Interleukin-2 gene expression in different phases of episodic cluster headache - a pilot study

Acta Neurologica Scandinavica

Volumn 124, Issue 2, 2011, Pages 130-134

  Steinberg, A ^a   Sjostrand C ^a   Sominanda, A ^a   Fogdell Hahn, A ^a   Nilsson Remahl, A I M ^a  

^a KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

Cluster headache; Gene expression; IL 2; Inflammation; RT PCR

Indexed keywords

BIOLOGICAL MARKER; COMPLEMENTARY DNA; CYTOKINE; GLYCERALDEHYDE 3 PHOSPHATE DEHYDROGENASE; INTERLEUKIN 2;

ADOLESCENT; ADULT; ARTICLE; BLOOD ANALYSIS; CHILD; CLINICAL ARTICLE; CONTROLLED STUDY; EPISODIC CLUSTER HEADACHE; FEMALE; GENE EXPRESSION; HUMAN; IMMUNE SYSTEM; MALE; PATHOPHYSIOLOGY; PILOT STUDY; PRESCHOOL CHILD; QUANTITATIVE ANALYSIS; REAL TIME POLYMERASE CHAIN REACTION; REMISSION; SCHOOL CHILD; VENOUS BLOOD;

ADULT; ANALYSIS OF VARIANCE; CASE-CONTROL STUDIES; CLUSTER HEADACHE; FEMALE; GENE EXPRESSION; HUMANS; INTERLEUKIN-2; MALE; MIDDLE AGED; PILOT PROJECTS; STATISTICS, NONPARAMETRIC;

EID: 79960143815     PISSN: 00016314     EISSN: 16000404     Source Type: Journal    
DOI: 10.1111/j.1600-0404.2010.01434.x     Document Type: Article

References (21)

1. Headache Classification Subcommittee of the International Headache Society. International classification of headache disorders, 2nd Edn. Cephalalgia 2004;24 (Suppl. 1):13.
2. Ekbom K. Cluster headache: an overview. Ital J Neurol Sci 1999;20:S1-3.
3. Ekbom K, Greitz T. Carotid angiography in cluster headache. Acta Radiol Diagn (Stockh) 1970;10:177-86.
4. Moskowitz MA. Cluster headache: evidence for a pathophysiologic focus in the superior pericarotid cavernous sinus plexus. Headache 1988;28:584-6.
5. Hannerz J, Hellstrom G, Klum T, Wahlgren NG. Cluster headache and "dynamite headache": blood flow velocities in the middle cerebral artery. Cephalalgia 1990;10:31-8.
6. Goadsby PJ, Edvinsson L. Human in vivo evidence for trigeminovascular activation in cluster headache. Neuropeptide changes and effects of acute attacks therapies. Brain 1994;117:427-34.
7. May A, Bahra A, Buchel C, Frackowiak RS, Goadsby PJ. Hypothalamic activation in cluster headache attacks. Lancet 1998;352:275-8.
8. Leone M, Franzini A, Bussone G. Stereotactic stimulation of posterior hypothalamic gray matter in a patient with intractable cluster headache. N Engl J Med 2001;345:1428-9.
9. Hannerz J. Orbital phlebography and signs of inflammation in episodic and chronic cluster headache. Headache 1991;31:540-2.
10. Hardebo JE. How cluster headache is explained as an intracavernous inflammatory process lesioning sympathetic fibers. Headache 1994;34:125-31.
11. Nilsson Remahl AIM, Waldenlind E, Bratt J, Ekbom K. Cluster headache is not associated with signs of a systemic inflammation. Headache 2000;40:276-81.
12. Sjöstrand C, Duvefelt K, Steinberg A, Nilsson Remahl AIM, Waldenlind E, Hillert J. Gene expression profiling in cluster headache: a pilot microarray study. Headache 2006;46:1518-34.
13. Martelletti P, Granata M, Giacovazzo M. Serum interleukin-1 beta is increased in cluster headache. Cephalalgia 1993;13:343-5; discussion 307-308.
14. Empl M, Förderreuther S, Schwarz M, Müller N, Straube A. Soluble interleukin-2 receptors increase during the active periods in cluster headache. Headache 2003;43:63-8.
15. Immunobiology; The immune system in health and disease, 4th edn. Janeway CA, Travers P, Walport M, Capra JD, eds. T-cell mediated immunity. London: Elsevier Science Ltd/Garland Publishing, 1999; 263-84.
16. Gaffen SL, Liu KD. Overview of interleukin-2 function, production and clinical applications. Cytokine 2004;28:109-23.
17. -ΔΔCT method. Methods 2001;25:402-8.
18. Guidi L, Tricerri A, Vangeli M et al. Neuropeptide Y plasma levels and immunological changes during academic stress. Neuropsychobiology 1999;40:188-95.
19. Naliboff BD, Benton D, Solomon GF et al. Immunological changes in young and old adults during brief laboratory stress. Psychosom Med 1991;53:121-32.
20. Abbas A, Lichtman AH, Pillai S. Cellular and molecular immunology, 6th edn. Philadelphia: Elsevier, 2007.
21. Haack M, Pollmächer T, Mullington JM. Diurnal and sleep-wake dependent variations of soluble TNF- and IL-2 receptors in healthy volunteers. Brain Behav Immun 2004;18:361-7.