-1059

  Ara, Chaman ^a   Asmatullah, ^a  

^a UNIVERSITY OF THE PUNJAB   (Pakistan)

Author keywords

Clomiphene citrate; Embryotoxicity; Mice development; Teratogenicity

Indexed keywords

MUS;

EID: 79960244571     PISSN: 10112367     EISSN: None     Source Type: Journal    
DOI: 10.5713/ajas.2011.10392     Document Type: Article

References (31)

1. Adashi, E. Y. 1993. Clomiphene citrate: the case of monoisomeric preparations. Baillieres. Clin. Obstet. Gynaecol. 7:331-347. (Pubitemid 23217368)
2. Aker, H. and O. M. Bulay. 1985. Three Neon et al Ca Taract Cases produced in rats with clomiphene citrate. J. Med. Bes. 3(2): 185-188.
3. Alatas, C., E. Aksoy, B. Cenglz and M. Bahceci. 1995. Clomiphene citrate and phocomelia. Arch. Genaecol. Obstet. 256(1):33-34.
4. Arriaga-Alba, M., R. Flores-Paz, R. Diaz-Hernandez and M. E. Gonzalez-Patino. 2001. Assesssment of genetic toxicity of the exposure of clomiphene citrate, with various bacterial test systems. Teratog. Carcing. Mutagen. 21(3):213-221.
5. Asch, R. H. and R. B. Greenblatt. 1976. Update on the safety and efficacy of clomiphene citrate as a therapeutic agent. J. Reprod. Med. 17(3):175-180.
6. Banhidy, F., N. Acs and A. E. Czeizel. 2008. Ovarian cysts, clomiphene therapy and the risk of neural tube defects. Int. J. Obstet. Genecol. 100(1):86-88. (Pubitemid 350216883)
7. Bernstein, H. N. 1970. Some tatrogenic ocular diseases from systemically administered drugs. Int. Ophthalmol. Clin. 10: 553-618.
8. Brackett, N. L., M. Abae, O. D. Padron and C. M. Lynne. 1995. Treatment by assisted conception of severe male factor infertility due to spinal cord injury or other neurologic impairment. J. Assist. Reprod. Genet. 12(3):210-216.
9. Casper, R. E. 2007. Aromatase inhibitors in ovarian stimulation. Steriod. Biochem. Mol. Biol. 106(1-5):71-75.
10. Clark, J. H. and B. M. Markaverich. 1982. The agonistic-antagonistic properties of clomiphene: a review. Pharmacol. Therapeut. 15:467-519. (Pubitemid 12054890)
11. Csemiczky, G., J. Harlin and G. Fried. 2002. Predictive power of clomiphene citrate challenge test for failure of in vitro fertilization treatment. Acta. Obstet. Gynecol. Scand. 81(10): 954-961. (Pubitemid 35176988)
12. CSGN. 2006. http:/www.csgnetwork.com/glossary.html#calculator
13. Deveci, E., H. S. Inalöz, S. S. Inalöz and B. Unal. 2000. Effect of clomiphene citrate on neonatal rat skin. Clin. Exp. Obstel. Gynecol. 27(3-4):238-240. (Pubitemid 32141630)
14. Dickey, R. P. and D. E. Holtkamp. 1996. Development, pharmacology and clinical experience with clomiphene citrate. Hum. Reprod. Update. 2(6):483-506. (Pubitemid 27153988)
15. Duncan, D. B. 1955. Multiple range and multiple F tests. Biometrics 11:1-42.
16. Dziadek, M. 2005. Preovulatory administration of clomiphene citrate to mice causes fetal growth retardation and neural tube defects (exencephaly) by an indirects maternal effect. Exp. Teratol. 47(4):263-273.
17. Elizur, S. E. and T. Tulandi. 2008. Drugs in fertility and fetal safety. Fertil. Steril. 89(6):1595-1602.
18. ESHRE Capri Workshop Group, 1995. Anovulatory infertility. Hum. Reprod. 10:1549-1553.
19. Haring, D. A. J. P., M. C. Cornel, J. C. Van der Linden, J. M. G. Van Vugt and M. L. Kwee. 2005. Acardius acephalus after induced ovulation: a case report. Clin. Teratol. 47(4):257-262.
20. Harmon, J. R., W. S. Branham and D. M. Sheehan. 2005. Transplacental estrogen responses in the fetal rat: Increased uterine weight and ornithine decarboxylase activity. Dev. Pharmacol. Toxicol. 39(3):253-260.
21. Kennedy, J. L. and E. Y. Adashi. 1987. Ovulation induction. Obstet. Gynecol. Clin. North Am. 14(4):831-864. (Pubitemid 18097722)
22. Lerner- Geva, L., L. Keinan-Boker, T. Blumstein, V. Boyko, L. Olmar, S. Mashiac, J. Rabinovici, G. Potashnick, E. Lunenfeld, J. G. Schenker, A. Shushan, A. Fishman, I. Cohen, I. Vagman and B. Lunenfeld. 2006. Infertility, ovulation induction treatments and the incidence of breast cancer-A historical prospective cohort of Israeli Women. Breast Cancer Res. Treat. 100(2):201-212. (Pubitemid 44631922)
23. Macklon, N. S., R. L. Stoufer, L. C. Giudice and B. C. J. M. Fauser. 2006. The science behind 25 years of ovarian stimulationfor in vitro fertilization. Endocr. Rev. 27(2):170-207.
24. Martikainen, H., L. Ronnberg, A. Roukonen and A. Kauppila. 2006. Effect of clomiphene citrate on prolactin and gonadotropin release during GnRH- analog treatment. Theriogenology 66(6-7):1560-1567.
25. Mckenna, M. and R. J. Pepperell. 1988. Anti-oestrogens. Obstel. Gynaecol. 2:545-561.
26. Morris, J. M. 1970. Postcoital antifertility agents and their teratogenic effects. Contraception 2:85-97.
27. Motta, C. M. and J. S. Hutchinson. 1991. Effects of clomiphene citrate on early pregnancy in guinea pigs. J. Reprod. Fertil. 92: 65-73.
28. Orgeas, C. C., K. Sanner, P. Hall, P. Conner, J. Holte, S. J. Nilson, K. Sundfeldt, I. Persson, K. S. Chia, S. Wedron, P. W. Dickman and K. Czene. 2009. Breast cancer incident after hormonal treatment of infertility in Sweden: a cohort study. Am. J. Obstel. Gynecol. 200(1):72-77.
29. Plourde, P. V., H. E. Kulin and S. J. Santner. 1983. Clomiphene in treatment of adolescent gynacomastia: Clinical and endocrine studies. Am. J. Dis. Child. 137(11):1080-1082. (Pubitemid 13021594)
30. Randal, J. M. and A. Templeton. 1991. The effects of clomiphene citrate upon ovulation and endocrinology when administered to patients with unexplained infertility. Hum. Reprod. 6(5):659-664.
31. Schardein, J. L. 1980. Congenital abnormalities and harmones during pregnancy: A clinical review. Clin. Teratol. 22(3):251-270. (Pubitemid 11209782)