Neurobehavioral side effects of corticosteroids during active treatment for acute lymphoblastic leukemia in children are age-dependent: Report from Dana-Farber Cancer Institute ALL Consortium Protocol 00-01

Pediatric Blood and Cancer

Volumn 57, Issue 3, 2011, Pages 492-498

  Mrakotsky, Christine M ^a,b   Silverman, Lewis B ^a,b,c   Dahlberg, Suzanne E ^c   Alyman, M Cheryl A ^d   Sands, Stephen A ^e   Queally, Jennifer T ^a,b   Miller, Tamara P ^f   Cranston, Amy ^d   Neuberg, Donna S ^c   Sallan, Stephen E ^a,b,c   Waber, Deborah P ^a,b  

^a BOSTON CHILDREN S HOSPITAL   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

^c DANA FARBER CANCER INSTITUTE   (United States)

^d MCMASTER UNIVERSITY MEDICAL CENTRE   (Canada)

^e Columbia College of Physicians and Surgeons ^*  (United States)

^f CHILDREN S HOSPITAL OF PHILADELPHIA   (United States)

Author keywords

ALL; Behavior; Chemotherapy neurotoxicities; Corticosteroids; Pediatric hematology oncology

Indexed keywords

DEXAMETHASONE; MERCAPTOPURINE; METHOTREXATE; PREDNISONE; VINCRISTINE;

ACUTE LYMPHOBLASTIC LEUKEMIA; ADOLESCENT; AGGRESSIVENESS; ANXIETY; ARTICLE; ATTENTION DISTURBANCE; BEHAVIOR CHANGE; BEHAVIOR DISORDER; CANCER CENTER; CANCER CHEMOTHERAPY; CANCER PATIENT; CHILD; COGNITION; CONTROLLED STUDY; DEPRESSION; EMOTION; EMOTIONAL DISORDER; EVALUATION; FEMALE; HUMAN; MAJOR CLINICAL STUDY; MALE; MEMORY DISORDER; MOOD; NEUROLOGIC DISEASE; PRESCHOOL CHILD; PRIORITY JOURNAL; RATING SCALE; SCHOOL CHILD; SIDE EFFECT; SINGLE DRUG DOSE; SLEEP DISORDER;

ADOLESCENT; ADRENAL CORTEX HORMONES; ADULT; AGE FACTORS; BEHAVIOR; CHILD; CHILD, PRESCHOOL; DATA COLLECTION; DEXAMETHASONE; FAMILY HEALTH; HUMANS; PARENTS; PRECURSOR CELL LYMPHOBLASTIC LEUKEMIA-LYMPHOMA; PREDNISONE; TIME FACTORS;

EID: 79960153646     PISSN: 15455009     EISSN: 15455017     Source Type: Journal    
DOI: 10.1002/pbc.23060     Document Type: Article

References (26)

1. Packan DR, Sapolsky RM. Glucocorticoid endangerment of the hippocampus: Tissue, steroid and receptor specificity. Neuroendocrinology 1990; 51: 613-618.
2. Sapolsky RM. The possibility of neurotoxicity in the hippocampus in major depression: A primer on neuron death. Biol Psychiatry 2000; 48: 755-765.
3. Conrad CD, McLaughlin KJ, Harman JS, et al. Chronic glucocorticoids increase hippocampal vulnerability to neurotoxicity under conditions that produce CA3 dendritic retraction but fail to impair spatial recognition memory. J Neurosci 2007; 27: 8278-8285.
4. Harris JC, Carel CA, Rosenberg LA, et al. Intermittent high dose corticosteroid treatment in childhood cancer: Behavioral and emotional consequences. J Am Acad Child Psychiatry 1986; 25: 120-124.
5. Bender BG, Lerner JA, Poland JE. Association between corticosteroids and psychologic change in hospitalized asthmatic children. Ann Allergy 1991; 66: 414-419.
6. Drigan R, Spirito A, Gelber RD. Behavioral side effects of corticosteroids in children with acute lymphoblastic leukemia. Med Pediatr Oncol 1992; 20: 13-21.
7. Soliday E, Grey S, Lande MB. Behavioral effects of corticosteroids in steroid-sensitive nephrotic syndrome. Pediatrics 1999; 104: e51.
8. Klein-Gitelman MS, Pachman LM. Intravenous corticosteroids: Adverse reactions are more variable than expected in children. J Rheumatol 1998; 25: 1995-2002.
9. Kayani S, Shannon DC. Adverse behavioral effects of treatment for acute exacerbation of asthma in children: A comparison of two doses of oral steroids. Chest 2002; 122: 624-628.
10. Escher JC, European Collaborative Research Group on Budesonide in Paediatric IBD. Budesonide versus prednisolone for the treatment of active Crohn's disease in children: A randomized, double-blind, controlled, multicentre trial. Eur J Gastroenterol Hepatol 2004; 16: 47-54.
11. Copeland DR, Moore BD, Francis DJ, et al. Neuropsychologic effects of chemotherapy on children with cancer: A longitudinal study. J Clin Oncol 1996; 14: 2826-2835.
12. von der Weid N, Mosimann I, Hirt A, et al. Intellectual outcome in children and adolescents with acute lymphoblastic leukaemia treated with chemotherapy alone: Age- and sex-related differences. Eur J Cancer 2003; 39: 359-365.
13. Lewis LD, Cochrane GM. Psychosis in a child inhaling budesonide. Lancet 1983; 2: 634.
14. Connett G, Lenny W. Inhaled budesonide and behavioural disturbances. Lancet 1991; 338: 634-635.
15. Hochhauser CJ, Lewis M, Kamen BA, et al. Steroid-induced alterations of mood and behavior in children during treatment for acute lymphoblastic leukemia. Support Care Cancer 2005; 13: 967-974.
16. Silverman LB, Gelber RD, Dalton VK, et al. Improved outcome for children with acute lymphoblastic leukemia: Results of Dana-Farber Consortium Protocol 91-01. Blood 2001; 97: 1211-1218.
17. Bostrom BC, Sensel MR, Sather HN, et al. Dexamethasone versus prednisone and daily oral versus weekly intravenous mercaptopurine for patients with standard-risk acute lymphoblastic leukemia: A report from the Children's Cancer Group. Blood 2003; 101: 3809-3817.
18. Mitchell CD, Richards SM, Kinsey SE, et al. Benefit of dexamethasone compared with prednisolone for childhood acute lymphoblastic leukaemia: Results of the UK Medical Research Council ALL97 randomized trial. Br J Haematol 2005; 129: 734-745.
19. Eiser C, Davies H, Jenney M, et al. HRQOL implications of treatment with dexamethasone for children with acute lymphoblastic leukemia (ALL). Pediatr Blood Cancer 2006; 46: 35-39.
20. Vrooman LM, Neuberg DS, Stevenson KE, et al. Dexamethasone and individualized asparaginase dosing are each associated with superior event-free survival in childhood acute lymphoblastic leukemia: Results from DFCI-ALL Consortium Protocol 00-01. Blood 2009; (ASH Annual Meeting Abstracts), 114: 321.
21. Achenbach TA, Rescorla L. Child behavior checklist for ages 1 5-5. Burlington, VT: ASEBA, University of Vermont; 2000.
22. Gioia GA, Isquith PK, Guy SC, et al. Behavior rating inventory of executive function (BRIEF™). Odessa, FL: Psychological Assessment Resources, Inc.; 2000.
23. Achenbach TA. Child behavior checklist for ages 6-18. Burlington, VT: ASEBA, University of Vermont; 2000.
24. Gioia GA, Espy KA, Isquith PK. Behavior rating inventory of executive function-preschool version (BRIEF-P™). Odessa, FL: Psychological Assessment Resources, Inc.; 2003.
25. Mrakotsky C, Silverman L, Levy D, et al. Neurobehavioral side effects of steroid treatment in children with leukemia. J Int Neuropsychol Soc 2004; 10: 58s.
26. Kadan-Lottick NS, Brouwers P, Breiger D, et al. A comparison of neurocognitive functioning in children previously randomized to dexamethasone or prednisone in the treatment of childhood acute lymphoblastic leukemia. Blood 2009; 114: 1746-1752.