Zonal rate model for stacked membrane chromatography. I: Characterizing solute dispersion under flow-through conditions

Journal of Chromatography A

Volumn 1218, Issue 31, 2011, Pages 5071-5078

  Francis, Patrick ^a   Von Lieres, Eric ^b   Haynes, Charles A ^a  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^b FORSCHUNGSZENTRUM JÜLICH   (Germany)

Author keywords

Chromatography; Dispersion; Hydrodynamics; Ion exchange chromatography; Mass transfer; Membrane chromatography; Protein purification

Indexed keywords

ANION EXCHANGE MEMBRANE; BAND-BROADENING; BREAK THROUGH CURVE; COLUMN LENGTHS; CONVENTIONAL MODELS; DISPERSION OF SOLUTES; DOMINANT CONTRIBUTIONS; FEED FLOW RATE; FLOWTHROUGH; HEIGHT RATIO; HOLD UP; ION-EXCHANGE CHROMATOGRAPHY; MEMBRANE CHROMATOGRAPHY; MEMBRANE STACKS; MODEL PROTEINS; NON-IDEALITIES; NON-UNIFORM FLOWS; OVALBUMINS; PLUG FLOW REACTOR; PROTEIN PURIFICATION; RATE MODELS; RESIDENCE TIME; RESIDENCE TIME DISTRIBUTIONS; SOLUTE DISPERSIONS; STIRRED TANK REACTORS; VOLUME MODELS;

DISPERSIONS; FLOW RATE; INLET FLOW; MEMBRANES; PROTEINS;

COLUMN CHROMATOGRAPHY;

OVALBUMIN;

ACCURACY; ANION EXCHANGE CHROMATOGRAPHY; ANION EXCHANGE MEMBRANE CHROMATOGRAPHY; ARTICLE; CHROMATOGRAPHY; CONTROLLED STUDY; DISPERSION; FLOW RATE; HYDRODYNAMICS; PHYSICAL MODEL; PLUG FLOW REACTOR; PRIORITY JOURNAL; PROTEIN PURIFICATION; SOLUTE; STACKED MEMBRANE CHROMATOGRAPHY; STIRRED REACTOR; ZONAL RATE MODEL;

ADSORPTION; CHROMATOGRAPHY, ION EXCHANGE; MEMBRANES, ARTIFICIAL; MODELS, CHEMICAL; OVALBUMIN;

EID: 79960112959     PISSN: 00219673     EISSN: 18733778     Source Type: Journal    
DOI: 10.1016/j.chroma.2011.05.017     Document Type: Article

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