microRNA-450a targets DNA methyltransferase 3a in hepatocellular carcinoma

Experimental and Therapeutic Medicine

Volumn 2, Issue 5, 2011, Pages 951-955

  Weng, Zhihong ^a   Wang, Dongdong ^b   Zhao, Wenyue ^b   Song, Mengqi ^b   You, Faping ^b   Yang, Lian ^b   Chen, Libo ^b  

^a HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

^b HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

Author keywords

DNA methyltransferase 3a; Hepatocellular carcinoma; microRNA 450a

Indexed keywords

DNA METHYLTRANSFERASE 3A; MESSENGER RNA; MICRORNA;

ARTICLE; CANCER GENETICS; CELL PROLIFERATION; CELL STRAIN HEPG2; CONTROLLED STUDY; ENZYME ANALYSIS; HUMAN; HUMAN CELL; HUMAN TISSUE; LIVER CARCINOGENESIS; LIVER CELL CARCINOMA;

EID: 79960221302     PISSN: 17920981     EISSN: 17921015     Source Type: Journal    
DOI: 10.3892/etm.2011.288     Document Type: Article

References (28)

1. Calin GA and Croce CM: MicroRNA signatures in human cancers. Nat Rev Cancer 6: 857-866, 2006.
2. Gregory RI and Shiekhattar R: MicroRNA biogenesis and cancer. Cancer Res 65: 3509-3512, 2005.
3. Lu J, Getz G, Miska EA, et al: MicroRNA expression profiles classify human cancers. Nature 435: 834-838, 2005.
4. Meng F, Henson R, Wehbe-Janek H, Ghoshal K, Jacob ST and Patel T: MicroRNA-21 regulates expression of the PTEN tumor suppressor gene in human hepatocellular cancer. Gastroenterology 133: 647-658, 2007.
5. Gramantieri L, Ferracin M, Fornari F, et al: Cyclin G1 is a target of miR-122a, a microRNA frequently downregulated in human hepatocellular carcinoma. Cancer Res 67: 6092-6099, 2007.
6. Murakami Y, Yasuda T, Saigo K, et al: Comprehensive analysis of microRNA expression patterns in hepatocellular carcinoma and non-tumorous tissues. Oncogene 25: 2537-2745, 2006.
7. Budhu A, Jia HL, Forgues M, et al: Identification of metastasis-related microRNAs in hepatocellular carcinoma. Hepatology 47: 897-907, 2008.
8. Shah YM, Morimura K, Yang Q, Tanabe T, Takagi M and Gonzalez FJ: Peroxisome proliferator-activated receptor alpha regulates a microRNA-mediated signaling cascade responsible for hepatocellular proliferation. Mol Cell Biol 27: 4238-4247, 2007.
9. Huang YS, Dai Y, Yu XF, et al: Microarray analysis of microRNA expression in hepatocellular carcinoma and non-tumorous tissues without viral hepatitis. J Gastroenterol Hepatol 23: 87-94, 2008.
10. Jiang J, Gusev Y, Aderca I, et al: Association of microRNA expression in hepatocellular carcinomas with hepatitis, cirrhosis, and patient survival. Clin Cancer Res 14: 419-427, 2008.
11. Varnholt H, Drebber U, Schulze F, et al: MicroRNA gene expression profile of hepatitis C virus-associated hepatocellular carcinoma. Hepatology 47: 1223-1232, 2008.
12. Ladeiro Y, Couchy G, Balabaud C, et al: MicroRNA profiling in hepatocellular tumors is associated with clinical features and oncogene/tumor-suppressor gene mutations. Hepatology 47: 1955-1963, 2008.
13. Yang L, Ma Z, Wang D, Zhao W, Chen L and Wang G: MicroRNA-602 regulating tumor suppressive gene RASSF1A is overexpressed in hepatitis B virus-infected liver and hepatocellular carcinoma. Cancer Biol Ther 9: 1-6, 2010.
14. Li HP, Leu YW and Chang YS: Epigenetic changes in virus-associated human cancers. Cell Res 15: 262-271, 2005.
15. Park IY, Sohn BH, Yu E, et al: Aberrant epigenetic modifications in hepatocarcinogenesis induced by hepatitis B virus X protein. Gastroenterology 132: 1476-1494, 2007.
16. Tong A, Gou L, Lau QC, et al: Proteomic profiling identifies aberrant epigenetic modifications induced by hepatitis B virus X protein. J Proteome Res 8: 1037-1046, 2009.
17. Saito Y, Liang G, Egger G, et al: Specific activation of microRNA-127 with downregulation of the proto-oncogene BCL6 by chromatin-modifying drugs in human cancer cells. Cancer Cell 9: 435-443, 2006.
18. Fabbri M, Garzon R, Cimmino A, et al: MicroRNA-29 family reverts aberrant methylation in lung cancer by targeting DNA methyltransferases 3A and 3B. Proc Natl Acad Sci USA 104: 15805-15810, 2007.
19. Garzon R, Fabbri M, Cimmino A, Calin GA and Croce C: MicroRNA expression and function in cancer. Trends Mol Med 12: 580-587, 2006.
20. Kutay H, Bai S, Datta J, et al: Downregulation of miR-122 in the rodent and human hepatocellular carcinomas. J Cell Biochem 99: 671-678, 2006.
21. Jacob JR, Sterczer A, Toshkov IA, et al: Integration of woodchuck hepatitis and N-myc rearrangement determine size and histologic grade of hepatic tumors. Hepatology 39: 1008-1016, 2004.
22. Harada H, Nagai H, Ezura Y, et al: Down-regulation of a novel gene, DRLM, in human liver malignancy from 4q22 that encodes a NAP-like protein. Gene 296: 171-177, 2002.
23. Wong QW, Lung RW, Law PT, et al: MicroRNA-223 is commonly repressed in hepatocellular carcinoma and potentiates expression of Stathmin1. Gastroenterology 135: 257-269, 2008.
24. Oh BK, Kim H, Park HJ, et al: DNA methyltransferase expression and DNA methylation in human hepatocellular carcinoma and their clinicopathological correlation. Int J Mol Med 20: 65-73, 2007.
25. Eads CA, Danenberg KD, Kawakami K, Saltz LB, Danenberg PV and Laird PW: CpG island hypermethylation in human colorectal tumors is not associated with DNA methyltransferase overexpression. Cancer Res 59: 2302-2306, 1999.
26. Ding WJ, Fang JY, Chen XY and Peng YS: The expression and clinical significance of DNA methyltransferase proteins in human gastric cancer. Dig Dis Sci 53: 2083-2089, 2008.
27. Fang JY, Cheng ZH, Chen YX, et al: Expression of DNMT1, demethylase, MeCP2 and methylation of tumor-related genes in human gastric cancer. World J Gastroenterol 10: 3394-3398, 2004.
28. Wang YA, Kamarova Y, Shen KC, et al: DNA methyltransferase-3a interacts with p53 and represses p53-mediated gene expression. Cancer Biol Ther 4: 1138-1143, 2005.