Mitogen-activated protein kinases p38 and JNK mediate Actinobacillus pleuropneumoniae exotoxin ApxI-induced apoptosis in porcine alveolar macrophages

Veterinary Microbiology

Volumn 151, Issue 3-4, 2011, Pages 372-378

  Wu, Chi Ming ^a   Chen, Zeng Weng ^a   Chen, Ter Hsin ^a   Liao, Jiunn Wang ^a   Lin, Cheng Chung ^a   Chien, Maw Sheng ^a   Lee, Wei Cheng ^a   Hsuan, Shih Ling ^a  

^a NATIONAL CHUNG HSING UNIVERSITY   (Taiwan)

Author keywords

Actinobacillus pleuropneumoniae; Apoptosis; ApxI; Caspase; Mitogen activated protein kinase; Porcine alveolar macrophage

Indexed keywords

APXI EXOTOXIN; BACTERIAL TOXIN; CASPASE 3; CASPASE 8; CASPASE 9; MITOGEN ACTIVATED PROTEIN KINASE P38; PROTEIN BID; STRESS ACTIVATED PROTEIN KINASE; UNCLASSIFIED DRUG;

ACTINOBACILLUS PLEUROPNEUMONIAE; ANIMAL CELL; APOPTOSIS; ARTICLE; CELL PROTECTION; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; LUNG ALVEOLUS MACROPHAGE; NONHUMAN; PROTEIN FUNCTION; PROTEIN SYNTHESIS INHIBITION; SIGNAL TRANSDUCTION; SWINE;

ACTINOBACILLUS PLEUROPNEUMONIAE; ANIMALS; APOPTOSIS; BACTERIAL PROTEINS; BH3 INTERACTING DOMAIN DEATH AGONIST PROTEIN; CASPASE 3; CASPASE 8; CASPASE 9; CELLS, CULTURED; ENZYME ACTIVATION; EXOTOXINS; HEMOLYSIN PROTEINS; JNK MITOGEN-ACTIVATED PROTEIN KINASES; MACROPHAGES, ALVEOLAR; MAP KINASE SIGNALING SYSTEM; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHORYLATION; SWINE;

ACTINOBACILLUS PLEUROPNEUMONIAE; MYCOPLASMA; SUIDAE; SUS;

EID: 79960189295     PISSN: 03781135     EISSN: 18732542     Source Type: Journal    
DOI: 10.1016/j.vetmic.2011.03.033     Document Type: Article

References (26)

1. Basu S., Pathak S.K., Banerjee A., Pathak S., Bhattacharyya A., Yang Z., Talarico S., Kundu M., Basu J. Execution of macrophage apoptosis by PE_PGRS33 of Mycobacterium tuberculosis is mediated by Toll-like receptor 2-dependent release of tumor necrosis factor-alpha. J. Biol. Chem. 2007, 282:1039-1050.
2. Bosshart H., Heinzelmann M. Targeting bacterial endotoxin: two sides of a coin. Ann. N. Y. Acad. Sci. 2007, 1096:1-17.
3. Chien M.S., Chan Y.Y., Chen Z.W., Wu C.M., Liao J.W., Chen T.H., Lee W.C., Yeh K.S., Hsuan S.L. Actinobacillus pleuropneumoniae serotype 10 derived ApxI induces apoptosis in porcine alveolar macrophages. Vet. Microbiol. 2009, 135:327-333.
4. Choi W.S., Eom D.S., Han B.S., Kim W.K., Han B.H., Choi E.J., Oh T.H., Markelonis G.J., Cho J.W., Oh Y.J. Phosphorylation of p38 MAPK induced by oxidative stress is linked to activation of both caspase-8- and -9-mediated apoptotic pathways in dopaminergic neurons. J. Biol. Chem. 2004, 279:20451-20460.
5. Clerk A., Kemp T.J., Harrison J.G., Mullen A.J., Barton P.J., Sugden P.H. Up-regulation of c-jun mRNA in cardiac myocytes requires the extracellular signal-regulated kinase cascade, but c-Jun N-terminal kinases are required for efficient up-regulation of c-Jun protein. Biochem. J. 2002, 368:101-110.
6. Cuenda A., Rouse J., Doza Y.N., Meier R., Cohen P., Gallagher T.F., Young P.R., Lee J.C. SB 203580 is a specific inhibitor of a MAP kinase homologue which is stimulated by cellular stresses and interleukin-1. FEBS Lett. 1995, 364:229-233.
7. Danial N.N., Korsmeyer S.J. Cell death: critical control points. Cell 2004, 116:205-219.
8. Davis R.J. Signaling transduction by the JNK group of MAP kinase. Cell 2000, 103:239-252.
9. Dérijard B., Hibi M., Wu I.H., Barrett T., Su B., Deng T., Karin M., Davis R.J. JNK1: a protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain. Cell 1994, 76:1025-1037.
10. Frey J., Kuhnert P. RTX toxins in Pasteurellaceae. Int. J. Med. Microbiol. 2002, 292:149-158.
11. Galindo C.L., Fadl A.A., Sha J., Gutierrez C., Popov V.L., Boldogh I., Aggarwal B.B., Chopra A.K. Aeromonas hydrophila cytotoxic enterotoxin activates mitogen-activated protein kinases and induces apoptosis in murine macrophages and human intestinal epithelial cells. J. Biol. Chem. 2004, 279:37597-37612.
12. Gottschalk M., Taylor D.J. Actinobacillus pleuropneumoniae. Diseases of Swine 2006, 563-576. Blackwell Publishing, Ames, IA. 9th edn. B.E. Straw, J.J. Zimmerman, S. D'Allaire, D.J. Taylor (Eds.).
13. Johnson G.L., Lapadat R. Mitogen-activated protein kinase pathways mediated by ERK, JNK, and p38 protein kinases. Science 2002, 298:1911-1912.
14. Kamp E.M., Popma J.K., Anakotta J., Smits M.A. Identification of hemolytic and cytotoxic proteins of Actinobacillus pleuropneumoniae by use of monoclonal antibodies. Infect. Immun. 1991, 59:3079-3085.
15. Kim B.M., Chung H.W. Desferrioxamine (DFX) induces apoptosis through the p38-caspase8-Bid-Bax pathway in PHA-stimulated human lymphocytes. Toxicol. Appl. Pharmacol. 2008, 228:24-31.
16. Lee B.C., Choi S.H., Kim T.S. Vibrio vulnificus RTX toxin plays an important role in the apoptotic death of human intestinal epithelial cells exposed to Vibrio vulnificus. Microbes Infect. 2008, 10:1504-1513.
17. N'Guessan P.D., Schmeck B., Ayim A., Hocke A.C., Brell B., Hammerschmidt S., Rosseau S., Suttorp N., Hippenstiel S. Streptococcus pneumoniae R6x induced p38 MAPK and JNK-mediated caspase-dependent apoptosis in human endothelial cells. Thromb. Haemost. 2005, 94:295-303.
18. Okinaga T., Kasai H., Tsujisawa T., Nishihara T. Role of caspases in cleavage of lamin A/C and PARP during apoptosis in macrophages infected with a periodontopathic bacterium. J. Med. Microbiol. 2007, 56:404-1399.
19. Pagès G., Lenormand P., L'Allemain G., Chambard J.C., Meloche S., Pouysségur J. Mitogen-activated protein kinases p42mapk and p44mapk are required for fibroblast proliferation. Proc. Natl. Acad. Sci. U.S.A. 1993, 90:8319-8323.
20. Reddy K.B., Nabha S.M., Atanaskova N. Role of MAP kinase in tumor progression and invasion. Cancer Metastasis Rev. 2003, 22:395-403.
21. Seah J.N., Kwang J. Localization of linear cytotoxic and pro-apoptotic epitopes in RTX toxin ApxIII of Actinobacillus pleuropneumoniae. Vaccine 2004, 22:1494-1497.
22. Song J.J., Lee Y.J. Daxx deletion mutant (amino acids 501-625)-induced apoptosis occurs through the JNK/p38-Bax-dependent mitochondrial pathway. J. Cell Biochem. 2004, 92:1257-1270.
23. Thumbikat P., Dileepan T., Kannan M.S., Maheswaran S.K. Mechanisms underlying Mannheimia haemolytica leukotoxin-induced oncosis and apoptosis of bovine alveolar macrophages. Microb. Pathog. 2005, 38:161-172.
24. Tournier C., Hess P., Yang D.D., Xu J., Turner T.K., Nimnual A., Bar-Sagi D., Jones S.N., Flavell R.A., Davis R.J. Requirement of JNK for stress-induced activation of the cytochrome c-mediated death pathway. Science 2000, 288:870-874.
25. Wang Z.B., Liu Y.Q., Cui Y.F. Pathways to caspase activation. Cell Biol. Int. 2005, 29:489-496.
26. Weinstein S.L., Sanghera J.S., Lemke K., DeFranco A.L., Pelech S.L. Bacterial lipopolysaccharide induces tyrosine phosphorylation and activation of mitogen-activated protein kinase in macrophage. J. Biol. Chem. 1992, 267:14955-14962.