Cholinergic modulation of dendritic cell function

Journal of Neuroimmunology

Volumn 236, Issue 1-2, 2011, Pages 47-56

  Salamone, Gabriela ^a,b   Lombardi, Gabriela ^c   Gori, Soledad ^a   Nahmod, Karen ^a   Jancic, Carolina ^a   Amaral, María Marta ^a   Vermeulen, Mónica ^a,b   Español, Alejandro ^c   Sales, María Elena ^c   Geffner, Jorge ^a,b  

^a INST DE INVEST HEMATOLOGICAS   (Argentina)

^b UNIVERSIDAD DE BUENOS AIRES   (Argentina)

^c Centre de Estudios Farmacologicos y Botanicos   (Argentina)

Author keywords

Acetylcholine; Cholinergic system; Dendritic cells; Muscarinic receptors

Indexed keywords

ACETYLCHOLINE; ACETYLCHOLINESTERASE; ATROPINE; CARBACHOL; CD86 ANTIGEN; CHOLINE ACETYLTRANSFERASE; ETANERCEPT; HLA DR ANTIGEN; INTERLEUKIN 10; INTERLEUKIN 12; INTERLEUKIN 8; LIPOPOLYSACCHARIDE; MUSCARINIC M3 RECEPTOR; MUSCARINIC M4 RECEPTOR; MUSCARINIC M5 RECEPTOR; NEOSTIGMINE; TUMOR NECROSIS FACTOR ALPHA;

ANTIGEN EXPRESSION; ARTICLE; CELL DIFFERENTIATION; CELL FUNCTION; CELL MATURATION; CHOLINERGIC SYSTEM; CONTROLLED STUDY; CYTOKINE PRODUCTION; DENDRITIC CELL; ENZYME ACTIVITY; HUMAN; HUMAN CELL; IMMUNOMODULATION; MALE; PRIORITY JOURNAL; PROTEIN EXPRESSION; T LYMPHOCYTE;

ACETYLCHOLINE; ACETYLCHOLINESTERASE; CELL DIFFERENTIATION; CELLS, CULTURED; CHOLINE O-ACETYLTRANSFERASE; CHOLINERGIC AGONISTS; CHOLINERGIC ANTAGONISTS; DENDRITIC CELLS; HUMANS; MALE; RECEPTORS, MUSCARINIC;

EID: 79960183053     PISSN: 01655728     EISSN: 18728421     Source Type: Journal    
DOI: 10.1016/j.jneuroim.2011.05.007     Document Type: Article

References (25)

1. Aicher A., Heeschen C., Mohaupt M., Cooke J.P., Zeiher A.M., Dimmeler S. Nicotine strongly activates dendritic cell-mediated adaptive immunity: potential role for progression of atherosclerotic lesions. Circulation 2003, 107:604-611.
2. Ardavin C., Amigorena S., Reis e Sousa C. Dendritic cells: immunobiology and cancer immunotherapy. Immunity 2004, 20:17-23.
3. Bernik T.R., Friedman S.G., Ochani M., DiRaimo R., Susarla S., Czura C.J., Tracey K.J. Cholinergic antiinflammatory pathway inhibition of tumor necrosis factor during ischemia reperfusion. J. Vasc. Surg. 2002, 36:1231-1236.
4. Blalock J.E., Weigent D.A. Pituitary control of immune cells. Immunol Today 1994, 15:39.
5. Borovikova L.V., Ivanova S., Nardi D., Zhang M., Yang H., Ombrellino M., Tracey K.J. Role of vagus nerve signaling in CNI-1493-mediated suppression of acute inflammation. Auton. Neurosci. 2000, 85:141-147.
6. Borovikova L.V., Ivanova S., Zhang M., Yang H., Botchkina G.I., Watkins L.R., Wang H., Abumrad N., Eaton J.W., Tracey K.J. Vagus nerve stimulation attenuates the systemic inflammatory response to endotoxin. Nature 2000, 405:458-462.
7. Fujii T., Tajima S., Yamada S., Watanabe Y., Sato K.Z., Matsui M., Misawa H., Kasahara T., Kawashima K. Constitutive expression of mRNA for the same choline acetyltransferase as that in the nervous system, an acetylcholine-synthesizing enzyme, in human leukemic T-cell lines. Neurosci. Lett. 1999, 259:71-74.
8. Galvis G., Lips K.S., Kummer W. Expression of nicotinic acetylcholine receptors on murine alveolar macrophages. J. Mol. Neurosci. 2006, 30:107-108.
9. Gao F.G., Wan da F., Gu J.R. Ex vivo nicotine stimulation augments the efficacy of therapeutic bone marrow-derived dendritic cell vaccination. Clin Cancer Res 2007, 13:3706-3712.
10. Ghia J.E., Blennerhassett P., Kumar-Ondiveeran H., Verdu E.F., Collins S.M. The vagus nerve: a tonic inhibitory influence associated with inflammatory bowel disease in a murine model. Gastroenterology 2006, 131:1122-1130.
11. Guermonprez P., Valladeau J., Zitvogel L., Thery C., Amigorena S. Antigen presentation and T cell stimulation by dendritic cells. Annu. Rev. Immunol. 2002, 20:621-667.
12. Kawashima K., Fujii T. Extraneuronal cholinergic system in lymphocytes. Pharmacol. Ther. 2000, 86:29-48.
13. Kawashima K., Fujii T., Watanabe Y., Misawa H. Acetylcholine synthesis and muscarinic receptor subtype mRNA expression in T-lymphocytes. Life Sci 1998, 62(17-18):1701-1705.
14. Kurzen H., Wessler I., Kirkpatrick C.J., Kawashima K., Grando S.A. The non-neuronal cholinergic system of human skin. Horm. Metab. Res. 2007, 39:125-135.
15. Liu T., Xie C., Chen X., Zhao F., Liu A.M., Cho D.B., Chong J., Yang P.C. Role of muscarinic receptor activation in regulating immune cell activity in nasal mucosa. Allergy 2010, 65:969-977.
16. Nouri-Shirazi M., Guinet E. Evidence for the immunosuppressive role of nicotine on human dendritic cell functions. Immunology 2003, 109:365-373.
17. Pavlov V.A., Tracey K.J. The cholinergic anti-inflammatory pathway. Brain Behav Immun 2005, 19:493-499.
18. Reis e Sousa C. Dendritic cells in a mature age. Nat. Rev. Immunol. 2006, 6:476-483.
19. Sabatte J., Maggini J., Nahmod K., Amaral M.M., Martinez D., Salamone G., Ceballos A., Giordano M., Vermeulen M., Geffner J. Interplay of pathogens, cytokines and other stress signals in the regulation of dendritic cell function. Cytokine Growth Factor Rev 2007, 18:5-17.
20. Song P., Sekhon H.S., Jia Y., Keller J.A., Blusztajn J.K., Mark G.P., Spindel E.R. Acetylcholine is synthesized by and acts as an autocrine growth factor for small cell lung carcinoma. Cancer Res 2003, 63:214-221.
21. Steinman R.M. Some interfaces of dendritic cell biology. APMIS 2003, 111:675-697.
22. Tracey K.J. Reflex control of immunity. Nat. Rev. Immunol. 2009, 9:418-428.
23. van der Zanden E.P., Snoek S.A., Heinsbroek S.E., Stanisor O.I., Verseijden C., Boeckxstaens G.E., Peppelenbosch M.P., Greaves D.R., Gordon S., De Jonge W.J. Vagus nerve activity augments intestinal macrophage phagocytosis via nicotinic acetylcholine receptor alpha4beta2. Gastroenterology 2009, 137:1029-1039. 1039 e1021-1024.
24. van Westerloo D.J., Giebelen I.A., Florquin S., Bruno M.J., Larosa G.J., Ulloa L., Tracey K.J., van der Poll T. The vagus nerve and nicotinic receptors modulate experimental pancreatitis severity in mice. Gastroenterology 2006, 130:1822-1830.
25. Zimring J.C., Kapp L.M., Yamada M., Wess J., Kapp J.A. Regulation of CD8+ cytolytic T lymphocyte differentiation by a cholinergic pathway. J. Neuroimmunol. 2005, 164:66-75.