Melatonin: Can it stop the ringing?

Annals of Otology, Rhinology and Laryngology

Volumn 120, Issue 7, 2011, Pages 433-440

  Hurtuk, Agnes ^a   Dome, Claudia ^a   Holloman, Christopher H ^b   Wolfe, Kelly ^a   Welling, D Bradley ^a   Dodson, Edward E ^a   Jacob, Abraham ^a  

^a THE OHIO STATE UNIVERSITY WEXNER MEDICAL CENTER   (United States)

^b OHIO STATE UNIVERSITY   (United States)

Author keywords

Melatonin; Tinnitus

Indexed keywords

MELATONIN; PLACEBO;

ABSENCE OF SIDE EFFECTS; ADULT; AGED; ANXIETY; ARTICLE; AUDIOMETRY; BECK DEPRESSION INVENTORY; CHRONIC DISEASE; CONTROLLED STUDY; CROSSOVER PROCEDURE; DEPRESSION; DISEASE DURATION; DOUBLE BLIND PROCEDURE; DRUG EFFICACY; FEMALE; FOLLOW UP; HUMAN; MAJOR CLINICAL STUDY; MALE; NAMED INVENTORIES, QUESTIONNAIRES AND RATING SCALES; NOISE; OUTCOME ASSESSMENT; PITTSBURGH SLEEP QUALITY INDEX; PRIORITY JOURNAL; PROSPECTIVE STUDY; RANDOMIZED CONTROLLED TRIAL; SCORING SYSTEM; SELF RATED TINNITUS; SEX DIFFERENCE; SLEEP; TINNITUS; TINNITUS SEVERITY INDEX; TREATMENT RESPONSE;

EID: 79960177515     PISSN: 00034894     EISSN: None     Source Type: Journal    
DOI: 10.1177/000348941112000703     Document Type: Article

References (29)

1. Folmer RL. Long-term reductions in tinnitus severity. BMC Ear Nose Throat Disord 2002;2:3-11.
2. Bauer CA, Brozoski TJ. Effect of gabapentin on the sensation and impact of tinnitus. Laryngoscope 2006;116:675-81. (Pubitemid 44318020)
3. Dineen R, Doyle J, Bench J. Managing tinnitus: a comparison of different approaches to tinnitus management training. Br J Audiol 1997;31:331-44. (Pubitemid 27480574)
4. Attenburrow ME, Cowen PJ, Sharpley AL. Low dose melatonin improves sleep in healthy middle-aged subjects. Psychopharmacology 1996;126:179-81. (Pubitemid 26246769)
5. Pires MLN, Benedito-Silva AA, Pinto L, Souza L, Vismari L, Calil HM. Acute effects of low doses of melatonin on the sleep of young healthy subjects. J Pineal Res 2001;31:326-32. (Pubitemid 33032948)
6. Rosenberg SI, Silverstein H, Rowan PT, Olds MJ. Effect of melatonin on tinnitus. Laryngoscope 1998;108:305-10. (Pubitemid 28136634)
7. Megwalu UC, Finnell JE, Piccirillo JF. The effects of melatonin on tinnitus and sleep. Otolaryngol Head Neck Surg 2006;134:210-3. (Pubitemid 43187118)
8. Lopez-Gonzalez MA, Santiago AM, Esteban-Ortega F. Sulpiride and melatonin decrease tinnitus perception modulating the auditolimbic dopaminergic pathway. J Otolaryngol 2007;36:213-9. (Pubitemid 47518412)
9. Neri G, De Stefano A, Baffa C, et al. Treatment of central and sensorineural tinnitus with orally administered melatonin and sulodexide: personal experience from a randomized controlled study. Acta Otorhinolaryngol Ital 2009;29:86-91.
10. Penner MJ, Klafter EJ. Measure of tinnitus: step size, matches to imagined tones, and masking patterns. Ear Hear 1992;13:410-6. (Pubitemid 23019459)
11. Mitchell CR, Vernon JA, Creedon TA. Measuring tinnitus parameters: loudness, pitch, and maskability. J Am Acad Audiol 1993;4:139-51.
12. Henry JA, Fausti SA, Flick CL, Helt WJ, Ellingson RM. Computer-automated clinical technique for tinnitus quantification. Am J Audiol 2000;9:36-49.
13. Meikle MB. Methods for evaluation of tinnitus relief procedures. In: Aran JM, Dauman R, eds. Tinnitus 91: proceedings of the Fourth International Tinnitus Seminar. Amsterdam, the Netherlands: Kugler, 1992:555-62.
14. Buysse DJ, Reynolds CF III, Monk TH, Berman SR, Kupfer DJ. The Pittsburgh Sleep Quality Index: a new instrument for psychiatric practice and research. Psychiatry Res 1989;28:193-213. (Pubitemid 19144991)
15. Beck AT, Ward CH, Mendelson M, Mock J, Erbaugh J. An inventory for measuring depression. Arch Gen Psychiatry 1961;4:561-71.
16. Aldhous M, Franey C, Wright J, Arendt J. Plasma concentrations of melatonin in man following oral absorption of different preparations. Br J Clin Pharmacol 1985;19:517-21. (Pubitemid 16254595)
17. Lane EA, Moss HB. Pharmacokinetics of melatonin in man: first pass hepatic metabolism. J Clin Endocrinol Metab 1985;61:1214-6. (Pubitemid 16186729)
18. Waldhauser F, Waldhauser M, Lieberman HR, Deng MH, Lynch HJ, Wurtman RJ. Bioavailability of oral melatonin in humans. Neuroendocrinology 1984;39:307-13. (Pubitemid 14031912)
19. Paulis L, Simko F. Blood pressure modulation and cardiovascular protection by melatonin: potential mechanisms behind. Physiol Res 2007;56:671-84.
20. Asplund R. Sleepiness and sleep in elderly persons with tinnitus. Arch Gerontol Geriatr 2003;37:139-45. (Pubitemid 36918450)
21. Hardeland R. Antioxidative protection by melatonin: multiplicity of mechanisms from radical detoxification to radical avoidance. Endocrine 2005;27:119-30. (Pubitemid 41558444)
22. Kim JB, Jung JY, Ahn JC, Rhee CK, Hwang HJ. Antioxidant and anti-apoptotic effect of melatonin on the vestibular hair cells of rat utricles. Clin Exp Otorhinolaryngol 2009;2:6-12.
23. Bas E, Martinez-Soriano F, Láinez JM, Marco J. An experimental comparative study of dexamethasone, melatonin and tacrolimus in noise-induced hearing loss. Acta Otolaryngol 2009;129:385-9.
24. Simko F, Paulis L. Melatonin as a potential antihypertensive treatment. J Pineal Res 2007;42:319-22. (Pubitemid 46581667)
25. Pirodda A, Raimondi MC, Ferri GG. Exploring the reasons why melatonin can improve tinnitus. Med Hypotheses 2010;75:190-1.
26. Wehr T, Goodwin FK. Tricyclics modulate frequency of mood cycles. Chronobiologia 1979;6:377-85. (Pubitemid 10099455)
27. Leppämäki S, Partonen T, Vakkuri O, Lönnqvist J, Partinen M, Laudon M. Effect of controlled-release melatonin on sleep quality, mood, and quality of life in subjects with seasonal or weather-associated changes in mood and behaviour. Eur Neuropsychopharmacol 2003;13:137-45. (Pubitemid 36506922)
28. Imbesi M, Uz T, Yildiz S, Arslan AD, Manev H. Drugand region-specific effects of protracted antidepressant and cocaine treatment on the content of melatonin MT(1) and MT(2) receptor mRNA in the mouse brain. Int J Neuroprot Neuroregener 2006;2:185-9. (Pubitemid 44744170)
29. Muhr P, Rosenhall U. Self-assessed auditory symptoms, noise exposure, and measured auditory function among healthy young Swedish men. Int J Audiol 2010;49:317-25.