Antibody recognition of a human chorionic gonadotropin epitope (hCGβ 66-80) depends on local structure retained in the free peptide

Journal of Biological Chemistry

Volumn 286, Issue 28, 2011, Pages 25016-25026

  Gregor, Craig R ^a   Cerasoli, Eleonora ^b   Schouten, James ^c   Ravi, Jascindra ^b   Slootstra, Jerry ^d   Horgan, Adrian ^b   Martyna, Glenn J ^e   Ryadnov, Maxim G ^a,b   Davis, Paul ^c   Crain, Jason ^a,b  

^a UNIVERSITY OF EDINBURGH   (United Kingdom)

^b NATIONAL PHYSICAL LABORATORY   (United Kingdom)

^c Mologic Ltd   (United Kingdom)

^d Pepscan Presto BV   (Netherlands)

^e IBM T J WATSON RESEARCH CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID RESIDUES; ANTIBODY RECOGNITION; ATOMISTIC COMPUTER SIMULATION; BINDING AFFINITIES; COMPETITIVE IMMUNOASSAY; HUMAN CHORIONIC GONADOTROPINS; HYDROGEN BONDING MOTIFS; LOCAL STRUCTURE; OPTICAL SPECTROSCOPIC; STRUCTURAL DIFFERENCES;

AMINO ACIDS; BINDING ENERGY; COMPUTER SIMULATION; HYDROGEN BONDS; MONOCLONAL ANTIBODIES; PEPTIDES;

ANTIGENS;

CHORIONIC GONADOTROPIN BETA SUBUNIT; EPITOPE; LUTEINIZING HORMONE BETA SUBUNIT; MONOCLONAL ANTIBODY;

AMINO ACID SEQUENCE; ANTIBODY AFFINITY; ANTIBODY SPECIFICITY; ANTIGEN BINDING; ARTICLE; BINDING AFFINITY; COMPUTER SIMULATION; CONTROLLED STUDY; HYDROGEN BOND; IMMUNOASSAY; PRIORITY JOURNAL; PROTEIN MOTIF; PROTEIN STRUCTURE; SPECTROSCOPY;

ANIMALS; ANTIBODIES, MONOCLONAL, MURINE-DERIVED; CHORIONIC GONADOTROPIN, BETA SUBUNIT, HUMAN; COMPUTER SIMULATION; EPITOPES; FEMALE; HUMANS; IMMUNOASSAY; MICE; PEPTIDES; PREGNANCY; PROTEIN STRUCTURE, SECONDARY; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 79960127037     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.246637     Document Type: Article

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