Evaluation of mechanical and rheological properties of metronidazole gel as local delivery system

Archives of Pharmacal Research

Volumn 34, Issue 6, 2011, Pages 931-940

  Jelvehgari, Mitra ^a   Montazam, Hassan ^b  

^a TABRIZ UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^b ISLAMIC AZAD UNIVERSITY   (Iran)

Author keywords

Anionic emulsifying wax; Metronidazole; Release; Rheological properties

Indexed keywords

EMULSIFYING AGENT; GLYCEROL; LACTIC ACID; METRONIDAZOLE;

ADHESION; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; COMPRESSION; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DRUG DELIVERY SYSTEM; DRUG FORMULATION; DRUG RELEASE; GEL; MUCOSA; NONHUMAN; PH; RAT; SKIN TEST; VISCOSITY;

ADHESIVENESS; ADMINISTRATION, CUTANEOUS; ANIMALS; ANTI-INFECTIVE AGENTS; EXCIPIENTS; GELS; HARDNESS; HYDROGEN-ION CONCENTRATION; METRONIDAZOLE; MODELS, BIOLOGICAL; MUCOUS MEMBRANE; RABBITS; RATS; RHEOLOGY; ROSACEA; SKIN IRRITANCY TESTS; SORBITOL; VISCOSITY;

EID: 79960213325     PISSN: 02536269     EISSN: 19763786     Source Type: Journal    
DOI: 10.1007/s12272-011-0610-5     Document Type: Article

References (25)

1. A. Ahuja R. K. Khar J. Ali 1997 Mucoadhesive drug delivery systems Drug Dev. Ind. Pharm. 23 489 515 10.3109/03639049709148498 1:CAS:528: DyaK2sXivFWku7g%3D (Pubitemid 27241128)
2. Bhalla, V. H. and Deshpande, S. G., In Proceedings of International Symposium on innovation in Pharmaceutical Sciences and Technology, Sri, B. V. (Ed.). Patel Education Trust, pp. 74, (1990).
3. H. K. Choi J. H. Jung J. M. Ryu S. J. Yoon Y. K. Oh I. S. Kim 1998 Trails of in-situ gelling and mucoadhesive acetaminophen liquid suppository Int. J. Pharm. 165 33 44 10.1016/S0378-5173(97)00386-4 1:CAS:528:DyaK1cXis1Wru7w%3D (Pubitemid 28218342)
4. P. Colombo P. L. Catellani N. A. Peppas L. Maggi U. Conte 1992 Swelling characteristics of hydrophilic matrices for controlled release. New dimensionless number to describe the swelling and release behavior Int. J. Pharm. 88 99 109 10.1016/0378-5173(92)90307-N 1:CAS:528:DyaK3sXms1OgsQ%3D%3D (Pubitemid 23000412)
5. th ed. John Wiely & Sons Inc., pp. 295-296, (1995).
6. M. L. DeMartine E. L. Cussler 1975 Predicting subjective spreadability, viscosity, and stickiness J. Pharm. Sci. 64 976 982 1133755 10.1002/jps. 2600640618 1:CAS:528:DyaE2MXkvVCkurc%3D
7. I. C. De Paula G. G. Ortega V. L. Bassani P. R. Petrovick 1998 Development of ointment formulations prepared with achyrocline satureioides spray-dried extracts Drug Dev. Ind. Pharm. 24 235 241 9876580 10.3109/03639049809085615 (Pubitemid 28119241)
8. J. Y. Fang T. L. Hwang Y. L. Leu 2003 Effect of enhancers and retarders on percutaneous absorption of flurbiprofen from hydrogels Int. J. Pharm. 250 313 325 12527159 10.1016/S0378-5173(02)00540-9 1:CAS:528:DC%2BD3sXis1WnsQ%3D%3D (Pubitemid 36084356)
9. I. A. Hadi H. E. Ugriné A. M. Farouk M. Shayoub 1989 Formulation of polyethylene glycol ointment bases suitable for tropical and subtropical climates. I Acta Pharm. Hung. 59 137 142 2763848 1:CAS:528:DyaL1MXlsVSgu78%3D (Pubitemid 20287719)
10. Hunt, G., Kearney, P., and Kellaway I. W., Mucoadhesive polymers in drug delivery systems, In Johnson, P., Lloyd Jones, J. G., and Ellis, H. (Eds.). Drug delivery systems. Fundamentals and Techniques. England, pp. 180-199, (1987).
11. D. S. Jones A. D. Woolfson A. F. Brown 1997 Textural analysis and flow rheometry of novel, bioadhesive antimicrobial oral gels Pharm. Res. 14 450 457 9144730 10.1023/A:1012091231023 1:CAS:528:DyaK2sXjtVWrsLc%3D (Pubitemid 27205003)
12. T. Keller H. W. Zulliger R. Niederer 1982 Simple model for measuring spreadability of suppository bases Acta Pharm. Technol. 28 277 286 1:CAS:528:DyaL3sXhtFels7c%3D (Pubitemid 13153627)
13. R. W. Korsmeyer R. Gurny E. Doelker P. Buri N. A. Peppas 1983 Mechanism of solute release from porous hydrophilic polymer Int. J. Pharm. 15 25 35 10.1016/0378-5173(83)90064-9 1:CAS:528:DyaL3sXksVens7Y%3D (Pubitemid 13092121)
14. A. G. Mikos N. A. Peppas 1990 Bioadhesive analysis of controlled-release systems. IV. An experimental method for testing the adhesion of microparticles with mucus J. Control. Release 12 31 37 10.1016/0168-3659(90)90180-2 1:CAS:528:DyaK3cXisVSnsr0%3D (Pubitemid 20101609)
15. Y. Miyachi S. Imamura Y. Niwa 1986 Anti-oxidant action of metronidazole: a possible mechanism of action in rosacea Br. J. Dermatol. 114 231 234 2936372 10.1111/j.1365-2133.1986.tb02802.x 1:CAS:528:DyaL28Xht1aku7k%3D (Pubitemid 16131430)
16. M. Nyman-Pantelidis A. Nilsson Z. G. Wagner O. Borgå 1994 Pharmacokinetics and retrograde colonic spread of budesonide enemas in patients with distal ulcerative colitis Aliment. Pharmacol. Ther. 8 617 622 7696451 10.1111/j.1365-2036.1994.tb00339.x 1:STN:280:DyaK2M3htVClsQ%3D%3D (Pubitemid 24381362)
17. L. Panigrahi T. John A. Shariff S. Rani R. Hiremath 1997 Formulation and evaluation of lincomycin HCL gels Ind. J. Pharm. Sci. 59 330 332 1:CAS:528:DyaK1cXhtFSrtrw%3D (Pubitemid 28055405)
18. K. Park J. R. Robinson 1984 Bioadhesive polymers as platforms for oral-controlled drug delivery: method to study bioadhesion Int. J. Pharm. 19 107 127 10.1016/0378-5173(84)90154-6 1:CAS:528:DyaL2cXkslykt70%3D (Pubitemid 14144031)
19. R. W. Rance 1973 Studies of the factors controlling the action of hair sprays. I: The spreading of hair spray resin solutions on hair J. Soc. Cosmet. Chem. 24 501 522
20. Raymond, C. R., Paul, J. Sh., Paul, J. W., Ray, R., Paul, Sh., and Paul, W., Hand book of pharmaceutical excipient, 4th Ed. Pharmaceutical press, London, pp. 35-37, (2004).
21. P. L. Ritger N. A. Peppas 1987 A simple equation for description of solute release I. Fickian and non-fickian release from non-swellable devices in the form of slabs, spheres, cylinders, or discs J. Control. Release 5 23 36 10.1016/0168-3659(87)90034-4 1:CAS:528:DyaL2sXkvVeku7o%3D (Pubitemid 17106643)
22. Sande, M. A. and Mandell, G. L., Chemotherapy of microbial diseases. In Goodman, Gillman (ed). The pharmacological basis of therapeutics, 8th Ed. Maxwell Macmillan, New York, pp. 1018-1200, (1991).
23. L. M. Sanders J. S. Kent G. I. McRae B. H. Vickery T. R. Tice D. H. Lewis 1999 Controlled release of luteinizing hormone releasing analogue from poly (D, L-Lactide-coglycolide) microspheres Int. Pharm. Sci. 1 S385
24. B. Vennat D. Gross M. P. Pouget A. Pourrat H. Pourrat 1995 Comparison of the physical stability of astringent hydrogels based on cellulose derivatives Drug Dev. Ind. Pharm. 21 559 570 10.3109/03639049509048123 1:CAS:528: DyaK2MXjvVans7s%3D
25. J. H. Waite 1990 Marine adhesive proteins: natural composite thermosets Int. J. Biol. Macromol. 12 139 144 2127695 10.1016/0141-8130(90)90065-I 1:CAS:528:DyaK3cXktF2msb0%3D (Pubitemid 20273964)