Brain and serum levels of nerve growth factor in a rat model of Alzheimer's disease

Journal of Alzheimer's Disease

Volumn 25, Issue 2, 2011, Pages 213-217

  Gelfo, Francesca ^a   Tirassa, Paola ^b   De Bartolo, Paola ^a,c   Caltagirone, Carlo ^a   Petrosini, Laura ^a,c   Angelucci, Francesco ^a  

^a IRCCS FONDAZIONE SANTA LUCIA   (Italy)

^b CNR   (Italy)

^c SAPIENZA UNIVERSITY OF ROME   (Italy)

Author keywords

ChAT; cholinergic neurons; neurotrophins; Saporin

Indexed keywords

NERVE GROWTH FACTOR;

ALZHEIMER DISEASE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN LEVEL; CHOLINERGIC SYSTEM; CONTROLLED STUDY; DEPLETION; FRONTAL CORTEX; HIPPOCAMPUS; HUMAN; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; RAT;

EID: 79960158727     PISSN: 13872877     EISSN: 18758908     Source Type: Journal    
DOI: 10.3233/JAD-2011-110047     Document Type: Article

References (32)

1. Bartus RT, Dean RL, Beer B, Lippa AS (1982) The choliner-gic hypothesis of geriatric memory disfunction. Science 217, 408-414.
2. Bartus RT, Dean RL, Pontecorvo MJ, Flicker C (1985) The cholinergic hypothesis: an historical overview, current perspective, and future directions. Ann N Y Acad Sci 444, 332-358. (Pubitemid 15237840)
3. Salehi A, Delcroix JD, Swaab DF (2004) Alzheimer's disease and NGF signaling. J Neural Transm 111, 323-345. (Pubitemid 38316609)
4. Counts SE, Mufson EJ (2005) The role of nerve growth factor receptors in cholinergic basal forebrain degeneration in prodromal Alzheimer disease. J Neuropathol Exp Neurol 64, 263-272. (Pubitemid 40489553)
5. Niewiadomska G, Mietelska-Porowska A, Mazurkiewicz M (in press) The cholinergic system, nerve growth factor and the cytoskeleton. Behav Brain Res.
6. Roßner S, Wörtwein G, Zexong G, Yu J, Schliebs R, Bigl V, Perez-Polo JR (1997) Cholinergic control of Nerve Growth Factor in adult rats: evidence from cortical cholinergic deaf-ferentation and chronic drug treatment. J Neurochem 69, 947-953. (Pubitemid 27364814)
7. Hock C, Heese K, Hulette C, Rosenberg C, Otten U (2000) Region-specific neurotrophin imbalances in Alzheimer disease. Decreased levels of brain-derived neurotrophic factor and increate levels of nerve growth factor in hippocampus and cortical areas. Arch Neurol 57, 846-851. (Pubitemid 30397187)
8. Cuello AC, Bruno MA, Allard S, Leon W, Iulita MF (2010) Cholinergic involvement in Alzheimer's disease. A link with NGF maturation and degradation. J Mol Neurosci 40, 230-235.
9. Fumagalli F, Molteni R, Calabrese F, Maj PF, Racagni G, Riva MA (2008) Neurotrophic factors in neurodegenerative disorders. Potential for therapy. CNS Drugs 22, 1005-1019.
10. Hellweg R, Gericke CA, Jendroska K, Hartung H-D, Cervós-Navarro J (1998) NGF content in the cerebral cortex of non-demented patients with amyloid-plaques and in symptomatic Alzheimer's disease. Int J Devl Neuroscience 16, 787-794. (Pubitemid 29151766)
11. Schaub RT, Anders D, Golz G, Göhringer K, Hellweg R (2002) Serum nerve growth factor concentration and its role in the preclinical stage of dementia. Am J Psychiatry 159, 1227-1229. (Pubitemid 34743266)
12. Siegel GJ, Chauhan NB (2000) Neurotrophic factors in Alzheimer's and Parkinson's disease brain. Brain Res Brain Res Rev 33, 199-227.
13. Hörtnagl H, Hellweg R (1997) Insights into the role of the cholinergic component of the septohippocampal pathway: what have we learned from experimental lesion studies? Brain Res Bull 43, 245-255. (Pubitemid 27282116)
14. Shaughnessy LW, Barone S Jr (1997) Damage to the NBM leads to a sustained lesion-induced increase in functional NGF in the cortex. Neuroreport 8, 2767-2774. (Pubitemid 27373527)
15. Hellweg R, Humpel C, Löwe A, Hörtnagl H (1997) Moderate lesion of the rat cholinergic septohippocampal pathway increaseses hippocampal nerve growth factor synthesis: evidence for long-term compensatory changes? Brain Res Mol Brain Res 45, 177-181. (Pubitemid 27182243)
16. Gu Z, Yu J, Perez-Polo RP (1998) Responses in the aged rat brain after total immunolesion. J Neurosci Res 54, 7-16. ̀
17. Gericke CA, Lang UE, Steckler T, Schiiulze G, Bajbouj M, Hellweg R(2003) Nerve growth factor responsetoexcitotoxic lesion of the cholinergic basal forebrain is slightly impaired in aged rat. J Neural Transm 110, 627-639. (Pubitemid 36683516)
18. Hellweg R, Lohmann P, Huber R, Kühl A, Riepe MW (2006) Spatial navigation in complex and radial mazes in APP23 animals and neurotrophin signaling as a biological marker of early impairment. Learn Mem 13, 63-71. (Pubitemid 43204397)
19. Schulte-Herbrüggen O, Eckart S, Deicke U, Kühl A, Otten U, Danker-Hopfe H, Abramowski D, Staufenbiel M, Hellweg R (2008) Age-dependent time course of cerebral brain-derived neurotrophic factor, nerve growth factor, and neurotrophin-3 in APP23 transgenic mice. J Neurosci Res 86, 2774-2783.
20. Ziegenhorn AA, Schulte-Herbrüggen O, Danker-Hopfe H, Malbranc M, Hartung HD, Anders D, Lang UE, Steinhagen-Thiessen E, Schaub RT, Hellweg R (2007) Serum neu-rotrophins - A study on the time course and influencing factors in a large old age sample. Neurobiol Aging 28, 1436-1445. (Pubitemid 47090171)
21. Paxinos G, Watson C (1998) The Rat Brain in Stereotaxic Coordinates, Academic Press, San Diego.
22. Glowinski J, Iversen LL (1966) Regional studies of catechol-aminesin the rat brain. I. The disposition of [3H]norepineph- rine, [3H]dopamine and [3 H]dopa in various regions of the brain. J Neurochem 13, 655-669.
23. Fonnum F (1969) Radiochemical micro assays for the determination of choline acetyltransferase and acetylcholine-sterase activities. Biochem J 115, 465-472.
24. Angelucci F, De Bartolo P, Gelfo F, Foti F, Cutuli D, Bossù P, Caltagirone C, Petrosini L (2009) Increased concentrations of nerve growth factor and brain-derived neurotrophic factor in the rat cerebellum after exposure to environmental enrichment. Cerebellum 8, 499-506.
25. Wiley RG, Oeltmann TN, Lappi DA (1991) Immunolesion-ing: selective destruction of neurons using immunotoxin to rat NGF receptor. Brain Res 562, 149-153.
26. Book AA, Wiley RG, Schweitzer JB (1992) Specificity of 192 Ig G-saporin for NGF receptor-positive cholinergic basal forebrain neurons in the rat. Brain Res 590, 350-355.
27. Heckers S, Ohtake T, Wiley RG, Lappi DA, Geula C, Mesu-lam M(1994) Complete and selective cholinergic denervation of rat neocortex and hippocampus but not amygdale by an immunotoxin against the p75 NGF receptor. J Neurosci 14, 1271-1289. (Pubitemid 24081922)
28. Fahnestock M, Michalski B, Xu B, Coughlin MD (2001) The precursor pro-nerve growth factor is the predominant form of nerve growth factor in brain and is increased in Alzheimer's disease. Mol Cell Neurosci 18, 210-220. (Pubitemid 32846529)
29. Nockher WA, Renz H (2005) Neurotrophins in clinical diagnostics: pathophysiology and laboratory investigation. Clin Chim Acta 352, 49-74. (Pubitemid 40093857)
30. Murase K, Nabeshima T, Robitaille Y, Quirion R, Ogawa M, Hayashi K (1993) NGF level of is not decreased in the serum, brain-spinal fluid, hippocampus, or parietal cortex of individuals with Alzheimer's disease.Biochem Biophys Res Commun 193, 198-203. (Pubitemid 23199932)
31. Hellweg R, von Richthofen S, Anders D, Baethge Ch, Röpke St, Hartung H-D, Gericke Ch A (1998) The time course of nerve growth factor content in different neuropsychiatric diseases - a unifying hypothesis. J Neural Transm 105, 871-903. (Pubitemid 28539835)
32. Levi-Montalcini R, Skaper SD, Dal Toso R, Petrelli L, Leon A (1996) Nerve growth factor: from neurotrophin to neurokine. Trends Neurosci 19, 514-520. (Pubitemid 26359871)