Individualized dosing regimens in children based on population PKPD modelling: Are we ready for it?

International Journal of Pharmaceutics

Volumn 415, Issue 1-2, 2011, Pages 9-14

  Knibbe, Catherijne A J ^a,b   Danhof, Meindert ^b  

^a ST ANTONIUS HOSPITAL   (Netherlands)

^b LEIDEN UNIVERSITY   (Netherlands)

Author keywords

Children; Dosing guidelines; Paediatrics; Pharmacodynamics; Pharmacokinetics; PKPD modelling

Indexed keywords

AMINOGLYCOSIDE; ISOFLURANE; MORPHINE; ZIDOVUDINE;

ALGORITHM; ARTICLE; BLOOD SAMPLING; BODY WEIGHT; CLINICAL RESEARCH; DOSE RESPONSE; DRUG ABSORPTION; DRUG DISPOSITION; DRUG DISTRIBUTION; DRUG DOSE REGIMEN; DRUG EFFICACY; DRUG EXCRETION; DRUG FORMULATION; DRUG METABOLISM; DRUG STRUCTURE; GLUCURONIDATION; HUMAN; METHODOLOGY; MINIMUM LUNG ALVEOLUS CONCENTRATION; PEDIATRICS; PHARMACOKINETIC PHARMACODYNAMIC MODEL; PLASMA CONCENTRATION-TIME CURVE; POPULATION MODEL; PREDICTIVE VALUE; PRIORITY JOURNAL; SIMULATION;

BIOMARKERS, PHARMACOLOGICAL; CHILD; HUMANS; INDIVIDUALIZED MEDICINE; MODELS, BIOLOGICAL; PHARMACOKINETICS; PHARMACOLOGICAL PROCESSES;

EID: 79960185229     PISSN: 03785173     EISSN: 18733476     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2011.02.056     Document Type: Article

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