Bacterial reverse mutation test and micronucleus test of fucoxanthin oil from microalgae

Journal of the Food Hygienic Society of Japan

Volumn 52, Issue 3, 2011, Pages 190-193

  Kumiko, Iio ^a   Yumika, Okada ^a   Masaharu, Ishikura ^a  

^a Life Science Institute   (Japan)

Author keywords

Fucoxanthin; Genotoxicity; Microalgae; Micronucleus test; Reverse mutation test

Indexed keywords

FUCOXANTHIN; MUTAGENIC AGENT; OIL; XANTHOPHYLL;

ANIMAL; ARTICLE; CHEMISTRY; GENETICS; INSTITUTE FOR CANCER RESEARCH MOUSE; MALE; MICROALGA; MICRONUCLEUS TEST; MOUSE; MUTAGEN TESTING; SALMONELLA TYPHIMURIUM;

ANIMALS; MALE; MICE; MICE, INBRED ICR; MICROALGAE; MICRONUCLEUS TESTS; MUTAGENICITY TESTS; MUTAGENS; OILS; SALMONELLA TYPHIMURIUM; XANTHOPHYLLS;

BACTERIA (MICROORGANISMS); MUS;

EID: 79960164495     PISSN: 00156426     EISSN: None     Source Type: Journal    
DOI: 10.3358/shokueishi.52.190     Document Type: Article

References (13)

1. Okuzumi, J., Nishino, H., Murakoshi, M., Iwashima, A., Tanaka, Y., Yamane, T., Fujita, Y., Takahashi, T. Inhibitory effects of fucoxanthin, a natural carotenoid, on N-myc expression and cellcycle progression in human malignant tumor cells. Cancer Lett., 55, 75-81 (1990).
2. Okuzumi, J., Takahashi, T., Yamane, T., Kitao, Y., Inagake, M., Ohya, K., Nishino, H., Tanaka, Y. Inhibitory effects of fucoxanthin, a natural carotenoid, on N-ethyl-N-nitro-N-nitrosoguanidine-induced mouse duodenal carcinogenesis. Cancer Lett., 68, 159-168 (1993). (Pubitemid 23090674)
3. Kim, J. M., Araki, S., Kim, D. J., Park, C. B., Takasuka, N., Baba-Toriyama, H., Ota, T., Nir, Z., Khachik, F., Shimidzu, N., Tanaka, Y., Osawa, T., Uraji, T., Murakoshi, M., Nishino, H., Tsuda, H. Chemopreventive effects of carotenoids and curcumins on mouse colon carcinogenesis after 1,2-dimethylhydrazine initiation. Carcinogenesis, 19, 81-85 (1998). (Pubitemid 28376829)
4. Hosokawa, M., Kudo, M., Maeda, H., Kohno, H., Tanaka, T., Miyashita, K. Fucoxanthin inducesapoptosis and enhances the antiproliferative effect of the PPARg ligand, troglitazone, on colon cancer cells. Biochim. Biophys. Acta, 1675, 113-119 (2004). (Pubitemid 39463260)
5. Maeda, H., Hosokawa, M., Sashima, T., Funayama, K., Miyashita, K. Fucoxanthin from edible seaweed, Undaria pinnatifida, shows antiobesity effect through UCP 1 expression in white adipose tissues. Biochem. Biophys. Res. Commun., 332, 392-397 (2005). (Pubitemid 40724991)
6. Maeda, H., Hosokawa, M., Sashima, T., Takahashi, N., Kawada, T., Miyashita, K. Fucoxanthin and its metabolite, fucoxanthinol, suppress adipocyte differentiation in 3T3-L1 cells. Int. J. Mo .Med., 18, 147-152 (2006).
7. Maeda, H., Hosokawa, M., Sashima, T., Funayama, K., Miyashita, K. Effect of medium-chain triacylglycerols on anti-obesity effect of fucoxanthin. J. Oleo. Sci., 56, 615-621 (2007).
8. Kadekaru, T., Toyama, H., Yasumoto, T. Safety evaluation of fucoxanthin purified from Undaria pinnatifida. Nippon Shokuhin Kagaku Kogaku Kaishi, 55, 304-308 (2008).
9. Beppu, F., Niwano, Y., Tsukui, T., Hosokawa, M., Miyashita, K. Single and repeated oral dose toxicity study of fucoxanthin (FX), a marine carotenoid, in mice. J. Toxicol. Sci., 34, 501-510(2009).
10. Beppu, F., Niwano, Y., Sato, E., Kohno, M. Tsukui, T., Hosokawa, M., Miyashita, K. In vitroand in vivo evaluation of mutagenicity of fucoxanthtin (FX) and its metabolite fucoxanthinol (FXOH). J. Toxicol. Sci., 34, 693-698 (2009).
11. Wright, S. W., Jeffrey, S. W. "High-resolution HPLC system for chlorophylls and carotenoidsof marine phytoplankton". Phytoplankton Pigments in Oceanography: Guidelines to Modern Methods. J ffrey, S. W., Mantoura, R. F. C., Wright, S. W., eds. UNESCO Publishing, 1997,. p. 327-341. (ISBN 92-3-103275-5)
12. Maron, D. M., Ames, B. N. Revised methods for the Salmonella mutagenicity test. Mutat. Res., 113, 173-215 (1983). (Pubitemid 13120319)
13. Yahagi, T., Nagao, M., Seino, Y. Matsushima, T., Sugimura, T., Okada, M. Mutagenicities of N-nitrosamines on Salmonella. Mutat. Res., 48, 121-129 (1977).